Navigation Links
Researchers discover how underground rodent wards off cancer
Date:11/5/2012

Biologists at the University of Rochester have determined how blind mole rats fight off cancerand the mechanism differs from what they discovered three years ago in another long-lived and cancer-resistant mole rat species, the naked mole rat.

The team of researchers, led by Professor Vera Gorbunova and Assistant Professor Andrei Seluanov, found that abnormally growing cells in blind mole rats secrete the interferon beta protein, which causes those cells to rapidly die. Seluanov and Gorbunova hope the discovery will eventually help lead to new cancer therapies in humans. Their findings are being published this week in the Proceedings of the National Academy of Sciences.

Blind mole rats and naked mole ratsboth subterranean rodents with long life spansare the only mammals never known to develop cancer. Three years ago, Seluanov and Gorbunova determined the anti-cancer mechanism in the naked mole rat. Their research found that a specific genep16makes the cancerous cells in naked mole rats hypersensitive to overcrowding, and stops them from proliferating when too many crowd together.

"We expected blind mole rats to have a similar mechanism for stopping the spread of cancerous cells," said Seluanov. "Instead, we discovered they've evolved their own mechanism."

Gorbunova and Seluanov made their discovery by isolating cells from blind mole rats and forcing them to proliferate in culture beyond what occurs in the animal. After dividing approximately 15-20 times, all of the cells in the culture dish died rapidly. The researchers determined that the rapid death occurred because the cells recognized their pre-cancerous state and began secreting a suicidal protein, called interferon beta. The precancerous cells died by a mechanism which kills both abnormal cells and their neighbors, resulting in a "clean sweep."

"Not only were the cancerous cells killed off, but so were the adjacent cells, which may also be prone to tumorous behavior," said Seluanov.

"While people don't use the same cancer-killing mechanism as blind mole rats, we may be able to combat some cancers and prolong life, if we could stimulate the same clean sweep reaction in cancerous human cells," said Gorbunova.

The research team also included Christopher Hine, Xiao Tian, and Julia Ablaeva in Rochester, Andrei Gudkov at Roswell Park Cancer Institute in Buffalo, NY, and Eviatar Nevo at the University of Haifa in Israel.

Gorbunova and Seluanov say they next want to find out exactly what triggers the secretion of interferon beta after cancerous cells begin proliferating in blind mole rats.

Gorbunova believes the anti-cancer mechanism is an adaptation to subterranean life. "Blind mole rats spend their lives in underground burrows protected from predators," said Gorbunova. "Living in this environment, they could perhaps afford to evolve a long lifespan, which includes developing efficient anti-cancer defenses."


'/>"/>

Contact: Peter Iglinski
peter.iglinski@rochester.edu
585-273-4726
University of Rochester
Source:Eurekalert  

Related medicine news :

1. Forum to bring together leading-edge ophthalmic researchers and investors
2. George Mason University researchers target breast cancer in 3 trials
3. IU researchers report first effective treatment of tumors arising from common genetic disease NF1
4. OHSU researchers discover potential way to repair brain damage in multiple sclerosis
5. Penn researchers find error reporting improves perceptions of safety and may reduce incidents
6. Common Antidepressants Too Risky During Pregnancy, Researchers Say
7. Mechanism found for destruction of key allergy-inducing complexes, Stanford researchers say
8. Feinstein Institute researchers discover that bean used in Chinese food could protect against sepsis
9. Mayo Clinic researchers develop new tools to better treat ADHD patients in early stages
10. Moffitt Researchers find genetic predictors of fatigue for some prostate cancer patients
11. Penn Medicine researchers map strategy for choosing wisely on low-value health care services
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers discover how underground rodent wards off cancer
(Date:2/8/2016)... ... ... Coast Dental has a new way to help parents keep their children's ... Yvonne Dorrian, DMD, is hosting a free seminar on Friday, February 19 from 2 ... 1207 North Peachtree Parkway in Peachtree City. Dr. Dorrian will have healthy snacks, activities, ...
(Date:2/8/2016)... York, NY (PRWEB) , ... February 08, 2016 , ... ... are too much to handle, you are not alone. According to the Center for ... include heart disease, stroke, type 2 diabetes and certain types of cancer, some of ...
(Date:2/8/2016)... San Francisco, CA (PRWEB) , ... February 08, 2016 , ... ... helped raise $792,000 to help combat pancreatic cancer. , Gary D. Radine, who recently ... who also was the American Cancer Society’s 2015 CEO of the Year , ...
(Date:2/8/2016)... ... February 08, 2016 , ... Discover the Rocky Mountain region’s longest ... and 700 companies. Attendees also get to see the most incredible gardens and ... Home Show , at the Colorado Convention Center - 700 14th St. Denver CO, ...
(Date:2/8/2016)... , ... February 08, 2016 , ... Guruji Mahendra Kumar ... 10th and 11th, 2016 in honor of his birthday on February 10th. During ... Mahendra Trivedi is known by over 250,000 people from over 40 different countries ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)...  The University of Michigan Health System in ... part of the development of four new operating rooms, ... the U.S. to start using new top-of-the-line neurosurgical imaging ... of neurosurgery. --> Karin Muraszko , ... The BrightMatter technology from Synaptive Medical – a highly ...
(Date:2/8/2016)... 2016  Aoxing Pharmaceutical Company, Inc. (NYSE MKT: AXN) today ... ended December 31, 2015, the Company achieved revenue of $8,195,839, ... same quarter in fiscal 2015. --> ... fiscal year 2016 was $2,068,635, or $.03 per share, up ... share, in the Q2 of fiscal year 2015. Gross margin ...
(Date:2/8/2016)... , Feb. 8, 2016 ... the addition of the "Label-Free Detection ... Forecasts to 2020" report to their ... announced the addition of the "Label-Free ... Global Forecasts to 2020" report to ...
Breaking Medicine Technology: