Navigation Links
Researchers develop a method to select eggs with the best chance of leading to successful pregnancy
Date:3/12/2008

This release is available in French.

Quebec City, March 12, 2008A research team supervised by Universit Laval scientist Marc-Andr Sirard has identified genetic markers that allow the selection of eggs with the best chance of leading to successful pregnancy after in vitro fertilization (IVF). This finding could both increase the success rate of single embryo transfer and diminish the risk of multiple pregnancies. The details of the method developed by the researchers, for which an international patent application has been filed, are explained on the website of the scientific journal Human Reproduction.

Eggs recovered in the course of the IVF process are surrounded by follicular cells that are removed before the actual fertilization procedure begins. While in the ovaries, these cells and the eggs are in very close interaction, explains Sirard. A first experiment we conducted on bovine follicular cells led us to believe that these cells might possess specific markers that would be able to give us information about the quality of an egg.

With the help of 40 women recruited in a fertility clinic, researchers compared follicular cells surrounding eggs that ultimately led to successful pregnanciesi.e. good eggsto cells surrounding ovules that did not result in pregnancy. This comparison led to the identification of five genes expressed more abundantly in follicular cells surrounding good eggs.

Currently, the way to assess which embryos are to be transferred into a womans uterus is based on visible criteria such as appearance and division rate. At least 30% of embryos that look normal through visual examination nonetheless show chromosome abnormalities, explains Professor Sirard, illustrating the limits of this type of assessment. The method developed by Sirards team makes it possible to objectively select ovules that have the best chance of success without altering the integrity of the embryos.

This new genomic tool could also solve an ethical problem confronting both fertility clinic doctors and the people who consult them: In order to increase the chances of pregnancy, many embryos are implanted simultaneously into the woman in the hope that at least one will survive. This procedure along with improved IVF techniques has led to an increase in multiple pregnancies. Even if doctors now tend to transfer fewer embryos, multiple pregnancies still occur in 30% of couples who resort to IVF in North America and 23% in European couples. By selecting the embryo with the best potential, it would be possible to limit the number of embryos transferred, and thus the number of multiple pregnancies, while maintaining good success rates, concludes Marc-Andr Sirard.


'/>"/>

Contact: Jean-Franois Hupp
jean-francois.huppe@dap.ulaval.ca
418-656-7785
Universit Laval
Source:Eurekalert

Related medicine news :

1. USC researchers find benefit for lymphoma patients in combined PET-CT scanning
2. Researchers ID behavioral risk factors for head and neck cancers
3. Red-light cameras increase crashes, researchers find
4. Leading researchers honored for progress in cancer prevention, detection and treatment
5. University of Pittsburgh researchers crack code of 3-D structure in key metabolic protein
6. UCF researchers discover a new protein family implicated in inflammatory diseases
7. Size does matter: Researchers adapt drug dosing to body size
8. Burroughs Wellcome Fund grants $9.75 million towards translational researchers
9. Researchers Design Promising Cancer Drug
10. Case Western Reserve University researchers identify colorectal cancer gene
11. On a roll: MIT researchers devise new cell-sorting system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... June 19, ... the dangers associated with chronic pain and the benefits of holistic treatments, Serenity ... who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, ... Elite. The attorneys chosen by their peers for this recognition are considered among the ... Traurig Shareholders received special honors as members of this year’s Legal Elite Hall of ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway ... call for a minimum wage raise to $12 an hour by 2020 and then adjusting ... restore the lost value of the minimum wage, assure the wage floor does not erode ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Living, is proud to recognize Dr. Barry M. Weintraub as a prominent plastic ... most beautiful women in the world, and the most handsome men, look naturally ...
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm Slone ... executive with extensive sequencing and genomics experience, as Vice President of North American Capital ... will be responsible for leading the sales team in the commercialization of the HTG ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the ... report to their offering. ... favourable commercial environment for MedImmune to enter. The US ageing ... serve to drive considerable growth for effective anti-influenza medications. The ... sales considerably, but development is still in its infancy. ...
(Date:6/23/2016)... RIDGE, Ill. and INDIANAPOLIS ... of students receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship ... The 2016 scholarship winners, announced today online at ... to let type 1 diabetes stand in the way ... Diabetes has supported the Foundation,s scholarship program since 2012, ...
(Date:6/23/2016)... N.J. , June 23, 2016  Guerbet announced ... Premier Inc.,s Supplier Horizon Award . ... year, Guerbet was recognized for its support of Premier ... creation through clinical excellence, and commitment to lower costs. ... to receive this recognition of our outstanding customer service ...
Breaking Medicine Technology: