Navigation Links
Researchers discover how to shutdown cancer's powerful master protein
Date:3/3/2013

e targeted, some researchers have been testing alternative therapeutic approaches. This study strongly supports the notion of using Bcl6-targeting drugs."

In fact, the findings in this study were inspired from preclinical testing of two Bcl6-targeting agents that Dr. Melnick and his Weill Cornell colleagues have developed to treat DLBCLs. These experimental drugs are RI-BPI, a peptide mimic, and the small molecule agent 79-6.

Dr. Melnick says the discovery that a master regulatory transcription factor can be targeted offers implications beyond just treating DLBCL. Recent studies from Dr. Melnick and others have revealed that Bcl6 plays a key role in the most aggressive forms of acute leukemia, as well as certain solid tumors.

Transcription factors are responsible for either inhibiting or promoting the expression of genes, and master regulatory transcription factors are the equivalent of the CPU of a computer their actions regulate thousands of genes in different kinds of cells. For example, Bcl6 can control the type of immune cell that develops in the bone marrow -- playing many roles in the development of B cells, T cells, macrophages and other cells -- including a primary and essential role in enabling B-cells to generate specific antibodies against pathogens.

"When cells lose control of Bcl6, lymphomas develop in the immune system. Lymphomas are 'addicted' to Bcl6, and therefore Bcl6 inhibitors powerfully and quickly destroy lymphoma cells," Dr. Melnick says.

The big surprise in the current study is that rather than functioning as a single molecular machine, Bcl6 instead seems to function more like a Swiss Army knife, using different tools to control different cell types. This multi-function paradigm could represent a general model for the functioning of other master regulatory transcription factors.

"In this analogy, the Swiss Army knife, or transcription factor, keeps most of its tools folded, opening on
'/>"/>

Contact: Lauren Woods
Law2014@med.cornell.edu
646-317-7401
Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. UGA researchers identify brain pathway triggering impulsive eating
2. Researchers show that lipid nanoparticles are ideal for delivering genes and drugs
3. Researchers at the UH Cancer Center discover protein that may control the spread of cancer
4. Now hear this: Stanford researchers identify forerunners of inner-ear cells that enable hearing
5. Researchers explore PKC role in lung disease
6. Baylor University researchers study barriers, resources to physical activity in Texas towns
7. Researchers identify variations in 4 genes associated with an increased risk of colorectal cancer
8. Researchers identify variations in four genes associated with an increased risk of colorectal cancer
9. NIH-funded researchers begin trial of Shigella vaccine candidates
10. Moffitt researchers say silencing of retinoblastoma gene regulates differentiation of myeloid cells
11. Researchers guardians of trust in biobank research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... at the Institute of Bioengineering and Nanotechnology (IBN), ... Singapore (NCCS) have co-developed the first molecular test ... in kidney cancer patients. This breakthrough was recently ... top urology journal. , According to IBN ... our expertise in molecular diagnostics and cancer research, ...
(Date:8/1/2014)... St. Christopher's Hospital for Children announced that they ... with Ed Begley Jr, airing later this year 2014, ... St. Christopher's Hospital for Children offers a wide range ... 21 years of age. With over 220 pediatric specialists, ... autism and childhood obesity. , “St. Christopher’s is ...
(Date:8/1/2014)... Jordan, Utah (PRWEB) August 01, 2014 ... company MonaVie, who completes its 500th week of paying ... since the company was founded in January 2005 total ... countries throughout the world. The company pays commissions in ... HUF, ILS, JPY, MYR, MXN, NZD, PLN, USD, SGD, ...
(Date:8/1/2014)... BellasDress has recently showcased its beautifully ... season’s gorgeous styles. The company’s lot of hot styles, ... outfits, one shoulder chiffon outfits and high low outfits. ... elegant purple prom dresses. As one of the most ... product quality. Thus, all its items are of superb ...
(Date:8/1/2014)... CentraComm, a leading managed IT security ... the Pure Storage® Authorized Reseller program. , ... experience designed to meet the rigorous resiliency, scalability, ... diverse markets, and for a variety of high ... years. , The Pure Storage FlashArray was ...
Breaking Medicine News(10 mins):Health News:Taking the guesswork out of cancer therapy 2Health News:Taking the guesswork out of cancer therapy 3Health News:Innovations with Ed Begley, Jr. to Feature St. Christopher's Hospital for Children in Upcoming Episode 2Health News:Innovations with Ed Begley, Jr. to Feature St. Christopher's Hospital for Children in Upcoming Episode 3Health News:MonaVie Records 500th Commission Week, Having Paid Out More Than $1.4B in Distributor Commissions 2Health News:BellasDress Creates Must-have Purple Prom Dresses for Prom Attendees 2Health News:CentraComm Accepts Pure Storage Authorized Reseller Partner Invitation 2Health News:CentraComm Accepts Pure Storage Authorized Reseller Partner Invitation 3
... , ... Products at E3 Expo To Show Off Consumer Market Appeal and Wellness Benefits for Gamers ... Los Angeles, CA (Vocus) ... innovative musical instruments and music software to enable people of all ages and skill levels ...
... ... of your control environment, SAS 70 reports have become a credible marketing tool to ... ... is a leading provider that specializes solely in SAS 70 readiness reviews, SAS 70 Type ...
... promising. Sorafenib is used for advanced liver and kidney ... stem cells in pancreatic cancer. The team led by ... Molecular Oncosurgery, a group of the Department of Surgery ... W. Bchler) in cooperation with the German Cancer Research ...
... with the right information, physicians can play a stronger ... drugs proven to prevent asthma attacks, according to researchers ... finds patients are more likely to routinely take inhaled ... watch over their medication use and reviewed detailed electronic ...
... ... same-day healthcare appointments online. , ... Chicago, IL (PRWEB) June 15, 2010 -- ZocDoc, the website to ... metropolitan area. The company’s move was chosen by thousands of users, who were asked ...
... ... process should not be undertaken without legal representation, urges American Residential Law Group. ... Fort Lauderdale, FL ... foreclosure not to go through the mortgage modification process without viable legal help on ...
Cached Medicine News:Health News:Beamz Announces Partnership with Dynaflex International at E3 Expo 2Health News:Beamz Announces Partnership with Dynaflex International at E3 Expo 3Health News:Beamz Announces Partnership with Dynaflex International at E3 Expo 4Health News:Can a SAS 70 Audit Create a Competitive Advantage for Your Business? 2Health News:Can a SAS 70 Audit Create a Competitive Advantage for Your Business? 3Health News:Can a SAS 70 Audit Create a Competitive Advantage for Your Business? 4Health News:New combination effective against pancreatic cancer 2Health News:Study: Getting patients to take their asthma meds 2Health News:Chicago Votes for Improved Healthcare with ZocDoc 2Health News:American Residential Law Group Urges Homeowners Not to “Go It Alone” During Mortgage Modification 2
(Date:7/31/2014)... 31, 2014   Auxilium Pharmaceuticals , Inc. (NASDAQ: ... company, today announced that the Company will release results ... 7, 2014 before the opening of the U.S. financial ... that day at 8:30 a.m. ET to discuss results ... presentation slides to be used during the call will ...
(Date:7/31/2014)... , July 31, 2014  Decision ... changes brought about by the Affordable Care ... and prescribing of pharmaceutical therapies. The ACA ... beneficiaries through new regulations and expanded access ... in the health exchanges—state-based marketplaces set up ...
(Date:7/31/2014)... 2014 Touro University California,s College of Pharmacy ... the recipient of a $150,000 grant by the Joseph ... to increase research and classroom space on its campus. ... the study of health sciences, and will help us ... interests of our students," said Shelley Berkley , ...
Breaking Medicine Technology:Auxilium Pharmaceuticals, Inc. To Announce Second Quarter 2014 Results On August 7, 2014 2Auxilium Pharmaceuticals, Inc. To Announce Second Quarter 2014 Results On August 7, 2014 3Health Exchanges Drive Change In MCO Strategies And Physician Prescribing Decisions; Impact On Pharma Mixed 2Health Exchanges Drive Change In MCO Strategies And Physician Prescribing Decisions; Impact On Pharma Mixed 3Health Exchanges Drive Change In MCO Strategies And Physician Prescribing Decisions; Impact On Pharma Mixed 4Touro University California Garners Grant From Long Foundation 2
... -- Global Information, Inc. (GII) presents " Computed Tomography ... Market Forecasts to 2017 " by GlobalData.  ... global Computed Tomography (CT) systems market to be worth ... systems and low-dose CT systems, the market is forecast ...
... -- Physicians, Capital Investments, LLC (PCI/the Company) a leader ... is pleased to announce that Becker,s ASC Review has ... in the ASC Industry to Know." This publication recognizes ... through their work with ASC-related companies, surgery centers and ...
Cached Medicine Technology:GiiResearch.com: Computed Tomography (CT) Systems - Technological Advances and Positive Clinical Trial Evidences to Drive the Market 2GiiResearch.com: Computed Tomography (CT) Systems - Technological Advances and Positive Clinical Trial Evidences to Drive the Market 3GiiResearch.com: Computed Tomography (CT) Systems - Technological Advances and Positive Clinical Trial Evidences to Drive the Market 4Physicians' Capital Investments Announces Pedro Vergne-Marini, MD Named to Becker's ASC Review "350 People in the ASC Industry to Know" 2Physicians' Capital Investments Announces Pedro Vergne-Marini, MD Named to Becker's ASC Review "350 People in the ASC Industry to Know" 3Physicians' Capital Investments Announces Pedro Vergne-Marini, MD Named to Becker's ASC Review "350 People in the ASC Industry to Know" 4
Galaxy Single Piece PMMA Lens with UV Absorber....
Liberty Single Piece PMMA Lens with UV Absorber....
Optical implants for the replacement of the human crystalline lens in the visual correction of aphakia....
... II is a sterile nonpyrogenic, transparent viscoelastic ... II contains 12 mg/ml of high molecular ... hyaluronate dissolved in physiological saline. In the ... is 105,000 cps (105 Pa s) at ...
Medicine Products: