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Researchers develop non-invasive technique for predicting patients' response to chemotherapy
Date:11/7/2012

example, in a recent study, we have shown that the drug bevacizumab, which inhibits the creation of new blood vessels supplying the tumour, induces a rapid and significant reduction in delivery of [11C]docetaxel to tumours in non-small cell lung cancer patients," said Dr van der Veldt.

She concluded: "Although, at present, [11C]docetaxel PET cannot be used on a large scale because of its complexity and high costs, it is a promising technique for several investigations. [11C]docetaxel PET may be useful to predict response to docetaxel therapy and select patients for docetaxel-containing treatment strategies, thereby contributing to more personalised treatment planning in individual cancer patients. In addition, [11C]docetaxel PET may help to define the optimal design of large clinical trials to investigate the effects of drug scheduling on efficacy in cancer patients."

Professor Stefan Sleijfer, the scientific chair of the EORTC-NCI-AACR Symposium, from Erasmus University Medical Centre (The Netherlands), commented: "This study is interesting because it provides more insight into the amount of drug that reaches the place where it should go: the tumour cell. Because of technical limitations, this is a relatively unexplored field of research, which is of great importance. Eventually, this may lead to better prediction of outcome and novel combinations augmenting the penetration of active anti-tumour agents into the tumours."


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Contact: Emma Mason
wordmason@mac.com
ECCO-the European CanCer Organisation
Source:Eurekalert

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