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Researchers develop non-invasive technique for predicting patients' response to chemotherapy
Date:11/7/2012

m with this is the fact that the behaviour of [11C]docetaxel in the tumour at tracer doses may be different from its behaviour at therapeutic doses. Therefore, we investigated whether a PET study using tracer doses of [11C]docetaxel could predict tumour uptake of docetaxel at therapeutic doses."

Six lung cancer patients who had not been treated previously with docetaxel underwent two PET scans, one with the tracer dose of docetaxel, and another during a combined infusion of a tracer dose and a therapeutic dose (75mg/m2) of docetaxel. The researchers compared the tumour uptake of both the tracer and therapeutic doses of docetaxel and found that the tracer dose correctly predicted the tumour uptake of the therapeutic dose.

"This study showed that microdosing data from PET scans of [11C]docetaxel could be used to reliably predict tumour uptake of docetaxel during chemotherapy, which was also associated with tumour response to docetaxel therapy. This is important information for us to have when we are treating patients, as it helps us to predict how well the drug is working and whether it might be better to switch to some other, potentially more effective treatment. The findings of this study warrant larger clinical studies investigating the predictive value of initial [11C]docetaxel uptake for tumour response to docetaxel therapy," said Dr van der Veldt. "In addition, the present study provides a framework for investigating the PET microdosing concept for other radiolabeled anti-cancer drugs in patients with other cancers.

"To the best of our knowledge, the present study is the first in which absolute tumour uptake of chemotherapy is measured non-invasively in patients."

Additional analyses revealed that less than one per cent of the therapeutic dose of docetaxel that was infused in the patients was finally taken up by the tumour tissue. This uptake might also be affected by other drugs that are being delivered at the same time. "For
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Contact: Emma Mason
wordmason@mac.com
ECCO-the European CanCer Organisation
Source:Eurekalert

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