Navigation Links
Researchers develop new method to test for lung cancer
Date:4/1/2008

Boston, MA--Researchers from Boston University School of Medicine have developed a new clinicogenomic model to accurately test for lung cancer. The model combines a specific gene expression for lung cancer as well as clinical risk factors. These findings currently appear on-line in the journal Cancer Prevention Research.

Lung cancer is the leading cause of cancer death in the United States and the world, with more than one million deaths worldwide annually. Eighty-five to 90 percent of subjects with lung cancer in the United States are current or former smokers with 10 to 20 percent of heavy smokers developing this disease.

A previous study by the same researchers reported a gene expression biomarker capable of distinguishing cytologically normal large airway epithelial cells from smokers with and without lung cancer. However, the biomarker has limited sensitivity depending on the stage and the location of the cancer.

Studying current and former smokers undergoing bronchoscopies for suspicion of lung cancer, the researchers compared the likelihood of the subjects having lung cancer using the biomarker, the clinical risk factors and a combination of the two -- clinicogenomic model. They found patients using the clinicogenomic model had increased sensitivity, specificity, positive value and negative predictive value of their cancer compared to the other methods.

Our data suggests that the clinicogenomic model might serve to identify patients who would benefit from further invasive testing, thereby expediting the diagnosis and treatment for their malignancy, said senior author Avrum Spira, MD, an assistant professor of medicine and pathology at Boston University School of Medicine.

According to the researchers, it is hoped this prediction model will expedite more invasive testing and appropriate therapies for smokers with lung cancer as well as reduce invasive diagnostic procedures for individuals without lung cancer.


'/>"/>

Contact: Allison Rubin
allison.rubin@bmc.org
617-638-8491
Boston University
Source:Eurekalert

Related medicine news :

1. UCLA researchers design nanomachine that kills cancer cells
2. Researchers study why high school boys dodge Phys Ed
3. Researchers Successfully Test Ebola Vaccines
4. Researchers identify a gene responsible for cases of Lou Gehrigs disease
5. Researchers identify a gene responsible for Lou Gehrigs disease
6. UCLA researchers examine human embryonic stem cell genome
7. Researchers Create Protective Sac for Growing Stem Cells
8. UC Irvine researchers present latest findings at emergency medicine forum
9. Researchers urge ethics guidelines for human-genome research
10. OHSU Cancer Institute researchers identify new approach to help control drug resistance in leukemia
11. NYU dental researchers find evidence of periodontal disease leading to gestational diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... , ... MD Now Urgent Care opened its newest location on ... marks the urgent care center's eighth location in Miami-Dade county. , The center's address ... The new clinic offers a wide array of services to patients in ...
(Date:6/23/2017)... ... June 23, 2017 , ... Ross Insurance ... With the Federal Emergency Management Agency’s (FEMA) recent update of flood zones, more ... 2012, the Biggert-Waters Act was enacted to reflect the actual risk in flood ...
(Date:6/23/2017)... ... ... Ulster University, Magee Campus in Northern Ireland is hosting The Schools for ... to graduate students exciting new and innovative hope research based on iFred’s “Schools for ... Improvement Service of the Western Health & Social Care Trust (WHSCT) in partnership with ...
(Date:6/23/2017)... ... 23, 2017 , ... Jusino Insurance Services, a locally owned ... greater Chicago metropolitan area, is embarking on a charity drive in conjunction with ... Founded in 1897, Hephzibah Children’s Association is one of the oldest social services ...
(Date:6/23/2017)... ... June 23, 2017 , ... Radabaugh ... planning to families and business owners in North Central West Virginia, is embarking ... services to differently abled residents in the region. , The Stepping Stones organization ...
Breaking Medicine News(10 mins):
(Date:6/13/2017)... June 13, 2017 Zimmer Biomet Holdings, Inc. (NYSE ... announced that the U.S. Food and Drug Administration (FDA) has ... 2015 relating to its Zhejiang, China ... "The successful clearance of the Warning Letter related ... facility is a measure of the progress we have made ...
(Date:6/10/2017)... June 9, 2017  Shane K. Burchfield, DPM, is recognized by ... as a Podiatrist in Alabama . ... First Foot Care. He brings over 20 years of experience, as ... and healthcare, to his role. ... PC is pleased to welcome you to his practice," ...
(Date:6/8/2017)... , June 8, 2017  Less than a ... hit more than 200,000 companies, including hospital networks, in ... heralded as one of the largest online extortion attempts ... the healthcare market, it is imperative that providers understand ... their data from this — and many other very ...
Breaking Medicine Technology: