Navigation Links
Researchers discover gender-based differences in Alzheimer's disease
Date:11/25/2012

CHICAGO All patients with Alzheimer's disease (AD) lose brain cells, which leads to a shrinking, or atrophy, of the brain. But the pattern of gray matter loss is significantly different in men and women, according to a study presented today at the annual meeting of the Radiological Society of North America (RSNA).

"We found that the extent and distribution of regional gray matter volume loss in the brain was strongly influenced by gender," said lead researcher Maria Vittoria Spampinato, M.D., associate professor of radiology at the Medical University of South Carolina in Charleston.

According to the Alzheimer's Association, 5.4 million Americans have AD, the sixth-leading cause of death in the U.S. Currently, there is no cure for AD, which lends urgency to research efforts designed to better understand, diagnose and treat this devastating illness.

"There is a strong interest in using magnetic resonance imaging (MRI) to assess brain atrophy with the purpose of monitoring dementia progression noninvasively and to aid in understanding which factors can influence brain atrophy progression and distribution in the Alzheimer's brain," Dr. Spampinato said.

In the study, Dr. Spampinato and colleagues analyzed data on 109 patients, including 60 men and 49 women (mean age 77), who participated in the Alzheimer's Disease Neuroimaging Initiative (ADNI), a major study that followed hundreds of cognitively healthy individuals and individuals with mild cognitive impairment (MCI) and AD over a period of five years.

During the five-year period, each of the 109 patients progressed from amnestic MCI (in which the patient suffers memory loss but maintains cognitive function) to AD. Using MR images of the patients' brains taken when they were diagnosed with AD and 12 months before and after the diagnosis, the researchers created brain maps that illustrated gray matter changes.

The brain maps revealed that compared to male patients, the women had greater atrophy in gray matter 12 months prior to their AD diagnosis and at the time of their diagnosis. The brain maps also showed that the men and women in the study lost gray matter volume in different areas of the brain as their disease progressed from MCI to AD.

"The female patients in our study initially had more gray matter atrophy than the male patients but over time, the men caught up," Dr. Spampinato said. "In the men, the disease developed more aggressively in a shorter period of time."

Dr. Spampinato said the gender differences in atrophy patterns have important implications for the development of therapies for MCI and AD.

"These differences should be taken into consideration when testing new drugs in clinical trials," she said. "Knowing the difference between the male and female patterns of atrophy will help researchers better decipher a patient's response to drug therapy."


'/>"/>

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... , ... February 24, 2017 , ... With ProGlass Prism ... Pro X . Users have total control over position, rotation, distortion, edge softness, edge ... within Final Cut Pro X. , With ProGlass Prism users are given the tools ...
(Date:2/24/2017)... ... 24, 2017 , ... The Radiology Business Management Association will select ... the annual Building Better Radiology Marketing Programs conference, held this year from ... Texas. Nine awards are given out in five categories. They are:, ...
(Date:2/23/2017)... ... February 23, 2017 , ... ... jointly issued a letter to withdraw previous guidance issued by the ... identity. The guidance issued in May 2016 by the Obama Administration came in ...
(Date:2/23/2017)... CA (PRWEB) , ... February 23, 2017 , ... Los ... two episodes of WE TV’s “Mama June: From Not to Hot,” which will begin ... notable, “Mama” June Shannon, known to millions from the 2012 reality television series, “Here ...
(Date:2/23/2017)... (PRWEB) , ... February 23, 2017 , ... Dr. David ... in Henderson, NV 89052. Dr. Mahon was named a 2017 Top Patient Rated ... is an online directory that recognizes local physicians and dentists who have earned ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... China , 23. Februar 2017 Im ... , eine nationale Wirtschaftszone in der südwestlichen chinesischen Provinz Guizhou, ... der Errichtung einer Innovationsplattform aktiv an der Entwicklung einer eingebetteten ... Continue Reading ... ...
(Date:2/23/2017)... 23, 2017 AcelRx Pharmaceuticals, Inc. (Nasdaq: ... development and commercialization of innovative therapies for the ... will release fourth quarter and yearly financial results ... AcelRx management will host an investment-community conference call ... Time) on March 2 nd 2017 to ...
(Date:2/23/2017)... , February 23, 2017 According ... by Product (X-ray Imaging Digital, Analog), MRI (Closed, Open), ... MSK, Cardiology, Oncology), End User (Hospitals, Imaging Centers) - ... studies the global market over the forecast period of ... ~USD 36.43 Billion by 2021, at a CAGR of ...
Breaking Medicine Technology: