Navigation Links
Researchers develop non-invasive technique for predicting patients' response to chemotherapy
Date:11/7/2012

m with this is the fact that the behaviour of [11C]docetaxel in the tumour at tracer doses may be different from its behaviour at therapeutic doses. Therefore, we investigated whether a PET study using tracer doses of [11C]docetaxel could predict tumour uptake of docetaxel at therapeutic doses."

Six lung cancer patients who had not been treated previously with docetaxel underwent two PET scans, one with the tracer dose of docetaxel, and another during a combined infusion of a tracer dose and a therapeutic dose (75mg/m2) of docetaxel. The researchers compared the tumour uptake of both the tracer and therapeutic doses of docetaxel and found that the tracer dose correctly predicted the tumour uptake of the therapeutic dose.

"This study showed that microdosing data from PET scans of [11C]docetaxel could be used to reliably predict tumour uptake of docetaxel during chemotherapy, which was also associated with tumour response to docetaxel therapy. This is important information for us to have when we are treating patients, as it helps us to predict how well the drug is working and whether it might be better to switch to some other, potentially more effective treatment. The findings of this study warrant larger clinical studies investigating the predictive value of initial [11C]docetaxel uptake for tumour response to docetaxel therapy," said Dr van der Veldt. "In addition, the present study provides a framework for investigating the PET microdosing concept for other radiolabeled anti-cancer drugs in patients with other cancers.

"To the best of our knowledge, the present study is the first in which absolute tumour uptake of chemotherapy is measured non-invasively in patients."

Additional analyses revealed that less than one per cent of the therapeutic dose of docetaxel that was infused in the patients was finally taken up by the tumour tissue. This uptake might also be affected by other drugs that are being delivered at the same time. "For
'/>"/>

Contact: Emma Mason
wordmason@mac.com
ECCO-the European CanCer Organisation
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... 11, 2014 The International Concussion ... at the Best Buy Theater in Times Square, ... to the growing concussion epidemic that is plaguing ... levels of competition. , The Symposium gathers more ... researchers, coaches, professional athletes and legal scholars for ...
(Date:7/11/2014)... Newport Beach, CA (PRWEB) July 11, 2014 ... product pure Artichoke Leaf Extract dietary supplements to aid ... flow, an action necessary to facilitate metabolism of fat. ... facilities, Superior Labs Artichoke Leaf Extract is available in ... of pure artichoke extract. , Health Benefits of ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 ... begin this August in New York. ... cover: , -Myofascial Trigger Point Therapy, ... -Mobilization & Thrust Manipulation, -Neuroobilization & Neurodynamics, ... prescribing to a single, isolated manual therapy ...
(Date:7/11/2014)... TX (PRWEB) July 11, 2014 Plasma ... of blood products industry. Although the closure of 16 ... major disruption to domestic blood products market, the total ... 2.8% year on year and total lot release volume ... due to stock consumption, insufficient utilization of new plasma ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 This morning(July 9th, ... 13--Good Morning Memphis to discuss the illegal immigration crisis at ... town of McAllen, Texas. , Dr. Flinn told Good Morning ... is absolutely wide open… The problem is that they do ... Thousands of people per day are coming into the border; ...
Breaking Medicine News(10 mins):Health News:The International Concussion Organization 501(c)(3) hosts its 1st Annual Concussion Symposium at the Best Buy Theater in Time Square, NYC, July 17th, 2014. 2Health News:Artichoke Leaf Extract Released by SuperiorLabs Now Available on Amazon.com With 2 Day Prime Shipping 2Health News:Artichoke Leaf Extract Released by SuperiorLabs Now Available on Amazon.com With 2 Day Prime Shipping 3Health News:Hands-On Seminars, the Leader in Manual Therapy Continuing Education, Announces Series of Comprehensive Hands-On Training Courses 2Health News:Chinese Blood Product Industry Report 2014-2017 Focuses Plasma Volume & Stations Says A New Research Available at ChinaMarketResearchReports.com 2Health News:Chinese Blood Product Industry Report 2014-2017 Focuses Plasma Volume & Stations Says A New Research Available at ChinaMarketResearchReports.com 3Health News:Chinese Blood Product Industry Report 2014-2017 Focuses Plasma Volume & Stations Says A New Research Available at ChinaMarketResearchReports.com 4Health News:Senate Candidate, George Flinn on Fox13 NEWS About the Border Crisis 2
... developed deposits, study finds , , WEDNESDAY, Feb. 4 (HealthDay ... sickened more than 50,000 kids last fall resulted in ... developing kidney problems, according to just-released Beijing research on ... in Taiwan and 10 percent of those who drank ...
... (AUA) will hold its Annual Scientific Meeting in Chicago, ... Meeting is the largest meeting of urologic professionals in ... urologists and healthcare professionals from around the world. This ... more than 300 exhibitors will showcase their products and ...
... Pharmacies will host an in-store Healthy Heart Event., ... well as provide information to help patients better ... Pharmacists will also help patients, ... blood pressure and heart disease., WHY: ...
... /PRNewswire-FirstCall/ -- Bionovo, Inc. (Nasdaq: ... will be presenting at the National Cancer Institute,s Office ... series. The title of the presentation is "Selective Cytotoxic ... Effects in Patients with Advanced Breast Cancer," and will ...
... provider of complete solutions for the analysis of Next ... Molecular Biology Laboratory (EMBL) installed a Genomatix Mining Station ... Facility. These systems deliver the only complete and integrated ... generated by the sequencer, to a molecular level understanding ...
... is seeking nominations for the Fourth Annual Bioscience Awards ... interested in nominating a company or individual for an ... are: Entrepreneurial, Best New Product or Progress, Leadership in ... submit documentation and narratives that fulfill several criteria and ...
Cached Medicine News:Health News:Tainted China Formula Caused High Rate of Kidney Stones in Kids 2Health News:Tainted China Formula Caused High Rate of Kidney Stones in Kids 3Health News:Bionovo Announces Presentation at the National Cancer Institute 2Health News:Bionovo Announces Presentation at the National Cancer Institute 3Health News:EMBL GeneCore purchases Genomatix's next generation sequencing data analysis solution 2Health News:EMBL GeneCore purchases Genomatix's next generation sequencing data analysis solution 3Health News:GBC Seeks Nominations for Fourth Annual Bioscience Awards 2
(Date:7/10/2014)... , July 11, 2014  Major advances in ... cancer are being highlighted in a three-day Oncology ... from 10-12 July, 2014.  Renowned national and international cancer ... best practices and exchange knowledge on modern technologies ... and efficient. The Summit will ...
(Date:7/10/2014)... Virginia , 11. Juli 2014 ... von Kameras für die molekulare Bildgebung, ... hat heute die CE-Zulassung für sein ... CE-Zeichen kann Dilon das Produkt jetzt ... auf den Großteil der europäischen Länder ...
(Date:7/10/2014)... July 10, 2014  The U.S. Department of Health ... to University Hospitals (UH) Case Medical Center Seidman Cancer ... model aimed at improving care for patients with complex ... project will test a unique model developed at UH ... disease, significant comorbidities, or demonstrated need for high health ...
Breaking Medicine Technology:Improving quality and access to advanced cancer care in India and South Asia 2Improving quality and access to advanced cancer care in India and South Asia 3Improving quality and access to advanced cancer care in India and South Asia 4Improving quality and access to advanced cancer care in India and South Asia 5Dilon erhält CE-Zulassung für sein Navigator-Gamma-Sondensystem 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 3University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 4
... /PRNewswire/ -- Treatment of,coronary artery disease (CAD) appears to ... study published today in The,American Journal of Cardiology. , ... 10.6 percent from 2002 to 2005, possibly due,to broader ... as well as declines in risk factors like smoking. ...
... Research from Non-clinical Studies Presented at the ... Symposia Molecular,Targets for Cancer Meetings Support Phase ... March 20, 2007,/PRNewswire-FirstCall/ -- Sunesis Pharmaceuticals, Inc. ... SNS-314, at,two leading scientific meetings focused on ...
Cached Medicine Technology:Hospitalization Rates for Coronary Artery Disease Decline in the,U.S. 2Hospitalization Rates for Coronary Artery Disease Decline in the,U.S. 3Sunesis Pharmaceuticals Presents SNS-314 Aurora Kinase Inhibitor,Data Showing Broad Anti-Tumor Activity, Dosing Flexibility 2Sunesis Pharmaceuticals Presents SNS-314 Aurora Kinase Inhibitor,Data Showing Broad Anti-Tumor Activity, Dosing Flexibility 3
Series I Small Joint Arthroscopy Hand Instruments feature small yet durable instruments specifically designed for small joint arthroscopy. They are available in a variety of low profile styles: strai...
Series I Small Joint Arthroscopy Hand Instruments feature small yet durable instruments specifically designed for small joint arthroscopy. They are available in a variety of low profile styles: strai...
Series I Small Joint Arthroscopy Hand Instruments feature small yet durable instruments specifically designed for small joint arthroscopy. They are available in a variety of low profile styles: strai...
Series I Small Joint Arthroscopy Hand Instruments feature small yet durable instruments specifically designed for small joint arthroscopy. They are available in a variety of low profile styles: strai...
Medicine Products: