Navigation Links
Researchers discover brain tumor's 'grow-or-go' switch
Date:3/11/2010

COLUMBUS, Ohio Cancer cells in rapidly growing brain tumors must adjust to periods of low energy or die. When energy levels are high, tumor cells grow and proliferate. When levels are low, the cells grow less and migrate more.

Researchers at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute have discovered the switch responsible for this grow-or-go behavior.

Their study shows that a molecule called miR-451 coordinates the change, and that the change is accompanied by slower cell proliferation and an increase in cell migration.

This behavior was closely linked to the cancer's ability to invade and spread. For this reason the molecule might serve as a biomarker to predict how long patients with the brain tumor glioblastoma multiforme will survive and may serve as a target to develop drugs to fight these tumors.

The researchers found that glioblastoma cells shift from their typical means of metabolizing glucose a sugar brought by the bloodstream and usually used for energy to an alternate means that consumes resources within the cell.

The findings are published in the March 12 issue of the journal Molecular Cell. "

Our study reveals how brain tumor cells adapt to their surroundings and survive conditions that might fatally starve them of energy," says co-author Dr. E. Antonio Chiocca, professor and chair of Neurological Surgery at Ohio State. "We have discovered that glioblastoma cells use miR451 to sense the availability of a nutrient glucose.

"Levels of miR-451 directly shut down the engine of the tumor cell if there in no glucose or rev it up if there is lots of glucose. This important insight suggests that this molecule might be useful as a biomarker to predict a glioblastoma patient's prognosis, and that it might be used as a target to develop drugs to fight these tumors."

About 10,000 new cases of glioblastoma multiforme occur annual
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Exposure to BPA may cause permanent fertility defects, Yale researchers find
2. MRI finds tumors in second breast of women diagnosed with cancer in one breast, Mayo researchers say
3. Researchers find further evidence linking Epstein-Barr virus and risk of multiple sclerosis
4. Learning keeps brain healthy, UCI researchers find
5. Sea Squirt Helps Researchers Test New Alzheimers Drug
6. UMass Lowell researchers findings suggest new ways to diagnose and treat Alzheimers
7. Researchers find that sociodemographic characteristics are related to a patients willingness to participate in cancer screenings
8. Veterans Affairs Researchers Induce a New Transmissible Prion Disease
9. New Building at University of Michigan Health System Expands Eye Care, Unites Diabetes Researchers
10. Multiple sclerosis, Italian researchers discover a possible onset mechanism for the disease
11. HIV drug that protects a fetus should be avoided for one year after childbirth, researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... December 25, 2014 AlignLife of Wauwatosa ... to afford certain items. During the holiday season, AlignLife looks ... over 70 toys," says Dr. Sara Mahalko-Leonhardt, owner of AlignLife. ... such joy, knowing that we are able to give kids ... it not been for the generosity of our patients." , ...
(Date:12/24/2014)... 2014 Recently, iFitDress.com, a famous dress manufacturer ... dresses under $150 . All these items are brand new; ... has already been updated with the new range of high ... so far. All iFitDress.com’s designs are made according to the ... great materials. Every outfit from the company is handpicked by ...
(Date:12/24/2014)... York (PRWEB) December 24, 2014 ... ) that allege the blood thinner caused life-threatening ... outlined a leadership structure for the proceeding, Bernstein ... December 17th, the Court plans to select lawyers ... and also plans on appointing a Plaintiffs’ Steering ...
(Date:12/24/2014)... Oregon (PRWEB) December 24, 2014 ... Rehab sat down with Derek Fenwick, PT, MBA, ... changes that will stem from the passing of the ... (IMPACT Act). In this taping of the Infinicast, ... title XVIII of the Social Security Act to standardize ...
(Date:12/24/2014)... Dec. 24, 2014 (HealthDay News) -- Hepatitis C infection does ... to a new study. Treatment advances have made it ... many develop memory and thinking problems, mood swings and other ... said. It,s believed that long-term infections with other viruses ... affect the brain. One of the prime suspects has been ...
Breaking Medicine News(10 mins):Health News:AlignLife of Wauwatosa Brings Joy to Less Fortunate Families 2Health News:Many Prom Dresses under 150 from Well-known Dress Manufacturer iFitDress.com 2Health News:Court Overseeing Federal Xarelto Lawsuits Issues Coordination Order, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal Xarelto Lawsuits Issues Coordination Order, Bernstein Liebhard LLP Reports 3Health News:Latest Episode of Infinicast Features Infinity Rehab President Discussing IMPACT Act of 2014 and Changes for Post-Acute Therapy Providers in 2015 2Health News:Hepatitis C Infection Isn't Related to HIV Brain Woes: Study 2
... -- A fetus is sensitive to, and can be affected ... University of California, Irvine, researchers recruited pregnant women and ... The women,s babies were tested after birth to assess how ... state appeared to be important to a baby,s well-being. Development ...
... , THURSDAY, Nov. 17 (HealthDay News) -- ... severe mood dysregulation spend less time looking at the ... children without the psychiatric disorders, researchers say. This ... bipolar disorder and severe mood dysregulation have difficulty determining ...
... who identify themselves as such in the workplace are ... their job than transsexuals who do not, according to ... University. "Trans-parency in the Workplace: How the ... in an upcoming issue of the Journal of ...
... that has set standards for teaching women and clinicians ... around the country to detect lumps earlier and save ... of early detection of cancer. The Center for Disease ... cancer is the most common cancer among American females. ...
... 2011 InDevR, a Boulder-based biotechnology company that ... analysis of viruses and other microorganisms, announced today ... ampliPHOX, a colorimetric detection system that incorporates core ... Transfer Office, will enhance laboratories around the world ...
... 17 (HealthDay News) -- Young athletes who routinely take hits ... they do not suffer a concussion, according to the results ... of Rochester Medical Center (URMC) said their findings could be ... mild head injuries among young people whose brains are still ...
Cached Medicine News:Health News:Mom-to-Be's Mental State May Affect Child's Development 2Health News:Bipolar Kids May Focus on Different Facial Features 2Health News:'Trans-parency' in the workplace 2Health News:Indevr launches breakthrough colorimetric detection for microarrays using core technology from CU 2Health News:Routine Head Hits in Sports May Injure Brain, Experts Warn 2
(Date:12/24/2014)... 23, 2014  Medical Science Liaisons play a large ... between the medical device industry and key stakeholders, the ... coming years as the device industry relies on them ... research by benchmarking firm, Best Practices, LLC, one area ... edge is by harnessing new technology to enable education. ...
(Date:12/22/2014)... NxStage Medical, Inc. (NASDAQ: NXTM ... announced today that the U.S. Food and Drug ... perform hemodialysis overnight while the patient is at ... System One is the first and only hemodialysis ... Home nocturnal hemodialysis is an ...
(Date:12/22/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/h3xm6q/us ) has ... Glucose Market" report to their offering. ... insight focuses on the developments in the self-monitoring blood ... . Reimbursement analysis and the effects of competitive bidding ... 73 SMBG meters have been performed, based on the ...
Breaking Medicine Technology:Role of Medical Science Liaisons Evolving in Medical Device Sector 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 3US Self-monitoring Blood Glucose Market 2
... innovative & portable FireFly LED light offers ... With the new FireFly LED you'll get ... go whereever your practice demands. High center-beam ... on your procedures, while the rechargeable battery ...
... LED headlight provides superior Illumination in an ... you'll get bright center-beam light with a ... direct it all totally hands free. ... quality materials to fit any manufacturers loupe ...
Easy pull-on garment's feature Rainey's exclusive Non-Slip Dome™design and adjustable Velcro© closure at neck for optimal comfort and support. Choose covered or non covered ear design....
For face-lifts and submental liposuction...
Medicine Products: