Navigation Links
Researchers develop a method to select eggs with the best chance of leading to successful pregnancy

This release is available in French.

Quebec City, March 12, 2008A research team supervised by Universit Laval scientist Marc-Andr Sirard has identified genetic markers that allow the selection of eggs with the best chance of leading to successful pregnancy after in vitro fertilization (IVF). This finding could both increase the success rate of single embryo transfer and diminish the risk of multiple pregnancies. The details of the method developed by the researchers, for which an international patent application has been filed, are explained on the website of the scientific journal Human Reproduction.

Eggs recovered in the course of the IVF process are surrounded by follicular cells that are removed before the actual fertilization procedure begins. While in the ovaries, these cells and the eggs are in very close interaction, explains Sirard. A first experiment we conducted on bovine follicular cells led us to believe that these cells might possess specific markers that would be able to give us information about the quality of an egg.

With the help of 40 women recruited in a fertility clinic, researchers compared follicular cells surrounding eggs that ultimately led to successful pregnanciesi.e. good eggsto cells surrounding ovules that did not result in pregnancy. This comparison led to the identification of five genes expressed more abundantly in follicular cells surrounding good eggs.

Currently, the way to assess which embryos are to be transferred into a womans uterus is based on visible criteria such as appearance and division rate. At least 30% of embryos that look normal through visual examination nonetheless show chromosome abnormalities, explains Professor Sirard, illustrating the limits of this type of assessment. The method developed by Sirards team makes it possible to objectively select ovules that have the best chance of success without altering the integrity of the embryos.

This new genomic tool could also solve an ethical problem confronting both fertility clinic doctors and the people who consult them: In order to increase the chances of pregnancy, many embryos are implanted simultaneously into the woman in the hope that at least one will survive. This procedure along with improved IVF techniques has led to an increase in multiple pregnancies. Even if doctors now tend to transfer fewer embryos, multiple pregnancies still occur in 30% of couples who resort to IVF in North America and 23% in European couples. By selecting the embryo with the best potential, it would be possible to limit the number of embryos transferred, and thus the number of multiple pregnancies, while maintaining good success rates, concludes Marc-Andr Sirard.


Contact: Jean-Franois Hupp
Universit Laval

Related medicine news :

1. USC researchers find benefit for lymphoma patients in combined PET-CT scanning
2. Researchers ID behavioral risk factors for head and neck cancers
3. Red-light cameras increase crashes, researchers find
4. Leading researchers honored for progress in cancer prevention, detection and treatment
5. University of Pittsburgh researchers crack code of 3-D structure in key metabolic protein
6. UCF researchers discover a new protein family implicated in inflammatory diseases
7. Size does matter: Researchers adapt drug dosing to body size
8. Burroughs Wellcome Fund grants $9.75 million towards translational researchers
9. Researchers Design Promising Cancer Drug
10. Case Western Reserve University researchers identify colorectal cancer gene
11. On a roll: MIT researchers devise new cell-sorting system
Post Your Comments:
(Date:11/25/2015)... Raton, Florida (PRWEB) , ... November 25, 2015 ... ... diagnostic testing for physicians and athletic programs, launches new Wimbledon Athletics ... importance of testing young athletes for unsuspected cardiac abnormalities. About 2,000 people under ...
(Date:11/25/2015)... Calif. (PRWEB) , ... November 25, 2015 , ... Beddit® ... and Beddit Classic sleep tracking systems. The new app features a more intuitive SleepScore™ ... and understand how well you slept. The SleepScore is created by a proprietary algorithm. ...
(Date:11/25/2015)... LOUIS, Missouri (PRWEB) , ... November 25, 2015 ... ... Project HEAL, will provide scholarships for people struggling with eating disorders as a ... Proceeds from the second annual event, held at Fox Run Golf Club in ...
(Date:11/25/2015)... , ... November 25, 2015 , ... Many people know ... fuzzy-headedness, weight gain, cold hands, and dry skin. But many people who find their ... and exercise regimen instead of their thyroid, especially if they don’t have any of ...
(Date:11/24/2015)... ... 2015 , ... Genesis Chiropractic Software helps practice owners automate ... between the practice owner and the patient that automatically manages all five aspects ... Click here to learn more. , According to Dr. Brian ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... 2015  ARKRAY USA , Inc., ... evidence demonstrating the accuracy of its blood glucose meter ... Resistance, Diabetes and Cardiovascular Disease in Los ... GLUCOCARD ® 01 meter and the Assure ® ... ability to accurately measure glucose levels in blood is ...
(Date:11/25/2015)... Israel , November 25, 2015 ... KTOV ) (TASE: KTOV), a biopharmaceutical company focused ... treatment of various clinical conditions, today announced the closing ... American Depository Shares ( ADSs ), each representing 20 ... up to 3,158,900 ADSs. The ADSs and warrants were ...
(Date:11/25/2015)... DIEGO , Nov. 25, 2015  Trovagene, Inc. ... diagnostics, today announced that Chief Executive Officer Antonius Schuh, ... the 27 th Annual Piper Jaffray Healthcare Conference. ... at the New York Palace Hotel in ... at 1:30 p.m. EST. Mr. Schuh will be available ...
Breaking Medicine Technology: