Navigation Links
Researchers discover hormone that controls supply of iron in red blood cell production
Date:6/1/2014

A UCLA research team has discovered a new hormone called erythroferrone, which regulates the iron supply needed for red blood-cell production.

Iron is an essential functional component of hemoglobin, the molecule that transports oxygen throughout the body. Using a mouse model, researchers found that erythroferrone is made by red blood-cell progenitors in the bone marrow in order to match iron supply with the demands of red blood-cell production. Erythroferrone is greatly increased when red blood-cell production is stimulated, such as after bleeding or in response to anemia.

The erythroferrone hormone acts by regulating the main iron hormone, hepcidin, which controls the absorption of iron from food and the distribution of iron in the body. Increased erythroferrone suppresses hepcidin and allows more iron to be made available for red blood-cell production.

"If there is too little iron, it causes anemia. If there is too much iron, the iron overload accumulates in the liver and organs, where it is toxic and causes damage," said senior author Dr. Tomas Ganz, a professor of medicine and pathology at the David Geffen School of Medicine at UCLA. "Modulating the activity of erythroferrone could be a viable strategy for the treatment of iron disorders of both overabundance and scarcity."

The early findings were reported online June 1 in the journal Nature Genetics.

"Our previous work anticipated that a regulator of hepcidin could be secreted by the bone marrow," said the study's first author, Leon Kautz, a postdoctoral fellow at UCLA. "In this research, we searched for new substances that were made in bone marrow that could fill that role."

Researchers first focused on what happens in the bone marrow after hemorrhage. From there, they focused on a specific protein that was secreted into the blood. This protein attracted their attention because it belonged to a family of proteins involved in cell-to-cell communication.

Using recombinant DNA technology, they showed that the hormone suppressed the production of hepcidin and demonstrated the effect it had on iron metabolism.

The team foresees that the discovery could help people with a common congenital blood disorder called Cooley's anemia, also known as thalassemia, which causes excessive destruction of red blood cells and of their progenitors in the bone marrow. Many of these patients require regular blood transfusions throughout their lives. Most iron overload is attributed to the iron content of transfused blood. However, even patients who are rarely, or never, transfused can also develop iron overload.

"Overproduction of erythroferrone may be a major cause of iron overload in untransfused patients and may contribute to iron overload in transfused patients," said study author Elizabeta Nemeth, a professor of medicine at the David Geffen School of Medicine at UCLA and co-director of the UCLA Center for Iron Disorders. "The identification of erythroferrone can potentially allow researchers and drug developers to target the hormone for specific treatment to prevent iron overload in Cooley's anemia."

The discovery could also lead to treatments for other common anemia-related conditions associated with chronic kidney disease, rheumatologic disorders and other inflammatory diseases. In these conditions, iron is "locked up" by the effect of the hormone hepcidin, whose levels are increased by inflammation. Erythroferrone, or drugs acting like it, could suppress hepcidin and make more iron available for red blood-cell production.

The next stage of research is to understand the role of the new hormone in various blood diseases and study the molecular mechanisms through which erythroferrone regulates hepcidin.


'/>"/>
Contact: Amy Albin
aalbin@mednet.ucla.edu
310-794-8672
University of California - Los Angeles Health Sciences
Source:Eurekalert  

Related medicine news :

1. Mount Sinai researchers to present studies at American Society of Clinical Oncology Meeting
2. JAX cancer researchers awarded NCI provocative questions grants
3. Nationally-recognized health policy researchers and experts convene in San Diego June 8-10
4. Researchers address major geographic disparities in access to kidney transplantation
5. Mount Sinai researchers lead committee to define the clinical course of multiple sclerosis
6. NYU researchers pilot educational and behavioral program to reduce lymphedema risk
7. UCI researchers identify new functional roles on cell surfaces for estrogen
8. Researchers identify a new suppressor of breast metastasis to the lung
9. Researchers identify key mechanism in metabolic pathway that fuels cancers
10. Drug-target database lets researchers match old drugs to new uses
11. Finnish researchers discovered a new anticancer compound
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers discover hormone that controls supply of iron in red blood cell production
(Date:3/23/2017)... ... 2017 , ... Sharon Kleyne, host of the nationally syndicated radio program, The ... recently talked on her program about how she is looking forward to World Water ... an important distinction. World Water Day, Kleyne pointed out, is an occasion for looking ...
(Date:3/23/2017)... ... March 23, 2017 , ... It’s that time of year ... are thinking about summer internships , which can be frustrating when they don’t ... at Garden Media Group, a boutique public relations firm outside of Philadelphia, have offered ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... The American ... 2017 marks the 40th Anniversary of ABQAURP’s dedication to Health Care Quality and Management ... who have contributed not only to the association, but also to the Health Care ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... Task Force Dagger Foundation the US Special Operations Command’s Patriot Award. The award ... General Thomas thanked Task Force Dagger Foundation for its significant and enduring support ...
(Date:3/23/2017)... ... March 23, 2017 , ... GeBBS Healthcare Solutions unveils the ... 21st annual Compliance Institute on March 26-28 in National Harbor, Maryland. ... chart types with a comprehensive set of features including built-in workflow, interactive audit ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)...  Drug diversion is a significant contributing factor ... A new oral fluid monitoring test, announced today ... more detailed and actionable information to clinicians than ... adherence, patient safety, and help to identify drug ... Rx Evaluation (CORE) system is the first patient-monitoring ...
(Date:3/23/2017)... 2017 Ascendis Pharma A/S (Nasdaq: ASND), a ... address significant unmet medical needs in rare diseases, today ... and webcast on Monday, April 3 during ENDO 2017, ... Orlando, Florida , to discuss new data ... Hormone, TransCon PTH and TransCon CNP). Ascendis ...
(Date:3/23/2017)...  A new genetic test has been discovered ... who carry HLA-B*15:02 and who are ... deadly side effect of certain medications used to ... HLA-B*15:02 is strongly associated with life-threatening severe ... toxic epidermal necrolysis in patients treated with carbamazepine ...
Breaking Medicine Technology: