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Researchers develop device that simulates gastro-intestinal tract
Date:3/31/2014

colleagues developed a laboratory device that simulates the human gut and its differing pH gradients, which play a decisive role in determining the manner, in which orally-administered medications are dissolved and then absorbed. It is now possible to fairly discriminate the formulations of a new drug and identify potential candidates for further development that are likely to be successful during clinical trials.

"By minimising human trials we would reduce the cost of development, which is then charged to patients when the drug comes to the market if the development costs are lower, then we can make new drugs more affordable," said Dr Merchant, who has research experience in industry as well as academia.

The testing device, co-developed by Dr Merchant, includes a chamber for holding a solvent medium plus a pH probe and a control unit. This monitors changes in the pH of the solvent medium in order to test the performance of a drug carrier at different levels of acidity or alkalinity, mimicking the conditions of the gastrointestinal tract. The device is particularly suitable for testing and developing dosage forms for oral delivery of drugs and can also simulate the variability between individuals.


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Contact: Nicola Werritt
nicola.werritt@hud.ac.uk
01-484-473-315
University of Huddersfield
Source:Eurekalert  

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