Navigation Links
Researchers developing new test to measure risk for birth defects and neuro-developmental disorders

Researchers at SUNY Downstate Medical Center have received a $50,000 grant from the SUNY Research Foundation Technology Accelerator Fund to develop a diagnostic test for the folate receptor autoantibody. This autoantibody is associated with neural tube defects, subfertility, cerebral folate deficiency in infants and autism spectrum disorders.

Among the most common birth defects in the United States, neural tube defects result in the brain and spinal cord not developing properly. Affected babies may be partially paralyzed for life, or worse, can die in utero or shortly after birth. The nutrient folate plays a key role in neural tube defects. Public health campaigns emphasizing the importance of a diet rich in folate and the taking of folate supplements during pregnancy have reduced the incidence of neural tube defects dramatically.

Edward Quadros, PhD, research professor of medicine, and research scientist Jeffrey Sequeira, MS, have been studying a biomarker for folate problems called folate receptor (FR) autoantibodies. The antibodies appear to block nutritional folate from entering cells that need them or they trigger an immune response that counteracts the effects of folate. In addition to playing a causative role in neural tube defects, the FR antibodies have been implicated in autism and other neurodevelopmental diseases, such as Rett syndrome and cerebral folate deficiency syndrome, and subfertility.

Dr. Quadros has created a test for FR antibodies, an ELISA-based assay, which he hopes to develop into a clinically useful tool to diagnose the risk of folate-related problems for women of childbearing age as well as in young children with neuro-developmental disorders. Autism, which occurs in one in 100 children, is not usually diagnosed until the children are around two years old. By helping to identify women and children at risk for folate-related problems, the test could alert physicians to prescribe folate supplements for these patients.

Dr. Quadros says, "The potential impact of this test is the prevention of neural tube defects as well as a whole range of neurodevelopmental and autism spectrum disorders."

The State University of New York and the Research Foundation created the SUNY Technology Accelerator Fund (TAF) to support innovation across the SUNY research community. TAF assists the SUNY community by providing funding to accelerate the development and commercialization of promising technologies. Five diverse proposals were selected to receive a total of $250,000 in funding for this first round of TAF awards.


Contact: Ron Najman
SUNY Downstate Medical Center

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
(Date:12/1/2015)... ... December 01, 2015 , ... ... as a Modern Man for 2015. , Angeleno Magazine is a division ... States. Established in 1994, Modern Luxury includes more than 50 magazine titles across ...
(Date:12/1/2015)... , ... December 01, 2015 , ... ... Center Enterprise Authorized Technology Provider (ATP) status from Cisco. This designation recognizes Tympani ... support Cisco Unified Contact Center solutions targeted to the high-end enterprise contact center ...
(Date:11/30/2015)... , ... November 30, 2015 , ... ... Beard and Brooke Bennett are collaborating with brands across various categories through traditional ... influential figures make up an elite group of Gold Medal Moms who can ...
(Date:11/30/2015)... & Caicos Islands, BWI (PRWEB) , ... December 01, 2015 , ... ... 2015. Recently Caribbean Journal, one of the leading digital news sites highlighting Caribbean ... top reason? The weather. While much of North America shivers under chilly grey ...
(Date:11/30/2015)... Garden City, NY (PRWEB) , ... December 01, 2015 , ... ... as a 2015-2016 inductee into its VIP Woman of the Year Circle. She ... is the nation’s leading networking organization exclusively for professional women, boasting more than 850,000 ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... , BANGALORE, India and ... -- Mylan N.V. (NASDAQ, TASE: MYL) today announced that it ... approval and for developing country markets funded by international ... 300 mg + Efavirenz 400 mg) for $99 per ... Access Initiative (CHAI) to develop TLE400. The significantly reduced ...
(Date:12/1/2015)... diciembre de 2015  AccuTEC Blades, una ... precisión, develó hoy un nuevo logo corporativo ... El nuevo logo destaca la experiencia de ... de productos con cuchillas donde "el borde ... --> ...
(Date:12/1/2015)... 2015 Breg, Inc ., a premier ... that it has been awarded three contracts by Novation, ... Novation will have access to improved pricing for Breg,s ... soft goods dedicated to advancing orthopedic care.  ... U.S. population, rising prevalence of chronic conditions and the ...
Breaking Medicine Technology: