Navigation Links
Researchers develop non-invasive technique for predicting patients' response to chemotherapy
Date:11/7/2012

Researchers have developed a non-invasive way of predicting how much of a cancer-killing drug is absorbed by a tumour. The preliminary study, which will be reported at the 24th EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics in Dublin, Ireland, today (Thursday), was conducted in lung cancer patients and it also revealed that less than one per cent of the drug, docetaxel, is absorbed by the tumours [2].

Dr Astrid van der Veldt (MD, PhD), from the VU University Medical Center in Amsterdam, The Netherlands, told the Symposium: "This finding underscores the fact that only a small amount of drug accumulates in tumours and indicates that there is an urgent need for strategies that selectively enhance drug delivery to tumours. For that purpose, the direct effects of other, anti-cancer drugs on metabolism as well as drug delivery to tumours need to be investigated, as other drugs may also affect metabolism and drug delivery to tumours."

Until now, there has been no accurate way of assessing how much of an anti-cancer drug is absorbed by a tumour and, therefore, what effect the drug is having on the tumour, without invasive surgery to extract samples.

Dr van der Veldt and her colleagues used an imaging technique called positron emission tomography (PET) to track very small tracer doses of the anti-cancer drug docetaxel, which had been radiolabeled with the positron emitting radionuclide carbon-11, in the patient. The PET scan was able to follow this tiny [11C]docetaxel dose in the body non-invasively and provide information on how much reached the tumour, the amount absorbed by the tumour and its effect on the tumour (the pharmacokinetics and pharmacodynamics of the drug). By using a microdose of docetaxel in this way, the patients were protected from any docetaxel-induced toxic side-effects that could occur if the docetaxel was administered at therapeutic doses.

Dr van der Veldt said: "A potential problem with this is the fact that the behaviour of [11C]docetaxel in the tumour at tracer doses may be different from its behaviour at therapeutic doses. Therefore, we investigated whether a PET study using tracer doses of [11C]docetaxel could predict tumour uptake of docetaxel at therapeutic doses."

Six lung cancer patients who had not been treated previously with docetaxel underwent two PET scans, one with the tracer dose of docetaxel, and another during a combined infusion of a tracer dose and a therapeutic dose (75mg/m2) of docetaxel. The researchers compared the tumour uptake of both the tracer and therapeutic doses of docetaxel and found that the tracer dose correctly predicted the tumour uptake of the therapeutic dose.

"This study showed that microdosing data from PET scans of [11C]docetaxel could be used to reliably predict tumour uptake of docetaxel during chemotherapy, which was also associated with tumour response to docetaxel therapy. This is important information for us to have when we are treating patients, as it helps us to predict how well the drug is working and whether it might be better to switch to some other, potentially more effective treatment. The findings of this study warrant larger clinical studies investigating the predictive value of initial [11C]docetaxel uptake for tumour response to docetaxel therapy," said Dr van der Veldt. "In addition, the present study provides a framework for investigating the PET microdosing concept for other radiolabeled anti-cancer drugs in patients with other cancers.

"To the best of our knowledge, the present study is the first in which absolute tumour uptake of chemotherapy is measured non-invasively in patients."

Additional analyses revealed that less than one per cent of the therapeutic dose of docetaxel that was infused in the patients was finally taken up by the tumour tissue. This uptake might also be affected by other drugs that are being delivered at the same time. "For example, in a recent study, we have shown that the drug bevacizumab, which inhibits the creation of new blood vessels supplying the tumour, induces a rapid and significant reduction in delivery of [11C]docetaxel to tumours in non-small cell lung cancer patients," said Dr van der Veldt.

She concluded: "Although, at present, [11C]docetaxel PET cannot be used on a large scale because of its complexity and high costs, it is a promising technique for several investigations. [11C]docetaxel PET may be useful to predict response to docetaxel therapy and select patients for docetaxel-containing treatment strategies, thereby contributing to more personalised treatment planning in individual cancer patients. In addition, [11C]docetaxel PET may help to define the optimal design of large clinical trials to investigate the effects of drug scheduling on efficacy in cancer patients."

Professor Stefan Sleijfer, the scientific chair of the EORTC-NCI-AACR Symposium, from Erasmus University Medical Centre (The Netherlands), commented: "This study is interesting because it provides more insight into the amount of drug that reaches the place where it should go: the tumour cell. Because of technical limitations, this is a relatively unexplored field of research, which is of great importance. Eventually, this may lead to better prediction of outcome and novel combinations augmenting the penetration of active anti-tumour agents into the tumours."


'/>"/>
Contact: Emma Mason
wordmason@mac.com
ECCO-the European CanCer Organisation
Source:Eurekalert

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/7/2016)... Texas (PRWEB) , ... February 07, 2016 , ... ... new MyDecision™ program. MyDecision™ empowers employers and organizations with the tools and information ... MyDecision™ combines three elements to cut the cost of providing employee healthcare benefits ...
(Date:2/6/2016)... ... February 06, 2016 , ... ... ADVISORY: 5000 PERIOPERATIVE NURSES EXPECTED AT AORN SURGICAL CONFERENCE & EXPO , ... the world with an estimated 5000 perioperative nurses in attendance to study ...
(Date:2/6/2016)... ... ... With the FCPX LUT: Summer pack from Pixel Film Studios, ... is a Lookup Table that contains a mathematical formula for modifying an image. The ... manipulating each pixel, LUT's can change each color range differently, it gives the user ...
(Date:2/6/2016)... , ... February 06, 2016 , ... ... of eating disorder treatment helps to reduce the frequency and level of relapse. ... Recovery Phase: Re-Establishing Healthy Identity and Purpose,” will explore the critical tasks of ...
(Date:2/5/2016)... ... February 05, 2016 , ... Love is in the air ... variety of colors, assortments and packaging. This staple for Valentine’s Day is a must-have, ... , For Valentine’s Day, not only are long-stem roses available, but also other ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... 4, 2016  Omnicell, Inc. (NASDAQ: OMCL ), a ... healthcare systems, today announced results for its fiscal year ... --> --> GAAP results: Revenue for ... $5.1 million or 4.1% from the third quarter of ... fourth quarter of 2014. Revenue for the year ended ...
(Date:2/4/2016)... 2016  Aethlon Medical, Inc. (Nasdaq: AEMD ... to treat life-threatening diseases, today announced results for ... 31, 2015. --> ... in our last quarterly call, we strategically advanced ... objective to establish the Aethlon Hemopurifier® as a ...
(Date:2/4/2016)... 4, 2016  AMRI (NASDAQ:  AMRI) today announced that ... and President of Pfizer Global Supply, has been elected to ... 2016. In addition, the Company announced that Mr. Gabe ... since 2010, has retired from the AMRI Board of Directors ... other business ventures.  William S. Marth , ...
Breaking Medicine Technology: