Navigation Links
Researchers discover Achilles' heel in lethal form of prostate cancer
Date:11/16/2011

NEW YORK -- An international team of researchers led by clinicians at Weill Cornell Medical College have discovered a genetic Achilles' heel in an aggressive type of prostate cancer -- a vulnerability they say can be attacked by a targeted drug that is already in clinical trials to treat other types of cancers.

In today's issue of Cancer Discovery, the researchers report that the investigational drug had a dramatic response in animal models of neuroendocrine prostate cancer, and so provides the first hope of an effective human therapy for this lethal cancer. While fewer than 2 percent of prostate tumors in men are initially classified as neuroendocrine, many common adenocarcinoma prostate cancers change their biology during hormone therapy and morph into this aggressive subtype.

The study is the largest in-depth analysis of neuroendocrine prostate cancer yet undertaken, and the findings "are very exciting, because our bench-to-bedside approach identified a new molecular target for a subtype of prostate cancer for which a drug is now available," says the study's senior investigator, Dr. Mark A. Rubin, a professor of pathology and laboratory medicine at Weill Cornell Medical College and a pathologist at NewYork-Presbyterian Hospital/Weill Cornell Medical Center.

The finding is especially important because many men are now being treated with new, highly potent androgen suppression therapy, which these researchers believe will significantly increase the risk of future development of neuroendocrine tumors. Androgen is the fuel that feeds adenocarcinoma prostate cancers -- the most common kind of prostate cancer -- and androgen suppression therapy effectively destroys cancer cells that depend on this hormone. But the treatment does not touch neuroendocrine cells that may have been part of the tumor mix, and those untreatable cells now have room to grow and spread, the researchers say.

Although most of the approximately 30,0
'/>"/>

Contact: John Rodgers
jdr2001@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Jackson Laboratory researchers uncover steps in synapse building, pruning
2. UCLA stem cell researchers uncover mechanism that regulates human pluripotent stem cell metabolism
3. Ben-Gurion University of the Negev researchers achieve male fertility breakthrough
4. Canadian researchers find potential new leukemia treatment with old antibiotic drug
5. FDA funds Rochester researchers to give chronic and acute pain clinical trials a makeover
6. Jefferson researchers study outcomes of carotid artery stenting following prior carotid procedure
7. Researchers gain insight into 100-year-old Haber-Bbosch process
8. New funding will help researchers learn how preschoolers move, battle early child obesity
9. Pitt researchers using mathematics to target Parkinsons disease symptoms
10. Moffitt Cancer Center researchers unravel biochemical factor important in tumor metastasis
11. Lose the fat and improve the gums, CWRU dental researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2014)... (SALT LAKE CITY)A computational tool developed at the University ... with unknown gene mutations in three separate cases, U ... new study in The American Journal of Human ... Re-ranking tool), identifies undiagnosed illnesses and unknown gene mutations ... proteins that code for genes are made, in individual ...
(Date:4/22/2014)... available in German . ... the University of Vienna and the Medical University of Vienna, ... how double stranded RNA, such as viral genetic information, is ... immune response against viral infection, the protein ADAR1 moves from ... viral RNA to inhibit reproduction of the virus. But how ...
(Date:4/22/2014)... be influenced by low exposure to testosterone in the ... how men,s testosterone levels may be determined before they ... of the hormone than others is important because testosterone ... the hormone have been linked to obesity, diabetes and ... responsible for producing testosterone in adults known as ...
(Date:4/22/2014)... most of us have gotten stuck in a check-out ... Will Mather, assistant professor of physics and an instructor ... lines, or queues, has been crucial in trying to ... recycling of proteins. , The work, submitted during Mather,s ... from the National Science Foundation in the form of ...
(Date:4/22/2014)... of Calgary,s Hotchkiss Brain Institute (HBI) uncovers a mechanism ... means to restore connections after injury. Dr. Doug Zochodne ... directly regulates nerve cell growth in the damaged nervous ... Nature Communications , with lead authors Drs. Kim ... surprising discovery that a protein called Retinoblastoma (Rb) is ...
Breaking Medicine News(10 mins):Health News:Applying math to biology: Software identifies disease-causing mutations in undiagnosed illnesses 2Health News:Applying math to biology: Software identifies disease-causing mutations in undiagnosed illnesses 3Health News:How the body fights against viruses 2Health News:How the body fights against viruses 3Health News:Queuing theory helps physicist understand protein recycling 2Health News:Scientists discover a new way to enhance nerve growth following injury 2
... the hepatobiliary system is blocked bile ducts. However, artificial ... are medical implants which reopen narrowed bile ducts to ... catheters forming dense communities, so-called biofilms. Inside these biofilms, ... initiated by the host but also from antibiotics. ...
... New research presented at the 17th European Congress ... Plate(R) vibration plate exercise machines in conjunction with a ... harmful belly fat. The study(i), conducted at the University ... who regularly undertook Power Plate(R) exercise were more successful ...
... Institute recognized five hospitals and health systems with Shining Star ... made significant contributions that ultimately make a positive impact on the ... Baylor Health Care System in Dallas, TX, ... vendors. , Meridian Health ...
... to better treatments, scientists say , , SUNDAY, May 10 ... what researchers describe as a treasure trove of genes ... swoop, to find so many genes related to blood ... of one of the studies, Dr. Christopher Newton-Cheh, an ...
... 11 Covance Inc. (NYSE: CVD ) today ... Conference on Tuesday, May 12, 2009 at 4:40 p.m. (ET). ... at www.covance.com . In order to ... minutes early.Covance, with headquarters in Princeton, New Jersey, is one ...
... IDM Pharma, Inc. (Nasdaq: IDMI ) today ... Financial information presented represents the consolidated results of IDM ... and cash equivalents was $7.4 million as of March 31, ... In order to focus on those areas we believe can ...
Cached Medicine News:Health News:Thus the bile does not overflow 2Health News:New Study Finds Power Plate(R) Exercise Aids in Weight Loss, Reduction of Harmful Visceral Fat 2Health News:Five Healthcare Organizations Honored as 'Shining Stars' by The Beryl Institute 2Health News:Genes Yield Clues to High Blood Pressure 2Health News:Genes Yield Clues to High Blood Pressure 3Health News:IDM Pharma Reports First Quarter Financial Results 2Health News:IDM Pharma Reports First Quarter Financial Results 3Health News:IDM Pharma Reports First Quarter Financial Results 4Health News:IDM Pharma Reports First Quarter Financial Results 5Health News:IDM Pharma Reports First Quarter Financial Results 6Health News:IDM Pharma Reports First Quarter Financial Results 7
(Date:1/14/2014)... HARRISBURG, Pa. , Jan. 14, 2014 Dynamic Healthcare ... ("GMH"), announced today that it acquired Progressive Home Medical Equipment, ... January 7, 2014. The terms of the acquisition were not ... medical equipment ("DME") company providing a wide range of sleep, ...
(Date:1/14/2014)... , Jan. 14, 2014 Animal Emergency Critical Care, a ... Leesburg, Virginia is the first in ... chamber. Dr. Susan M. Barnes , Medical ... Barnes and husband, Dr. Cole Taylor , are avid scuba ...
(Date:1/14/2014)... , Jan. 14, 2014 NineSigma , ... hold its Innovation Leadership Summit , May 14-16, ... Cleveland Ohio . ... and organizations committed to breakthrough achievements through open innovation. ...
Breaking Medicine Technology:Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 4
... Calif., Sept. 16, 2011 Accuray Incorporated (Nasdaq: ... its management is scheduled to present at the UBS Global ... 2011 at 4:30 p.m. ET/1:30 p.m. PT. A ... the investor relations page of the Company,s Web site at ...
... Unilife Corporation ("Unilife" or "Company") (NASDAQ: UNIS, ASX: UNS), today ... Global Life Sciences Conference in New York City. Alan Shortall, ... 1:00 p.m. EDT on Monday, September 19, 2011 (Tuesday, ... conference presentation will be broadcast over the Internet as a ...
Cached Medicine Technology:Unilife to Present at the 2011 UBS Global Life Sciences Conference in New York City 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: