Navigation Links
Researchers develop and test new molecule as a delivery vehicle to image and kill brain tumors
Date:8/3/2011

RICHMOND, Va. (Aug. 3, 2011) A single compound with dual function the ability to deliver a diagnostic and therapeutic agent may one day be used to enhance the diagnosis, imaging and treatment of brain tumors, according to findings from Virginia Commonwealth University and Virginia Tech.

Glioblastomas are the most common and aggressive brain tumor in humans, with a high rate of relapse. These tumor cells often extend beyond the well-defined tumor margins making it extremely difficult for clinicians and radiologists to visualize with current imaging techniques. Researchers have been investigating enhanced methods of attacking these cells in order to possibly delay or prevent brain tumor relapse.

In a study published in the August issue of the journal Radiology, the research team led by Panos Fatouros, Ph.D., a former professor and chair of the Division of Radiation Physics and Biology in the VCU School of Medicine who retired in 2010, demonstrated that a nanoparticle containing an MRI diagnostic agent can effectively be imaged within the brain tumor and provide radiation therapy in an animal model.

The nanoparticle filled with gadolinium, a sensitive MRI contrast agent for imaging, and coupled with radioactive lutetium 177 to deliver brachytherapy, is known as a theranostic agent a single compound capable of delivering simultaneously effective treatment and imaging. The lutetium 177 is attached to the outside of the carbon cage of the nanoparticle.

"We believe the clustering properties of this nanoplatform prolong its retention within the tumor, thereby allowing a higher radiation dose to be delivered locally," said Michael Shultz, Ph.D., a research fellow in Fatouros' lab in the Department of Radiology in the VCU School of Medicine.

"This theranostic agent could potentially provide critical data about tumor response to therapy by means of longitudinal imaging without further contrast administration," said Fatouros.

A nanoparticle called a functionalized metallofullerene (fMF), also known as a "buckyball," served as the basis of this work and was created by study collaborator, Harry Dorn, Ph.D., a chemistry professor at Virginia Tech, and his team. In 1999, Dorn and his colleagues were able to encapsulate rare earth metals in the hollow interior of these nanoparticles that can easily be recognized by MRI techniques.

"Although this is a limited animal study, it shows great promise and hopefully this metallofullerene platform will be extended to humans," said Dorn.


'/>"/>

Contact: Sathya Abraham
sbachia@vcu.edu
804-827-0890
Virginia Commonwealth University
Source:Eurekalert

Related medicine news :

1. Stomach Cancer Tumors Have Genetic Differences: Researchers
2. Traumatic brain injury: NIH-funded researchers will assess biomarkers for diagnosis and treatment
3. Researchers map minority microbes in the colon
4. Clemson University researchers are making every bite count
5. Researchers discover method to decrease harmful cyanogens and increase protein levels in key crop
6. Obesity counseling should focus on neurobehavioral processes, not personal choice, researchers say
7. Johns Hopkins researchers discover how some breast cancers alter their sensitivity to estrogen
8. Researchers aim for direct brain control of prosthetic arms
9. Researchers work to take the pressure off newborns lungs
10. Researchers capture breakthrough data on cervical spine injuries
11. To help doctors and patients, UB researchers are developing a vocabulary of pain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... ... ... Pastor and Overseer at The House of Yahweh in Abilene, Texas, has released a new ... the mother of the Savior whom the world calls “Mother Mary”. Yisrayl says when compared ... of this historical woman. , “The world bows, kisses the feet of, cries out ...
(Date:8/18/2017)... CARMEL, IN (PRWEB) , ... August 18, 2017 , ... ... 36th annual list, the most prestigious ranking of the nation's fastest-growing private companies. This ... in the exclusive Inc. 5000 ranking . This year’s ranking reflects ASH’s 76 ...
(Date:8/18/2017)... ... 18, 2017 , ... “Our Mountains to Climb: A Journey of Love and ... stronger together through the faith they shared to overcome struggles in life. “Our Mountains ... published author, Barbara J. Corcoran, a retired teacher and happily married since 1999; the ...
(Date:8/18/2017)... ... ... “Three Narrow Roads”: a vivid and provocative look into the narrow path toward ... Sr., is currently the pastor-teacher-visionary at Simply the WORD Church, a global prayer ministry ... program geared towards youth. , King shares, “When I take time to think about ...
(Date:8/18/2017)... ... August 18, 2017 , ... “Depressed: Super Heroes of the Bible”: ... reflect upon the stories and the relevance these tales may have on the reader’s ... Linhart, a former special education teacher, Jessica spends much of her time enjoying nature ...
Breaking Medicine News(10 mins):
(Date:7/31/2017)... July 31, 2017 7D Surgical, developer of ground ... purchased the 7D Surgical System to support its strategic sales ... D.C. and Virginia.  7D Surgical has entered into ... of the premier medical facilities within those markets. ... ...
(Date:7/28/2017)... --EnvoyHealth, a Diplomat company, has partnered with Compliance Meds ... a technology designed to improve patient medication adherence. ... solutions and services that help track and improve patients, ... LITE offers medication monitoring and control for patients and ... Records date and time of bottle ...
(Date:7/27/2017)... Pa., July 27, 2017  West Pharmaceutical Services, Inc. ... results for the second-quarter 2017 and updated financial guidance ... Second-Quarter 2017 Highlights Reported net ... over the prior-year quarter. Net sales at constant currency ... reported-diluted EPS was $0.51, compared to $0.60 in the ...
Breaking Medicine Technology: