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Researchers developing antiviral drug to combat contagious norovirus
Date:3/25/2013

ors. We know that certain basic structures on our protease inhibitors are effective at inhibiting norovirus, so we continue to generate more compound derivatives based on these basic structures. A compound needs to be effective in enzyme assay and cell-based assay. The compounds also need to have very good pharmacokinetics. We are confident that our compounds can go further than the laboratory."

The scientists also are performing basic virology studies to advance their work further. They are studying how the compounds bind to the virus protease and inhibit protease function using X-ray crystallography and other enzymology tools. In addition, the scientists are investigating other potential targets for developing anti-norovirus drugs, such as host factors to diversify their approaches to norovirus control.

The researchers have filed a patent application for their research. They have published more than 20 papers in the last four years, including articles in the Journal of Virology, the Journal of Medicinal Chemistry, PLOS Pathogens and several other journals.
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Contact: Kyeong-Ok Chang
kchang@k-state.edu
785-532-3849
Kansas State University
Source:Eurekalert

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