Navigation Links
Researchers discover biological diversity in triple-negative breast cancer
Date:2/13/2013

CHAPEL HILL, N.C. Triple-negative breast cancers are more biologically diverse than previously believed and classification should be expanded to reflect this heterogeneity, according to University of North Carolina researchers.

In a study published in the February issue of The Oncologist conducted by UNC and the Vall d'Hebron Institute of Oncology in Barcelona, Spain, a team lead by Charles Perou, PhD, of UNC Lineberger Comprehensive Cancer Center, examined more than 1,700 breast tumors, including 412 triple negative (TN) breast cancers, and concluded that triple-negative cancers, and basal-like breast cancers should not be considered as a single type, since more than 30 percent of triple-negative cancers lack biological markers associated with basal-like tumors.

Breast cancers are sometimes classified into four main subtypes basal-like (often called TN), luminal A, luminal B and HER2-enriched. While targeted therapies have been developed to exploit the weaknesses of some types of breast cancers, the lack of these drug markers on TN cancers means patients with these tumors must undergo broader, more aggressive therapies.

"This is clinically very important, because TN breast cancers lack the three biomarkers used for guiding many therapies in breast cancer, so those patients do not have these therapeutic options. They are thus left with multi-agent chemotherapy as their treatment," said Dr. Perou.

The researchers found at least four disease subtypes within TN tumors, with more than 75 percent of the tumors falling into the basal-like subtype. Further research is needed to identify the distinct biomarkers shared by the expanded subtypes of TN cancers. The ultimate goal will be to target the individual biomarkers of these subtypes and create therapies that target their individual biology, according to Dr. Perou.

"Today, given that the Basal-like subtype is the majority of TN patients, I believe that if we are to make therapeutic progress against TN disease, we are going to need to target the unique biology of the Basal-like subtype" said Dr. Perou.


'/>"/>

Contact: William Davis
william_davis@med.unc.edu
919-962-3405
University of North Carolina Health Care
Source:Eurekalert  

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers discover biological diversity in triple-negative breast cancer
(Date:5/21/2017)... ... May 21, 2017 , ... For more than 20 ... a wide range of knives and swords, from functional to fantasy. United Cutlery has ... with sleek, modern designs that defy tradition. , Offering a range of weapons and ...
(Date:5/19/2017)... ... ... In a continuous effort to raise awareness of autism and common toxins ... in natural and organic latex mattresses, has announced that they will donate $1 to ... their recent viral Facebook video receives, up to $10,000.00. , The luxury ...
(Date:5/19/2017)... Mo (PRWEB) , ... May 19, 2017 , ... When ... May 20, his name will already appear on two major research studies that could ... been working with Dr. Matt Daggett, KCU alumnus and an orthopedic surgeon, alongside an ...
(Date:5/19/2017)... ... May 19, 2017 , ... ... retirement planning assistance to families and business owners in the region, is embarking ... for MS sufferers and their families. , Multiple sclerosis (MS) is a demyelinating ...
(Date:5/19/2017)... Atlanta, GA (PRWEB) , ... May 19, 2017 , ... ... D. Miller knows the importance of prostate cancer screenings. Early detection of the ... Miller, head of robotic surgery at Georgia Urology , stands alongside the Georgia ...
Breaking Medicine News(10 mins):
(Date:5/18/2017)... , May 18, 2017  Two Bayer U.S. ... Association (HBA) during its recent 28 th ... City.  The event showcases HBA,s longstanding mission of furthering ... of healthcare. Cindy Powell-Steffen , senior ... U.S. Radiology division, and Libby Howe , a ...
(Date:5/12/2017)... 12, 2017  The China and Canada ... consumes less water, energy and detergent, and features a powerful disinfection ... a shoebox-sized washing machine that washes and sanitizes women,s panties or ... ... compact, and does not require an external water inlet. ...
(Date:5/10/2017)... -- The Corporate Whistleblower Center says, "We are urging ... to call us anytime at 866-714-6466 if they possess ... a substantial scheme to overbill Medicare. We are ... of a medical equipment company if their employer ... practice groups with extra generous incentives to use, or ...
Breaking Medicine Technology: