Navigation Links
Researchers developing new test to measure risk for birth defects and neuro-developmental disorders
Date:8/25/2011

Researchers at SUNY Downstate Medical Center have received a $50,000 grant from the SUNY Research Foundation Technology Accelerator Fund to develop a diagnostic test for the folate receptor autoantibody. This autoantibody is associated with neural tube defects, subfertility, cerebral folate deficiency in infants and autism spectrum disorders.

Among the most common birth defects in the United States, neural tube defects result in the brain and spinal cord not developing properly. Affected babies may be partially paralyzed for life, or worse, can die in utero or shortly after birth. The nutrient folate plays a key role in neural tube defects. Public health campaigns emphasizing the importance of a diet rich in folate and the taking of folate supplements during pregnancy have reduced the incidence of neural tube defects dramatically.

Edward Quadros, PhD, research professor of medicine, and research scientist Jeffrey Sequeira, MS, have been studying a biomarker for folate problems called folate receptor (FR) autoantibodies. The antibodies appear to block nutritional folate from entering cells that need them or they trigger an immune response that counteracts the effects of folate. In addition to playing a causative role in neural tube defects, the FR antibodies have been implicated in autism and other neurodevelopmental diseases, such as Rett syndrome and cerebral folate deficiency syndrome, and subfertility.

Dr. Quadros has created a test for FR antibodies, an ELISA-based assay, which he hopes to develop into a clinically useful tool to diagnose the risk of folate-related problems for women of childbearing age as well as in young children with neuro-developmental disorders. Autism, which occurs in one in 100 children, is not usually diagnosed until the children are around two years old. By helping to identify women and children at risk for folate-related problems, the test could alert physicians to prescribe folate supplements for these patients.

Dr. Quadros says, "The potential impact of this test is the prevention of neural tube defects as well as a whole range of neurodevelopmental and autism spectrum disorders."

The State University of New York and the Research Foundation created the SUNY Technology Accelerator Fund (TAF) to support innovation across the SUNY research community. TAF assists the SUNY community by providing funding to accelerate the development and commercialization of promising technologies. Five diverse proposals were selected to receive a total of $250,000 in funding for this first round of TAF awards.


'/>"/>

Contact: Ron Najman
ron.najman@downstate.edu
718-270-2696
SUNY Downstate Medical Center
Source:Eurekalert

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, a ... and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is ... to some of the world’s leading providers of cereal and other breakfast foods. Its ...
(Date:6/26/2016)... Birmingham, Lake Orion, Clarkston, Michigan (PRWEB) , ... ... ... their direction with respect to fertility once they have been diagnosed with endometriosis. ... for tolerable intercourse but they also require a comprehensive approach that can help ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, ... Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms ... Final Cut Pro X . Simply select a ProHand generator and drag it above ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of ... recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at Work ... Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... June 19, ... the dangers associated with chronic pain and the benefits of holistic treatments, Serenity ... who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical ... the "Company"), which develops, markets and sells medical devices ... , signed a strategic cooperation agreement with Hongyuan ... "Hongyuan Supply Chain") on June 20, 2016, to develop ... the strategic cooperation agreement, Dehaier will leverage Hongyuan Supply ...
(Date:6/24/2016)... June 24, 2016 Research and Markets ... for Companion Diagnostic Tests" report to their offering. ... Companion Diagnostics The World Market for Companion ... medicine diagnostics. Market analysis in the report includes the following: ... (In Vitro Diagnostic Kits) by Region (N. America, EU, ROW), ...
(Date:6/24/2016)... Mass. , June 24, 2016   Pulmatrix, ... pharmaceutical company developing innovative inhaled drugs, announced today that ... Russell Investments reconstituted its comprehensive set of ... "This is an important milestone for Pulmatrix," ... will increase shareholder awareness of our progress in developing ...
Breaking Medicine Technology: