Navigation Links
Researchers discover how to overcome poor response to radiotherapy caused by low haemoglobin levels
Date:5/11/2012

e survival, so that the differences between them and patients with normal Hb levels were no longer significant," says Professor Kaanders' colleague Dr. Geert Janssens. The difference in local control between this low Hb group and the normal Hb accelerated radiotherapy (AR) alone group was only 1% (81% in the ARCON group versus 82% in the AR-only group); for disease-free survival, the difference was 77% (ARCON) as opposed to 70% (AR); and for metastasis-free survival 93% (ARCON) versus 89% (AR).

However, patients in both groups with low Hb levels pre-treatment still had a worse overall survival irrespective of which treatment they received. This is most likely due the fact that many patients with head and neck cancer also have other health problems that cannot be treated by radiotherapy, the researchers say.

"In the past, a number of investigators have tried to improve the outcome for patients with low Hb levels by giving erythropoietin, which stimulates red blood cell production, and red cell blood transfusion before and during treatment, but without success. ARCON is the first treatment to be found to correct for low Hb and therefore to improve prognosis in these patients," says Dr. Janssens. "We know that a decrease in Hb levels is associated with a reduced sensitivity to radiotherapy, and that this can switch the tumour microenvironment into a more aggressive subtype with a higher risk of loco-regional failure and of the development of distant metastases."

The lack of success with transfusion of red blood cells or erythropoietin suggests underlying adaptive mechanisms. Accelerated radiotherapy to counteract tumour cell repopulation during radiotherapy, combined with carbogen and nicotinamide, administered immediately before irradiation to increase the oxygen level, ensures that adaptive mechanisms cannot erode the effect, and this is probably the key to success of the ARCON regime in patients with low HB levels at presentation, the re
'/>"/>

Contact: Mary Rice
mary.rice@riceconseil.eu
European Society for Radiotherapy and Oncology (ESTRO)
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers see BPA effects in monkey mammary glands
2. Geisel researchers sift through junk to find colorectal cancer clues
3. Email vacations decrease stress, increase concentration, researchers say
4. Researchers Rejuvenate Blood-Forming Stem Cells in Mice
5. CNIO researchers describe new functions of cohesin relevant for human disease
6. Biomedical researchers receive Hartwell Foundation awards
7. Kessler Foundation researchers present at first International Congress on Cognition in MS
8. Researchers gain better understanding of mechanism behind tau spreading in the brain
9. Moffitt Cancer Center researchers identify drivers of sarcoma growth and survival
10. Researchers determine vitamin D blood level for reducing major medical risks in older adults
11. Researchers creating designer lymph nodes based on Moffitts Total Cancer Care initiative
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Florida (PRWEB) January 22, 2015 Juvent ... today at the 2015 PGA Merchandise Show to bestow ... and incredible female amateur golfer, Arlene McKitrick. The award ... female amateur golf tournament win. She won her first ...
(Date:1/22/2015)... 22, 2015 Autocarinsurancebest.com has released a new ... commercial auto insurance policy . , Auto insurance quotes ... It is no longer necessary to call an agent or ... available online on a single website: http://autocarinsurancebest.com/ . , ...
(Date:1/22/2015)... Joan Lunden, award-winning American journalist, beloved television ... 32nd Annual Miami Breast Cancer Conference planned ... (PER®) , shares that “a fast-growing, virulent” cancer in ... had not followed up her clean mammogram with an ...
(Date:1/22/2015)... January 23, 2015 Recently, Weddingshe.com has added ... and has announced its highest annual revenues in the past ... its popular glamorous wedding dresses. , According to the sales ... wedding dress promotions for them in 2015. This point can ...
(Date:1/22/2015)... Payday lending practices in four southern states worsen ... to the states that permit them, according to a ... Race and Wealth. , While they generate hundreds of ... the same time substantially depress economic activity, according to ...
Breaking Medicine News(10 mins):Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2
... Dentists Insurance Company (TDIC) and TDIC Insurance Solutions have ... president and CEO. Richardson begins his new position on ... than 20 years of management, administrative, public policy and ... Deputy Commissioner for the California Department of Insurance. In ...
... WESTBROOK, Maine, May 28 IDEXX Laboratories, Inc. (Nasdaq: ... the William Blair & Company 29th Annual Growth Stock Conference. ... presentation on the Company on Tuesday, June 9, 2009 at ... Illinois. Individuals can access the live audio webcast of the ...
... Cerebral Palsy (UCP) of Central Arizona has been ... over twenty-five years. Locally and nationally Circle ... the organization that provides comprehensive programming to over ... cerebral palsy, autism, down syndrome, developmental delays and ...
... not certain that a broad-based immunization program will be ... vaccine for the H1N1 swine flu virus could be ... pace this summer, a leading U.S. health official said ... manufacturers. But federal officials will have to monitor the ...
... says it,s an improvement over fusion surgery , , THURSDAY, ... system that may preserve some range of motion in ... U.S. Food and Drug Administration. , The Scandinavian Total ... type and uses bearings that move across a surface ...
... of mission critical transportation, service/spare parts logistics, and integrated supply chain ... (FSL,s). , ... Broomfield, CO (Vocus) -- Network ... service/spare parts logistics , and integrated supply chain solutions ...
Cached Medicine News:Health News:TDIC and TDIC Insurance Solutions Select Former California Department of Insurance Deputy as CEO 2Health News:Children and Adults with Disabilities Benefit from Circle K's Unwavering Commitment 2Health News:Swine Flu Vaccine Won't Be Ready Until October: CDC 2Health News:Swine Flu Vaccine Won't Be Ready Until October: CDC 3Health News:Swine Flu Vaccine Won't Be Ready Until October: CDC 4Health News:Swine Flu Vaccine Won't Be Ready Until October: CDC 5Health News:Swine Flu Vaccine Won't Be Ready Until October: CDC 6Health News:Swine Flu Vaccine Won't Be Ready Until October: CDC 7Health News:Swine Flu Vaccine Won't Be Ready Until October: CDC 8Health News:Swine Flu Vaccine Won't Be Ready Until October: CDC 9Health News:Swine Flu Vaccine Won't Be Ready Until October: CDC 10Health News:Swine Flu Vaccine Won't Be Ready Until October: CDC 11Health News:Ankle Replacement System Lets Feet Move 2Health News:NGL Expands Global Network to Service Parts Logistics Customers 2Health News:NGL Expands Global Network to Service Parts Logistics Customers 3
(Date:1/23/2015)... 2015  iMD Companies, Inc. (ICBU) has repositioned itself as a ... grab a foothold in the hydroponic, hemp and medical marijuana ... presence in the sector, and recently partnering with the Chippewa ... and medical marijuana, iMD is committing to bring its vision ...
(Date:1/23/2015)... , Jan. 23, 2015   Leatt Corporation  (OTCQB: LEAT), ... equipment for all forms of sports, including extreme motor ... brace, announced today that the UISP Lega Motociclismo Lombardia, ... all riders to wear a neck brace during its ...
(Date:1/23/2015)... BIRMINGHAM, Ala. , Jan. 23, 2015 Gem ... (STS) patients have been enrolled into the Company,s Phase ... efficacy and safety of Gem,s lead compound, GPX-150 (an ... for advanced or metastatic disease. Logo - ...
Breaking Medicine Technology:iMD Companies Poised to Make Impact in Multi-Billion Dollar Medical Marijuana Sector With Recent Investments and Strategic Partnerships 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 3Gem Pharmaceuticals Announces Enrollment of Initial Patients in its Phase 2 Clinical Trial to Assess the Efficacy and Safety of GPX-150 in Sarcoma Patients 2
... WOONSOCKET, R.I. , May 13 CVS Caremark Corporation (NYSE: ... team will be speaking to investors at the Citi Investment Research 2010 ... Tom Ryan , Chairman and Chief Executive Officer, Larry Merlo , ... President and Chief Financial Officer, are scheduled to speak at approximately ...
... May 13 In its continued efforts to enhance physician ... Corp. ("Insight Imaging") (OTC Bulletin Board: ISGT) announced today that it ... MobileMD,s Health Information Exchange (HIE) provides secure real-time electronic orders and ... , , ...
Cached Medicine Technology:CVS Caremark to Participate in the Citi Investment Research 2010 Food & Drug Retail Conference 2Insight Imaging Selects MobileMD for Health Information Exchange Services 2Insight Imaging Selects MobileMD for Health Information Exchange Services 3
Inquire...
The Kowa Non-Contact Tonometer KT-800 comes with a one year parts and labor warranty....
The IR 1000 Insulin Infusion Pump from Animas offers unprecedented safety features, performance, and convenience....
... by LHE, provides excellent clinical results ... tool in the fight against acne, ... results usually within the first few ... its applications, SpaTouch Pro makes a ...
Medicine Products: