Navigation Links
Researchers develop long-lasting growth hormone
Date:9/4/2007

Researchers at the University of Sheffield have developed a long-acting growth hormone for use in human therapy. The new discovery could mean that children and adults with growth hormone disorders will not have to have injections as often, reducing the need for daily treatments.

Most hormones and cytokines have a short life and therefore require frequent injections as therapy. However, the new technology developed by the multidisciplinary team at Sheffield, means that scientists and clinicians are able to generate effective, long-acting hormones which promote growth over a minimum of ten days, after just one injection.

The research, published in the prestigious journal Nature Medicine, shows that the hormones are able to act for longer because of unique characteristics in the new molecules created in Sheffield.

Hormones normally circulate in blood attached to binding proteins that prevent their clearance from the circulation and prolong their biological action. The new molecules created by the scientists, however, are able to bind to each other in a head-to-tail configuration, doubling their molecular mass in the bloodstream. This delays their absorption and elimination from the blood and therefore generates a hormone that will last for a longer period of time.

Professor Richard Ross, from the Universitys School of Medicine and Biomedical Sciences, said: "We are very excited by these results and believe this technology will bring significant benefit to patients. Children and adults with growth hormone deficiency have to give themselves daily injections and it is hoped that the new technology will reduce the number of times they have to do this to once every two weeks, or even once a month."

Professor Peter Artymiuk, a structural biologist in the Universitys Department of Molecular Biology and Biotechnology, added: "Although we are only in the early stages of the drug development process, and any drugs resulting from this research are several years away from approval, its wonderful to see the science translate from the computer screen to what we hope will be real benefits for patients."

Professor Jon Sayers, from the Universitys School of Medicine and Biomedical Sciences, commented: "We believe that the technology can also be applied to treat inflammatory diseases such as multiple-sclerosis, cancer and metabolic diseases."


'/>"/>

Contact: Lindsey Bird
l.bird@sheffield.ac.uk
01-142-225-338
University of Sheffield
Source:Eurekalert

Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Ecstasy shrinks brain!!-researchers unveil the secrets of MDMA.
4. New Hair in 15 Days Could Now Be A Possibility Say Researchers
5. Researchers at Cornell University as been reported using research fund by false claims
6. Researchers trick Alzheimers Enzyme
7. Researchers find new HIV hiding place
8. Gene researchers make Malaria-resistant mosquito
9. Researchers developed world’s smallest toothbrus
10. Researchers discover receptor cells that can cause epilepsy
11. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... established the certification process to promote standards of excellence for the field of ... scheduled for March 22 – 25, 2018 in Orlando, Florida at the Omni ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Many families ... However, many long-term care insurance companies have a waiver for care if the client ... elimination period, when the family pays for care, is often waived, so the benefits ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob ... sciatica in a new episode of "Success Files," which is an award-winning educational ... and investigates each subject in-depth with passion and integrity. , Sciatica occurs when ...
(Date:10/12/2017)... CA (PRWEB) , ... October 12, 2017 , ... ... Cheng, are now treating sleep apnea using cutting-edge Oventus O2Vent technology. ... a serious sleep disorder characterized by frequent cessation in breathing. Oral appliances can ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally recognized ... have expanded their existing home health joint venture through an agreement, effective October ... a joint venture home health company with Asante, delivering clinically integrated care, for ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... Pa. , Oct. 12, 2017 ... leader in innovative solutions for injectable drug administration, today ... before the market opens on Thursday, October 26, 2017, ... the results and business expectations at 9:00 a.m. Eastern ... (U.S.) or 253-336-8738 (International). The conference ID is 94093362. ...
(Date:10/11/2017)... , Oct. 11, 2017  True Health, a ... amplified its effort during National Breast Cancer Awareness ... cancer risks. ... Oncology calculated that more than 10 million American ... mutations in BRCA1 or BRCA2 and have not had ...
(Date:10/10/2017)... Oct. 10, 2017   West Pharmaceutical Services, Inc. ... for injectable drug administration, today shared the results of ... for improving the intradermal administration of polio vaccines. The ... Summit in May 2017 by Dr. Ondrej Mach ... World Health Organization (WHO), and recently published in the ...
Breaking Medicine Technology: