Navigation Links
Researchers develop synthetic compound that may lead to drugs to fight pancreatic, lung cancer
Date:3/9/2011

DALLAS March 10, 2011 Researchers at UT Southwestern Medical Center have identified a chemical compound that may eventually lead to a drug that fights cancers that are dependent on a particular anti-viral enzyme for growth.

The researchers are testing the compound's effectiveness at fighting tumors in mice. If it is successful, they will then work to develop a drug based on the compound to combat pancreatic and non-small cell lung cancer, two cancer types in which this particular enzyme, TBK-1, often is required for cancer cell survival.

"Our prediction is that TBK-1 is a good pharmacological intervention target for a subset of lung and pancreas cancers that are addicted to the activity of this enzyme. We believe there is a large population of cancer patients that could respond to inhibition of this activity," said Dr. Michael White, professor of cell biology and senior author of the study in the Feb. 18 issue of Molecular Cell.

The investigation, which lasted three and a half years, revealed how activation of the natural virus-fighting protein TBK-1 is hijacked in cancer cells to support growth and survival.

More than 250,000 compounds were screened to find one that would inhibit the enzyme's cancer-protection mechanism. The most effective, a compound called 6-aminopyrazolopyrimidine developed in collaboration with pharmaceutical company Amgen, blocked TBK-1's effects in 40 percent to 50 percent of the non-small cell lung cancer and pancreatic cancer tissue cultures tested, reducing cancer growth. TBK-1 is activated by the Ras family of oncogenes, which are mutated in 40 percent of lung cancers and 90 percent of pancreatic cancers.

"We found a biological activity that some cancer cells need to be able to survive, and we found a way to turn it off," said Dr. White.

The next step, he said, would be ascertaining in rodents whether 6-aminopyrazolopyrimidine can permeate tumors, "hit the target and be e
'/>"/>

Contact: Debbie Bolles
debbie.bolles@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Report: International collaboration between researchers results in greater recognition
2. U of M researchers using salmonella to fight cancer
3. University of South Florida researchers find blood-brain barrier damaged by disease
4. Boston researchers create SMArt platform architecture, launch $5,000 health app competition
5. UCLA researchers use nano-Velcro technology to improve capture of circulating cancer cells
6. Aging in place preserves seniors independence, reduces care costs, MU researchers find
7. Elderly see pedestrians half as often as younger drivers, according to Ben-Gurion U. researchers
8. Researchers use human cues to improve computer user-friendliness
9. Researchers find new mechanism behind the formation and maintenance of long-term memories
10. Researchers pinpoint genetic pathways involved in breast cancer
11. Penn researchers find new role for cancer protein p53
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... WA (PRWEB) September 20, 2014 “Motherhood is ... Center of Snohomish in their latest article , “We ... best that you can—and that’s what we want to do ... services they need and should expect from their Family Physicians ... following days of new motherhood. , To learn more ...
(Date:9/20/2014)... 2014 The children of Branches now ... active play they need. An empty lot at the ... Campus was transformed into a kid-designed playspace in less ... from Branches (@BranchesFL), ESPN (@TeamESPN), Disney (@CitizenDisney), area residents ... a playground is more than a playground. It’s a ...
(Date:9/19/2014)... (PRWEB) September 20, 2014 Consistent ... growth for the Vision Insurance industry in recent ... the detriment of industry margins. From 2009 to ... Industry operators provide coverage for routine eye exams ... for eyeglasses, contact lens and refractive surgery. According ...
(Date:9/19/2014)... September 19, 2014 Are you tired ... of problems with seasonal allergies or sinus congestion? Fortunately, ... better alternative. , She conceived of Nose Pal ... a runny nose in public. Since it prevents nasal ... more sanitary conditions, particularly when cooking or working closely ...
(Date:9/19/2014)... 2014 BearCom, a nationwide provider ... the key role played by instant, one-to-one and ... healthcare industry. , “In healthcare, speed of ... and in emergency situations, can save precious seconds ... death,” said Hugh Johnston, Product & Purchasing Manager ...
Breaking Medicine News(10 mins):Health News:Newest Article from Community Health Center of Snohomish County Highlights The Importance of Proper Health Care for Expectant Mothers 2Health News:Volunteers Improve Miami Kids’ Lives and Futures with Play 2Health News:Volunteers Improve Miami Kids’ Lives and Futures with Play 3Health News:Volunteers Improve Miami Kids’ Lives and Futures with Play 4Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 4Health News:Nasal Drip Eliminator Invented by InventHelp Client (LCC-218) 2Health News:BearCom Releases Guidelines on Using Two-Way Radios to Improve Communications and Enhance Patient Service in Healthcare 2Health News:BearCom Releases Guidelines on Using Two-Way Radios to Improve Communications and Enhance Patient Service in Healthcare 3Health News:BearCom Releases Guidelines on Using Two-Way Radios to Improve Communications and Enhance Patient Service in Healthcare 4
... has been reported that in the hospitals run by NHS ... contracting MRSA due to overcrowding//. According to the Daily Telegraph, ... the Government’s recommended level. ,Norman Lamb, the ... hospitals are crowded, it becomes an uphill task to keep ...
... the British Snoring and Sleep Apnoea Association (BSSAA) reveals that ... a detrimental effect on health and ruins sex lives. ... brought out an anti snore bedroom which has suspension beds ... aid people who suffer from dust and nasal congestion. ...
... autism disorders are best met by parents with knowledge and ... for Disease Control and Prevention now estimating that as many ... autism spectrum disorder, more parents than ever are facing concerns ... systems. ,Oliver Wendt, an assistant professor of educational studies ...
... The governing board of Medicine of Johns Hopkins today ... ban smoking// in all indoor public spaces in the ... regular meeting of the Johns Hopkins Medicine Board of ... commitment to the public health of the citizens of ...
... we think, but it is also more treatable than ... and adolescents should be monitored carefully because kidney disease ... its roots in childhood. ,Kidney disease develops silently ... it’s far too late to stop the progressive loss ...
... health risks posed by mercury contaminated fish are enormous ... to be careful about how much// and which fish ... today in a special issue of the international science ... Conference on Mercury as a Global Pollutant last August ...
Cached Medicine News:Health News:Parents Should Do Their Homework to Aid Autistic Child's Education 2Health News:Johns Hopkins Medicine Trustees Support Smoking Ban In Public Spaces 2Health News:Kidney Disease In Children: Common but Treatable 2Health News:Methylmercury in Marine Fish Pose Health Risks to Pregnant Women and Elderly Men 2Health News:Methylmercury in Marine Fish Pose Health Risks to Pregnant Women and Elderly Men 3
(Date:9/19/2014)... Harwood Feffer LLP ( www.hfesq.com ) is ... PDL BioPharma, Inc. ("PDL" or the "Company") (Nasdaq: ... its fiduciary duties to shareholders or violated the federal ... Company disclosed: "On September 11, 2014, [PDL] was orally ... Young LLP ("EY"), that it was resigning effective September ...
(Date:9/19/2014)... Sept. 19, 2014 /PRNewswire-iReach/ -- Market Research ... Industry, 2009-2019 is a professional and in-depth ... Hydrochloride industry. The report firstly reviews the ... classification, application and manufacturing technology. The report ... of Oxybutynin Hydrochloride listing their product specification, ...
(Date:9/19/2014)... , Sept. 19, 2014  The board of directors ... a quarterly cash dividend of $0.42 per share.  ... 2014 to stockholders of record at the close of ... AbbVie is a global, research-based biopharmaceutical company formed in ... to use its expertise, dedicated people and unique approach ...
Breaking Medicine Technology:Harwood Feffer LLP Announces Investigation of PDL BioPharma, Inc. 2Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 2Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 3Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 4Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 5
... Jan. 28, 2011 Awarepoint Corporation, a privately ... 2010 with 91 hospital sites contracted consisting of ... (RTLS) network coverage in U.S. hospitals and 135,265 ... largest enterprise-wide U.S. hospital client base for RTLS ...
... NATICK, Mass., Jan. 28, 2011 Boston Scientific Corporation ... afternoon, the Civil Division of the U.S. Department of ... against Boston Scientific, Guidant LLC and other entities.  This ... of PRIZM™ 2 and RENEWAL® implantable cardioverter defibrillators (ICDs). ...
Cached Medicine Technology:Awarepoint Announces RTLS in Healthcare Leadership with 2010 Results 2Awarepoint Announces RTLS in Healthcare Leadership with 2010 Results 3Awarepoint Announces RTLS in Healthcare Leadership with 2010 Results 4Boston Scientific Responds to DOJ Civil Lawsuit 2Boston Scientific Responds to DOJ Civil Lawsuit 3
Hunt tumor grasping forceps....
Micro 2000 suture forceps light-weight instruments with blue-colored anodized round handles, extremely light weight, well balanced, easy to handle, fatigueless working, easy to maintain, corrosion-re...
Micro dressing forceps....
Round tip, sharp all around, angled....
Medicine Products: