Navigation Links
Researchers discover how underground rodent wards off cancer
Date:11/5/2012

Biologists at the University of Rochester have determined how blind mole rats fight off cancerand the mechanism differs from what they discovered three years ago in another long-lived and cancer-resistant mole rat species, the naked mole rat.

The team of researchers, led by Professor Vera Gorbunova and Assistant Professor Andrei Seluanov, found that abnormally growing cells in blind mole rats secrete the interferon beta protein, which causes those cells to rapidly die. Seluanov and Gorbunova hope the discovery will eventually help lead to new cancer therapies in humans. Their findings are being published this week in the Proceedings of the National Academy of Sciences.

Blind mole rats and naked mole ratsboth subterranean rodents with long life spansare the only mammals never known to develop cancer. Three years ago, Seluanov and Gorbunova determined the anti-cancer mechanism in the naked mole rat. Their research found that a specific genep16makes the cancerous cells in naked mole rats hypersensitive to overcrowding, and stops them from proliferating when too many crowd together.

"We expected blind mole rats to have a similar mechanism for stopping the spread of cancerous cells," said Seluanov. "Instead, we discovered they've evolved their own mechanism."

Gorbunova and Seluanov made their discovery by isolating cells from blind mole rats and forcing them to proliferate in culture beyond what occurs in the animal. After dividing approximately 15-20 times, all of the cells in the culture dish died rapidly. The researchers determined that the rapid death occurred because the cells recognized their pre-cancerous state and began secreting a suicidal protein, called interferon beta. The precancerous cells died by a mechanism which kills both abnormal cells and their neighbors, resulting in a "clean sweep."

"Not only were the cancerous cells killed off, but so were the adjacent cells, which may also be prone to tumor
'/>"/>

Contact: Peter Iglinski
peter.iglinski@rochester.edu
585-273-4726
University of Rochester
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Forum to bring together leading-edge ophthalmic researchers and investors
2. George Mason University researchers target breast cancer in 3 trials
3. IU researchers report first effective treatment of tumors arising from common genetic disease NF1
4. OHSU researchers discover potential way to repair brain damage in multiple sclerosis
5. Penn researchers find error reporting improves perceptions of safety and may reduce incidents
6. Common Antidepressants Too Risky During Pregnancy, Researchers Say
7. Mechanism found for destruction of key allergy-inducing complexes, Stanford researchers say
8. Feinstein Institute researchers discover that bean used in Chinese food could protect against sepsis
9. Mayo Clinic researchers develop new tools to better treat ADHD patients in early stages
10. Moffitt Researchers find genetic predictors of fatigue for some prostate cancer patients
11. Penn Medicine researchers map strategy for choosing wisely on low-value health care services
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers discover how underground rodent wards off cancer
(Date:9/15/2014)... DALLAS, TX September 12, 2014 - An estimated ... disorder (PTSD) at some point during their lifetime. Brought ... PTSD is the result of altered chemistry and physiology ... a normal brain versus one altered by PTSD is ... from the Center for BrainHealth at The University of ...
(Date:9/15/2014)... 2014 The White House has recently ... offenders in jail and prison and toward helping them ... as a positive change. , The nation is currently ... abuse. According to an article from The Washington ... a shift away from using the criminal justice system ...
(Date:9/15/2014)... 2014 This year, Avenidas Village ... 2007. To mark the special occasion, Avenidas Village would ... village and helping it to get started seven years ... fun community for seniors. Members of Avenidas Village maintain ... in their own homes. They are able to have ...
(Date:9/15/2014)... Maureen Salamon HealthDay ... -- Pediatricians prescribe antibiotics about twice as often as ... infections, a new study indicates. More than 11 ... teens may be unnecessary, according to researchers from University ... use not only fails to eradicate children,s viral illnesses, ...
(Date:9/15/2014)... By Amy Norton ... -- A relatively small number of medications are responsible for ... ingestion, a U.S. government study finds. Each year between ... years were hospitalized after getting a hold of family members, ... Prevention. "Three-quarters of those children were just 1 ...
Breaking Medicine News(10 mins):Health News:EEG study findings reveal how fear is processed in the brain 2Health News:White House Shifts Policy on Drugs 2Health News:Avenidas Village Celebrates Anniversary 2Health News:Kids Prescribed Antibiotics Twice as Often as Needed, Study Finds 2Health News:Kids Prescribed Antibiotics Twice as Often as Needed, Study Finds 3Health News:Small Number of Drugs Behind Kids' Accidental Poisonings: CDC 2Health News:Small Number of Drugs Behind Kids' Accidental Poisonings: CDC 3
... and Highlights Potential Factors that Affect Health Outcomes, in ... N.J., Jan. 14 Results from the LATINO study, ... the hepatitis C virus (HCV), were published today in ... This Roche study demonstrated that HCV can be successfully ...
... considerable reduction in infection rates, , , WEDNESDAY, Jan. 14 ... life-threatening infection, have declined substantially since a new vaccine ... The declines have been seen not only in children ... herd immunity effect, the researchers noted. To assess the ...
... 14 Home Care Assistance has,partnered with a ... consistently high rankings in sponsored and organic searches ... that delivers thousands of,leads critical to franchisee business ... commitment to provide solutions that offer immediate,business results ...
... of Inauguration Day, Berry,Chill is offering free Berry Obama ... , The Berry Obama is ... with blueberries, blue candy-covered almonds, and blue,sprinkles to reflect ... the special combination will be topped with fresh pomegranate,coconut ...
... 14 A surge of arctic air forecast to ... chills that could lead to serious health problems, the ... to range from the single digits to minus 10 ... to 30 below zero. "Taking preventive action can help ...
... Benzoyl Peroxide Wash to Utilize MICROSPONGE(R) Delivery SystemCARLSBAD, ... the launch of NeoBenz Micro Wash, ... with the MICROSPONGE (R) delivery system, for ... NeoBenz Micro Wash contains 7% benzoyl ...
Cached Medicine News:Health News:PEGASYS(R) Proven Effective as Hepatitis C Treatment for Latino Patients, According to Article in The New England Journal of Medicine 2Health News:PEGASYS(R) Proven Effective as Hepatitis C Treatment for Latino Patients, According to Article in The New England Journal of Medicine 3Health News:PEGASYS(R) Proven Effective as Hepatitis C Treatment for Latino Patients, According to Article in The New England Journal of Medicine 4Health News:PEGASYS(R) Proven Effective as Hepatitis C Treatment for Latino Patients, According to Article in The New England Journal of Medicine 5Health News:PEGASYS(R) Proven Effective as Hepatitis C Treatment for Latino Patients, According to Article in The New England Journal of Medicine 6Health News:PEGASYS(R) Proven Effective as Hepatitis C Treatment for Latino Patients, According to Article in The New England Journal of Medicine 7Health News:PEGASYS(R) Proven Effective as Hepatitis C Treatment for Latino Patients, According to Article in The New England Journal of Medicine 8Health News:PEGASYS(R) Proven Effective as Hepatitis C Treatment for Latino Patients, According to Article in The New England Journal of Medicine 9Health News:Meningitis Vaccine Seems to Work Like a Charm 2Health News:Meningitis Vaccine Seems to Work Like a Charm 3Health News:Home Care Franchise Forms Strategic Partnership with Google(TM) 2Health News:Inauguration Day Deal: Get a Free Berry Obama Chilled Yogurt at Berry Chill 2Health News:Department of Health Urges Pennsylvanians to Prepare For Dangerously Cold Weather 2Health News:SkinMedica(R) Launches NeoBenz(R) Micro Wash for Acne 2Health News:SkinMedica(R) Launches NeoBenz(R) Micro Wash for Acne 3
(Date:9/15/2014)... , Sept. 15, 2014  Catalist-listed QT Vascular ... Group"), a developer and manufacturer of minimally invasive medical ... to announce that the Group has enrolled the first ... Germany . Multiple patients have already been enrolled ... at Auckland City Hospital, in Auckland, New ...
(Date:9/15/2014)... PDL BioPharma, Inc. (PDL) (NASDAQ: ... September 12, 2014, regular quarterly dividend payment of $0.15 per ... of September 5, 2014, the record date. ... portfolio of patents and royalty assets, consisting primarily of ... agreements with various biotechnology and pharmaceutical companies. PDL pioneered ...
(Date:9/15/2014)... Sept. 15, 2014 Research and Markets ... Drug Transfer Systems to 2020" report to their ... hazardous to humans has been receiving increasing amounts of ... substances become more clearly understood. For caregivers and their ... of attempts to mitigate exposure to cytotoxic drugs is ...
Breaking Medicine Technology:First European Patients Enrolled in QT Vascular's ENDURE Trial 2First European Patients Enrolled in QT Vascular's ENDURE Trial 3First European Patients Enrolled in QT Vascular's ENDURE Trial 4First European Patients Enrolled in QT Vascular's ENDURE Trial 5PDL BioPharma Completes Regular Quarterly Dividend Payment 2Closed Drug Transfer Systems to 2020 2Closed Drug Transfer Systems to 2020 3
... Germany, Sept. 20, 2011 Weight and height, their ... for medical measuring and weighing. Now the company is ... integrating modern medical practices and hospital equipment. The new ... of precise data capture, transmission and interpretation of weight, ...
... – Ingenuity® Systems, a leading provider of ... researchers, today announced the addition of new ... miRecords , plus thousands of additional miRNA-mRNA ... The newly added content supplements existing experimentally ...
Cached Medicine Technology:seca 360 wireless - The New Era of Measuring and Weighing 2Ingenuity Announces New Additional MicroRNA Content to Complement First-of-its-Kind MicroRNA Filtering Capability in IPA 2
... unique system uses prolene as thread-guide reducing ... The hollow Ritleng Probe is inserted into ... thread-guide is fed through it. The probe ... to pull the silicone tubing in place. ...
... For canalicular laceration or imperforate ... and Stainless Steel Probe. Box ... securely swaged into malleable stainless ... by punctum plug: no knots, ...
For Canalicular Stenosis. Non-traumatic tip. Silicone tubing swaged into probe. Note: Tubing securely swaged into malleable stainless steel probes. Medical grade silicone. Box of 3, sterile....
Recommended to insert plug portion of all monocanalicular intubation systems into punctum....
Medicine Products: