Navigation Links
Researchers develop new way to predict heart transplant survival

Johns Hopkins researchers say they have developed a formula to predict which heart transplant patients are at greatest risk of death in the year following their surgeries, information that could help medical teams figure out who would benefit most from the small number of available organs.

"Donor hearts are a limited resource," says John V. Conte, M.D., a professor of surgery at the Johns Hopkins University School of Medicine and the senior author of the study. "Now, we have a simple-to-use tool that is highly predictive of survival after a heart transplant, and can help guide organ allocation decisions."

Conte and his colleagues, writing in the September issue of Annals of Thoracic Surgery, pulled together a series of risk factors already associated with poor outcomes, such as age, race, gender, the cause of a patient's heart failure and whether he or she was on dialysis, and then assigned a number of points to each factor. The sum of those points created a score. The higher the score, the higher the risk of death one year after transplant.

Some factors were weighted more heavily than others, such as female gender (three points); African-American race (three points), and the need for dialysis in the time between being put on the transplant waiting list and getting a transplant (five points).

Patients with the lowest scores between zero and two had a 92.5 percent chance of being alive 12 months after surgery.

Patients with so-called IMPACT scores the acronym the researchers came up with for the Index for Mortality Prediction After Cardiac Transplantation above 20 points had a less than 50 percent chance of survival one year after surgery. Every point on the scale increased the chance of death within one year by 14 percent.

To develop and test the validity of IMPACT, Conte and his team analyzed data provided by the United Network of Organ Sharing comprising information from all heart transplants 21,378 of them conducted in the United States between 1987 and 2010.

More research is needed to learn what role is played by factors other than the recipient's risks, Conte says. Resuslts of their study suggest, for example, that an organ coming from a donor over the age of 50 or one that has been outside the body for more than four hours also increases the risk of death in the recipient, he says.

More than 3,000 people are on the waiting list for a heart transplant in the United States, and many will die before they can get a new heart. Only about 2,000 heart transplants are performed in the U.S. annually. Currently, determining who gets an available heart takes into account how long a patient has been on the list and how sick they are. There is no standardized consideration of other factors that may predict patients' outcomes, as is the case in determining which patients receive available lungs for transplant. Incorporating the IMPACT score would add another dimension to the conversation about who gets a heart transplant, says Conte, surgical director of heart transplantation at Johns Hopkins.

"As clinicians, we make an educated risk of what the risk is going to be," he says. "This tool provides a quantitative way to assess the risk."


Contact: Stephanie Desmon
Johns Hopkins Medical Institutions

Related medicine news :

1. Researchers investigate new mechanism for predicting how diseases spread
2. Researchers successfully perform first injection of cultured red blood cells in human donor
3. Researchers share discoveries about aging-related changes in health and cognition
4. UC Davis researchers develop computer model for testing heart-disease drugs
5. Stanford researchers invent sutureless method for joining blood vessels
6. Yale researchers use genetic code to engineer a living protein
7. Researchers developing new test to measure risk for birth defects and neuro-developmental disorders
8. Breast-Feeding Wont Prevent Kids Eczema, Researchers Say
9. Government subsidies to the US film industry promote youth smoking, argue researchers
10. Researchers Say Theyve Found Common Cause of All Types of ALS
11. UCSD researchers alarmed at rise in hookah use among California youth
Post Your Comments:
(Date:11/25/2015)... ... ... Smiles by Stevens is pleased to announce the addition of ... patients are aware of the benefits of Botox® in the treatment of moderate facial ... discomfort, soreness, and pain as a result of Jaw Tension, TMJ (temporo-mandibular joint) disorder, ...
(Date:11/25/2015)... ... November 25, 2015 , ... Beddit® has launched a ... sleep tracking systems. The new app features a more intuitive SleepScore™ that rates sleep ... well you slept. The SleepScore is created by a proprietary algorithm. Beddit analyzes the ...
(Date:11/25/2015)... MI (PRWEB) , ... November 25, 2015 , ... In ... Presence Resurrection Medical Center (RMC) in Chicago, IL, UV Angel is evaluating the efficacy ... medical and surgical intensive care units (totaling 30 beds) from May 2014 through October ...
(Date:11/25/2015)... ... , ... Today, Mothers Against Drunk Driving (MADD) learned that the ... the first time since 2011. In 2014, there were 9,967 fatalities involving an alcohol ... National Highway Traffic Safety Administration (NHTSA), 32,675 people were killed in traffic crashes in ...
(Date:11/25/2015)... Spring, Md (PRWEB) , ... November 25, 2015 ... ... Pulmonary Hypertension Association (PHA) announces the nation’s Periwinkle Pioneers, individuals and groups responsible ... history of this disease. The Periwinkle Pioneers, nominated by the public, will receive ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... -- Henry Schein, Inc., the world,s largest provider of health ... animal health practitioners, will unveil at the Greater New ... Pavilion , which brings together for the first time ... help any practice or laboratory enter the digital age. ... of experts appearing at the Pavilion. --> ...
(Date:11/25/2015)... -- Allergan plc (NYSE: AGN ), a ... start-up  biotechnology company focused on the development of ... by the F-Prime Biomedical Research Initiative (FBRI), today ... collaboration to support the discovery and development of ... Obsessive Compulsive disorders (OCD). ...
(Date:11/25/2015)... , Nov. 25, 2015 /PRNewswire/ ... "Company") (NYSE: MR ), a ... medical devices worldwide, today announced that ... general meeting of shareholders at the ... Grand Century, 193 Prince Edward West Road, ...
Breaking Medicine Technology: