Navigation Links
Researchers discover how underground rodent wards off cancer
Date:11/5/2012

Biologists at the University of Rochester have determined how blind mole rats fight off cancerand the mechanism differs from what they discovered three years ago in another long-lived and cancer-resistant mole rat species, the naked mole rat.

The team of researchers, led by Professor Vera Gorbunova and Assistant Professor Andrei Seluanov, found that abnormally growing cells in blind mole rats secrete the interferon beta protein, which causes those cells to rapidly die. Seluanov and Gorbunova hope the discovery will eventually help lead to new cancer therapies in humans. Their findings are being published this week in the Proceedings of the National Academy of Sciences.

Blind mole rats and naked mole ratsboth subterranean rodents with long life spansare the only mammals never known to develop cancer. Three years ago, Seluanov and Gorbunova determined the anti-cancer mechanism in the naked mole rat. Their research found that a specific genep16makes the cancerous cells in naked mole rats hypersensitive to overcrowding, and stops them from proliferating when too many crowd together.

"We expected blind mole rats to have a similar mechanism for stopping the spread of cancerous cells," said Seluanov. "Instead, we discovered they've evolved their own mechanism."

Gorbunova and Seluanov made their discovery by isolating cells from blind mole rats and forcing them to proliferate in culture beyond what occurs in the animal. After dividing approximately 15-20 times, all of the cells in the culture dish died rapidly. The researchers determined that the rapid death occurred because the cells recognized their pre-cancerous state and began secreting a suicidal protein, called interferon beta. The precancerous cells died by a mechanism which kills both abnormal cells and their neighbors, resulting in a "clean sweep."

"Not only were the cancerous cells killed off, but so were the adjacent cells, which may also be prone to tumorous behavior," said Seluanov.

"While people don't use the same cancer-killing mechanism as blind mole rats, we may be able to combat some cancers and prolong life, if we could stimulate the same clean sweep reaction in cancerous human cells," said Gorbunova.

The research team also included Christopher Hine, Xiao Tian, and Julia Ablaeva in Rochester, Andrei Gudkov at Roswell Park Cancer Institute in Buffalo, NY, and Eviatar Nevo at the University of Haifa in Israel.

Gorbunova and Seluanov say they next want to find out exactly what triggers the secretion of interferon beta after cancerous cells begin proliferating in blind mole rats.

Gorbunova believes the anti-cancer mechanism is an adaptation to subterranean life. "Blind mole rats spend their lives in underground burrows protected from predators," said Gorbunova. "Living in this environment, they could perhaps afford to evolve a long lifespan, which includes developing efficient anti-cancer defenses."


'/>"/>

Contact: Peter Iglinski
peter.iglinski@rochester.edu
585-273-4726
University of Rochester
Source:Eurekalert  

Related medicine news :

1. Forum to bring together leading-edge ophthalmic researchers and investors
2. George Mason University researchers target breast cancer in 3 trials
3. IU researchers report first effective treatment of tumors arising from common genetic disease NF1
4. OHSU researchers discover potential way to repair brain damage in multiple sclerosis
5. Penn researchers find error reporting improves perceptions of safety and may reduce incidents
6. Common Antidepressants Too Risky During Pregnancy, Researchers Say
7. Mechanism found for destruction of key allergy-inducing complexes, Stanford researchers say
8. Feinstein Institute researchers discover that bean used in Chinese food could protect against sepsis
9. Mayo Clinic researchers develop new tools to better treat ADHD patients in early stages
10. Moffitt Researchers find genetic predictors of fatigue for some prostate cancer patients
11. Penn Medicine researchers map strategy for choosing wisely on low-value health care services
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers discover how underground rodent wards off cancer
(Date:9/22/2017)... ... September 22, 2017 , ... “Letters From Home”: a moving compilation of ... value to God. “Letters From Home” is the creation of published author, John Allred, ... Cabinet of Jerry Savelle Ministries International, who has traveled and ministered on four continents. ...
(Date:9/21/2017)... ... September 21, 2017 , ... With ProSlideshow Portrait from Pixel Film Studios creating ... can select from up to two layers of subject matter along with fully customizable ... within Final Cut Pro X. , With ProSlideshow Portrait each user are ...
(Date:9/21/2017)... ... 21, 2017 , ... The American Addiction Treatment Association (AATA) ... in the addiction treatment industry entitled: Special Investigations Unit (SIU) – What ... state and federal governments are increasingly scrutinizing the addiction treatment industry for fraudulent ...
(Date:9/21/2017)... Ca (PRWEB) , ... September 21, 2017 , ... Bill ... services to its customers, and give back to the community. For over 37 years, ... the most successful companies serving plumbing in San Diego. They were chosen ...
(Date:9/21/2017)... ... September 21, 2017 , ... Preora Diagnostics Inc. ... screening tests, has received two prestigious recognitions that acknowledge the promise of its ... Preora has been named a Top 100 Finalist for the 16th annual ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, ... tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek , PhD, ...
(Date:9/18/2017)... R.I. , Sept. 18, 2017 /PRNewswire/ ... the fields of bioinformatics and immune engineering, ... a protective avian influenza A (H7N9) vaccine. ... distantly related to seasonal influenza and presents ... rely on prior exposure to be effective. ...
(Date:9/12/2017)...  Consumer reviews on the independent review site Consumer Affairs ... company for hearing aids, ranking it higher than Miracle Ear ... ... For Hearing Aids ... online store that provides high performance, state-of-the-art, German-engineered hearing aids directly ...
Breaking Medicine Technology: