Navigation Links
Researchers develop DNA 'patch' for canine form of muscular dystrophy
Date:3/16/2009

mutations that affect multiple exons, and so would require more than one kind of patch. The dogs in the study carried a mutation affecting multiple exons. The researchers used a cocktail containing multiple DNA patches to bypass the affected exons.

The patches, DNA-like molecules called morpholinos, are manufactured in a laboratory. Injections of the morpholino cocktail directly into the dogs' bloodstream curbed deterioration of the animals' skeletal muscles and improved muscle functioning. The injections resulted in widespread production of dystrophin-like protein, at about 26 percent of normal levels. However, the treatment was unable to prevent deterioration of the animals' hearts. The researchers theorized that the muscles of the heart are less porous than the skeletal muscles, and did not absorb sufficient quantities of the morpholinos to curb the deterioration.

The researchers said that other means of delivering the morpholinos to the heart would need to be explored.

They added, however, that the study results showed that it would be possible to use a cocktail of morpholinos to patch the multiple mutations that occur in the human form of the disorder.


'/>"/>

Contact: Robert Bock
bockr@mail.nih.gov
301-496-5133
NIH/National Institute of Child Health and Human Development
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... LSU Health New Orleans School of Nursing was ... to increase access to advanced nursing education and ... as well as veterans. The Health Resources and ... and Human Services awarded the two-year grant. Scharalda ... project director., The Advanced Education Nursing Traineeship (AENT) ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 Beat ... how they can use natural methods to completely cure ... caught the attention of Shane Michaels, prompting an investigative ... that affects the skin, it can still be extremely ... reports Michaels. “The intense itching and pain that it ...
(Date:8/22/2014)... a complex autoimmune disease that affects 1 to ... only cope with pain, disability and joint disfigurements, ... family life and marital functioning. While many pharmacological ... disability is common. In addition, some patients avoid ... side effects. Because of this, there is interest ...
(Date:8/22/2014)... Chicago, IL (PRWEB) August 22, 2014 ... become a thriving fertility destination, and now offers the ... interdisciplinary team of infertility specialists. The fertility network of ... an overall commitment to world-class reproductive care, female and ... program lives up to the standards so eminently set ...
(Date:8/22/2014)... 22, 2014 (HealthDay News) -- Back-to-school time provides an ... fits into the family schedules, an expert suggests. ... school year can also be the start of a ... a professor of kinesiology at the University of the ... With kids, extracurricular activities likely to build up, ...
Breaking Medicine News(10 mins):Health News:Beat Eczema: Review Exposes Susan Clark’s Guide to Curing Eczema Naturally 2Health News:Study shows cognitive-behavioral coping skills training has positive effects on rheumatoid arthritis 2Health News:Mexico Now Offers Top Program for Couples Suffering from Male Infertility 2Health News:Mexico Now Offers Top Program for Couples Suffering from Male Infertility 3Health News:Mexico Now Offers Top Program for Couples Suffering from Male Infertility 4Health News:With Kids in School, Parents Can Work Out 2
... July 2008 Elsevier, a leading publisher of scientific, technical ... the official journal of the European Association of Urology ... , European Urology (also the "Platinum ... response and an international profile. To keep up with the ...
... Milwaukee-based Assurant Health, a,leading national provider of ... products, announces that Jennifer Kopps-Wagner has been,named ... immediately., Kopps-Wagner joined Assurant Health in ... company,s legal department. In her most recent ...
... LOUIS, July 16 Stereotaxis, Inc. (Nasdaq:,STXS) announced ... Heart and,Diabetes Center of North Reinland-Westphalia in Bad ... in a 10-year old boy. The team performed ... Pulmonary atresia is a congenital malformation of the ...
... New Center for Excellence Issue Brief, WASHINGTON, ... Government Excellence has issued its first issue brief ... Local Government Retiree Health,Benefit Plans: Myths and Realities. ... professor of economics and management, innovation, and,entrepreneurship in ...
... exemplify perseverance, ST. LOUIS, July 16 There,s ... their votes. They can vote online,and vote now for ... to elect,a new member of the 2008 Energizer(R) Keep ... of Fame celebrates everyday people whose,attributes and actions best ...
... 26 Grand Opening Festivities Will Include Health Education Fair,Tour ... "9 Steps to Optimum,Health", HUNTERSVILLE, N.C., July 16 ... is dedicated to successfully treating,diseases that were previously thought ... level of health, today announced that it will open,the ...
Cached Medicine News:Health News:Assurant Health Names Jennifer Kopps-Wagner Senior Vice President and General Counsel 2Health News:Stereotaxis Magnetic Navigation System Used to Successfully Treat an Inoperable Congenital Heart Defect in a 10-Year Old Patient 2Health News:Stereotaxis Magnetic Navigation System Used to Successfully Treat an Inoperable Congenital Heart Defect in a 10-Year Old Patient 3Health News:The Crisis in State and Local Government Retiree Health Benefit Plans: Myths and Realities 2Health News:Vote now for an Everyday Person with Never-Quit Spirit to join the Energizer(R) Keep Going(R) Hall of Fame 2Health News:Vote now for an Everyday Person with Never-Quit Spirit to join the Energizer(R) Keep Going(R) Hall of Fame 3Health News:Vote now for an Everyday Person with Never-Quit Spirit to join the Energizer(R) Keep Going(R) Hall of Fame 4Health News:Vote now for an Everyday Person with Never-Quit Spirit to join the Energizer(R) Keep Going(R) Hall of Fame 5Health News:North Carolina's Center For Advanced Medicine & Clinical Research Celebrates Opening of New LKN Medical Spa and Rejuvenation Center 2Health News:North Carolina's Center For Advanced Medicine & Clinical Research Celebrates Opening of New LKN Medical Spa and Rejuvenation Center 3
(Date:8/22/2014)... /CNW/ - On Aug. 20, at its annual meeting ... Association (CMA) voted on and approved a delegate resolution ... cannabis. Bedrocan Cannabis Corp., a leading Canadian licensed producer ... The CMA is quite right to point ... any plant material, including medicinal cannabis. While some patients, ...
(Date:8/22/2014)... 22, 2014 Research and Markets  has ... Products: Opportunities, Tools & Technologies" report to their ... cell research products or you wish to expand your ... this market is. The authors know you want to ... to scientists, to generate improved revenues and take market ...
(Date:8/22/2014)... 2014  Dr. Mark Rasak , MD is ... Achievement Award in the field of Medicine as a ... Associates. Dr. Rasak has over 15 years ... of the business; overseeing the daily operations; interventional cardiology; ... In addition, he is an honored Fellow of the ...
Breaking Medicine Technology:Bedrocan Canada Statement Regarding Canadian Medical Association Motion on Smoking Marijuana 2Global Stem Cell Research Products: Opportunities, Tools & Technologies - 2014 Report 2Global Stem Cell Research Products: Opportunities, Tools & Technologies - 2014 Report 3Dr. Mark Rasak, MD is recognized by Continental Who's Who with the Diamond Lifetime Achievement Award 2
... Aug. 25, 2011 DDS Lab, a national dental ... innovation with Fierce mouthguards. Available in over twenty-seven colors ... mouthguards meet the needs of any athlete, from gymnasts ... Foundation for Safety, an athlete is 60 times more ...
... SPRING, Md., Aug. 25, 2011 The U.S. Food and ... of acute attacks of a rare condition called hereditary angioedema ... (Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO ) ... levels or the improper function of a protein called C1 ...
Cached Medicine Technology:DDS Lab Launches Fierce™ Mouthguards 2FDA Approves Firazyr To Treat Acute Attacks of Hereditary Angioedema 2
... is the most common cause ... 5% of pediatric visits and ... under 5 years. ImmunoSTAT! Rotatvirus ... rule in or rule out ...
The CdTOX A OIA gets the results you need without specimen extraction or instrumentation. Results are available in minutes vs hours or days for EIA or other methods. The combination of performance, ...
... Ideal for Botox therapy and ... stainless steel injectable needle has a ... touchproof connector with an attached 61-cm ... for easy insertion. Single patient use ...
... Back Relief Apron has standard ... the weight from the shoulders ... aid of a 6" wide ... strap keeps apron snug. Belts ...
Medicine Products: