Navigation Links
Researchers develop and test new molecule as a delivery vehicle to image and kill brain tumors
Date:8/3/2011

RICHMOND, Va. (Aug. 3, 2011) A single compound with dual function the ability to deliver a diagnostic and therapeutic agent may one day be used to enhance the diagnosis, imaging and treatment of brain tumors, according to findings from Virginia Commonwealth University and Virginia Tech.

Glioblastomas are the most common and aggressive brain tumor in humans, with a high rate of relapse. These tumor cells often extend beyond the well-defined tumor margins making it extremely difficult for clinicians and radiologists to visualize with current imaging techniques. Researchers have been investigating enhanced methods of attacking these cells in order to possibly delay or prevent brain tumor relapse.

In a study published in the August issue of the journal Radiology, the research team led by Panos Fatouros, Ph.D., a former professor and chair of the Division of Radiation Physics and Biology in the VCU School of Medicine who retired in 2010, demonstrated that a nanoparticle containing an MRI diagnostic agent can effectively be imaged within the brain tumor and provide radiation therapy in an animal model.

The nanoparticle filled with gadolinium, a sensitive MRI contrast agent for imaging, and coupled with radioactive lutetium 177 to deliver brachytherapy, is known as a theranostic agent a single compound capable of delivering simultaneously effective treatment and imaging. The lutetium 177 is attached to the outside of the carbon cage of the nanoparticle.

"We believe the clustering properties of this nanoplatform prolong its retention within the tumor, thereby allowing a higher radiation dose to be delivered locally," said Michael Shultz, Ph.D., a research fellow in Fatouros' lab in the Department of Radiology in the VCU School of Medicine.

"This theranostic agent could potentially provide critical data about tumor response to therapy by means of longitudinal imaging without further contrast administration," said
'/>"/>

Contact: Sathya Abraham
sbachia@vcu.edu
804-827-0890
Virginia Commonwealth University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Stomach Cancer Tumors Have Genetic Differences: Researchers
2. Traumatic brain injury: NIH-funded researchers will assess biomarkers for diagnosis and treatment
3. Researchers map minority microbes in the colon
4. Clemson University researchers are making every bite count
5. Researchers discover method to decrease harmful cyanogens and increase protein levels in key crop
6. Obesity counseling should focus on neurobehavioral processes, not personal choice, researchers say
7. Johns Hopkins researchers discover how some breast cancers alter their sensitivity to estrogen
8. Researchers aim for direct brain control of prosthetic arms
9. Researchers work to take the pressure off newborns lungs
10. Researchers capture breakthrough data on cervical spine injuries
11. To help doctors and patients, UB researchers are developing a vocabulary of pain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Blue Cross and Blue Shield of Minnesota (Blue Cross) ... to “Live Fearless.” , The “Faces of Fearless” ... about how they or someone they know has faced a ... the moment. By telling these types of stories through livefearlessmn.com, ...
(Date:1/22/2015)... 22, 2015 Thousand of GranuFlo lawsuits ... recalled its GranuFlo and NaturaLyte dialysis concentrates continue to ... U.S. District Court, District of Massachusetts, Bernstein Liebhard LLP ... Court has remanded a case filed by the state ...
(Date:1/22/2015)... A study recently published in ... Medicine & Science in Sports & Exercise shows ... reduce gastrointestinal (GI) problems associated with physical strain ... the double-blind, placebo-controlled study took 10 grams of ...
(Date:1/22/2015)... Payday lending practices in four southern ... financial distress to the states that permit them, according ... Center on Race and Wealth. , While they generate ... loans at the same time substantially depress economic activity, ...
(Date:1/22/2015)... Lower-Auto-Insurance.com has released a new blog post explaining the ... reducing the costs of an auto insurance policy . ... get lower prices for their vehicle insurance policies. The safety a ... policy costs. Because of this, drivers should always carry a ...
Breaking Medicine News(10 mins):Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:Driving Safe And Other Factors That Make Auto Insurance Affordable! 2
... safest pain medication? Many people with osteoarthritis have ... painkillers called COX-2 inhibitors// to increased heart attack ... a COX-2 drug to other medications, including traditional ... naproxen. But although NSAIDs are effective at reducing ...
... the prestigious All India Institute of Medical Sciences (AIIMS) ... to its resident doctors association (RDA) that began early ... of AIIMS will elect eight representatives including president, vice ... Sixteen Candidates are contesting the elections that began at ...
... proof that limiting air travel can postpone the spread of flu. ... role// in the slow spread of flu across the globe every ... drop in air travel after the Sept. 11, 2001, attacks seemed ... ,“This is the first time that a study's been able ...
... watch kids comfortably settled in a beanbag, hastily nibbling from ... a television or computer screen. At a time when they ... opting for laidback activities. ,Parents, undoubtedly, have ... habit formation, as children emulate parents in their ways. In ...
... research conducted at the Hokkaido University, seaweed can be used ... of the body weight was observed in rats given fucoxanthin; ... the gut. The researchers are looking to a possibility of ... fat. Their study was presented to an American Chemical Society ...
... at the Uniformed Services University of the Health ... and the U.S. Department of Agriculture// (USDA) have ... intestinal roundworm infections, which affect more than 1.4 ... lead to more effective therapies against nematode parasites. ...
Cached Medicine News:Health News:AIIMS Goes to Polls Amid Reservation Issues 2Health News:Air travel restriction could hinder flu 2Health News:Seaweed to fight Obesity! 2Health News:Researchers Discover Breakthrough in Major Third World Scourge 2
(Date:1/22/2015)... 2015  ResMed Inc. (NYSE: RMD ) today announced ... the quarter was $423.0 million, a 10 percent increase compared ... increase on a constant currency basis). Net income was $91.2 ... ended December 31, 2013. Diluted earnings per share for the ...
(Date:1/22/2015)... DIEGO , Jan. 22, 2015  Profil Institute for ... on diabetes and obesity, announced today a new textbook,  ... Development,  published by Springer, a leading global scientific publisher. ... analyze and illustrate techniques for use in early phase ...
(Date:1/22/2015)... Jan. 22, 2015 Research and Markets ( http://www.researchandmarkets.com/research/w25xpc/allergy ... Market by Allergen Source, Product & by End User - ... The global allergy diagnostics market is valued at ... a CAGR of 12.67%, to reach $2,230.72 million by 2019. ...
Breaking Medicine Technology:ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 2ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 3ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 4ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 5ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 6ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 7ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 8ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 9ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 10ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 11New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 2New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 3Global Allergy Diagnostics (Immunoassay Analyzer, Luminometer, Assay Kit, Consumables) Market - Forecast to 2019 2Global Allergy Diagnostics (Immunoassay Analyzer, Luminometer, Assay Kit, Consumables) Market - Forecast to 2019 3
... ZANESVILLE, Ohio , May 12 Huntington Bank ... unique funding model to finance a $25 million ... region,s largest health care providers, Zanesville -based Genesis HealthCare ... install a clinical information system enabling Genesis to establish an ...
... ,, NEW YORK , May 12 Reportlinker.com announces that a new market ... , Antifungal Drugs: Technologies and ... http://www.reportlinker.com/p0196570/Antifungal-Drugs-Technologies-and-Global-Markets.html , ... , , , ...
Cached Medicine Technology:Huntington Financing Package Supports Major Regional Medical Center Electronic Medical Records Project 2Reportlinker Adds Antifungal Drugs: Technologies and Global Markets 2Reportlinker Adds Antifungal Drugs: Technologies and Global Markets 3Reportlinker Adds Antifungal Drugs: Technologies and Global Markets 4Reportlinker Adds Antifungal Drugs: Technologies and Global Markets 5Reportlinker Adds Antifungal Drugs: Technologies and Global Markets 6Reportlinker Adds Antifungal Drugs: Technologies and Global Markets 7Reportlinker Adds Antifungal Drugs: Technologies and Global Markets 8Reportlinker Adds Antifungal Drugs: Technologies and Global Markets 9Reportlinker Adds Antifungal Drugs: Technologies and Global Markets 10Reportlinker Adds Antifungal Drugs: Technologies and Global Markets 11Reportlinker Adds Antifungal Drugs: Technologies and Global Markets 12Reportlinker Adds Antifungal Drugs: Technologies and Global Markets 13Reportlinker Adds Antifungal Drugs: Technologies and Global Markets 14
... Instruments incorporate a layered design unique in ... monitored to prevent stray electrosurgical burns along ... insulation failure or capacitive coupling; a well-documented ... into all AEM Instruments provides a neutral ...
... Instruments incorporate a layered design unique in ... monitored to prevent stray electrosurgical burns along ... insulation failure or capacitive coupling; a well-documented ... into all AEM Instruments provides a neutral ...
... 5mm AEM Laparoscopic Instruments incorporate a layered ... are shielded and monitored to prevent stray ... instrument caused by insulation failure or capacitive ... protective shield built into all AEM Instruments ...
... Laparoscopic Instruments incorporate a layered design unique ... and monitored to prevent stray electrosurgical burns ... by insulation failure or capacitive coupling; a ... built into all AEM Instruments provides a ...
Medicine Products: