Navigation Links
Researchers determine vitamin D blood level for reducing major medical risks in older adults
Date:5/1/2012

In testing older patients' blood vitamin D levels, there's uncertainty about where the dividing line falls between enough and not enough. The threshold amount has become controversial as several scientific societies set different targets.

To help resolve this debate, University of Washington researchers conducted an observational study. They wanted to learn how much vitamin D must be circulating in the blood to lower the risk of a major medical event. This category included heart attack, hip fracture, diagnosis of cancer, or death.

Their findings are reported today, May 1, in the Annals of Internal Medicine. Dr. Ian de Boer, assistant professor of medicine in the Division of Nephrology and a member of the Kidney Research Institute, led the project. He also holds an appointment in the Department of Epidemiology, UW School of Public Health.

Vitamin D is measured in the blood as 25-hydroxy-vitamin D, abbreviated 25(OH)D.

The researchers tested 25(OH)D concentrations from a biorepository of blood samples of 1,621 Caucasian adults. These adults had enrolled in the early 1990s in the Cardiovascular Health Study, originally designed to look at risk factors and progression of heart disease in people age 65 and over. The participants lived in one of four areas in the United States: Forsyth County, North Carolina; Sacramento, County, California; Washington County, Maryland; and Philadelphia, Pennsylvania.

Over about an 11-year follow-up, researchers looked at the association between each individual's 25(OH)D test results and the time that a first defining medical event occurred. Among the participants, 1,018 had such an event. There were 137 hip fractures, 186 heart attacks (myocardial infarctions), 335 incidences of cancer, and 360 deaths.

Through their statistical analysis, the researchers concluded that the risk of these disease events rose when the concentration of 25(OH)D fell below 20 ng/milliliter or 50 nmol/liter.

"Our results," de Boer said, "lend support to the threshold level recently recommended by the Institute of Medicine, a national, independent government advisory group."

He added, "This target level for adults is considerably lower than that set by other expert panels.'

His research team also found that the association of low 25(OH)D blood concentrations with risk of major disease events varied with the season. Because people soak up most of their Vitamin D from the sun, their levels run highest in the summer and lowest in the winter. Levels in autumn are generally above those in spring.

"In evaluating health risk," the researchers concluded, "Season-specific targets for 25(OH)D blood concentration may be more appropriate than a static target when evaluating patients health risk."

Future research in this area, de Boer said, will require clinical trials. Researcher will look, for example, at the health effects of attempts to raise 25(OH)D in patients whose levels fall below the target. Interventions might include supplements, dietary changes and increasing outdoor activity.

"Sun exposure is tricky," de Boer said, "because people have to protect themselves from skin cancer and other sun damage." Sunscreen blocks the UVB waves responsible for producing Vitamin D. Food sources for Vitamin D are milk, fortified juice and cereal and oily fish like salmon, mackerel, cod and herring.

Vitamin D provides many different beneficial effects on health because it is actually not a vitamin, but a prohormone. It can suppress the hormonal systems that cause fluid to be retained and blood pressure to go up, modulate the function of immune cells, and stop abnormal cells from overgrowing.


'/>"/>

Contact: Leila Gray
leilag@uw.edu
206-685-0381
University of Washington
Source:Eurekalert  

Related medicine news :

1. Researchers creating designer lymph nodes based on Moffitts Total Cancer Care initiative
2. Moffitt researchers find adolescents with cancer concerned about their future reproductive health
3. Moffitt Cancer Center researchers working at frontiers of melanoma research
4. Moffitt Cancer Center researchers: Quality of life as important as quantity of life
5. UCLA researchers combat global disease with a cell phone, Google Maps and a lot of ingenuity
6. Spinal cord injury researchers win Apple Award for article on niacin for dyslipidemia
7. Moffitt researchers find cancer therapies affect cognitive functioning among breast cancer survivors
8. Gene Behind Psoriasis Identified, Researchers Say
9. McMaster researchers find potential for new uses of old drug
10. Football helmet sensors help researchers demystify concussion in young athletes
11. Researchers Repair Damage Caused by Heart Attacks in Mice
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers determine vitamin D blood level for reducing major medical risks in older adults
(Date:1/21/2017)... Santa Rosa, CA (PRWEB) , ... January 21, ... ... announce the opening of its new medical office in Petaluma, located at 167 ... full-service casting room, access to SRO sports medicine and rehabilitation services ...
(Date:1/20/2017)... Abilene, Texas (PRWEB) , ... January 20, 2017 , ... Yisrayl Hawkins, Pastor and Overseer ... back the bible in homes across the world. Yisrayl says this generation is a time ... better is to turn to the Bible. , Yisrayl says he does not want to ...
(Date:1/20/2017)... ... January 20, 2017 , ... ATP Science, an Australian-based company ... attended the January ECRM Trade Show in Hilton Head, SC, benefiting from outstanding ... range of supplements that keep the body functioning at its peak performance by ...
(Date:1/20/2017)... ... January 20, 2017 , ... “Mary Magdalene: Grace is Greater than Sin”: ... who witnessed Jesus Christ firsthand. “Mary Magdalene: Grace is Greater than Sin” is the ... an educator interacting with countless women who had little knowledge of the female characters ...
(Date:1/20/2017)... ... ... “Christmas in Suffolk”: a story of love, secrets, and mystery. “Christmas in Suffolk” ... she works in a daycare and looks for inspiration in the local coffee shop ... Sara Seymour’s new book is an adventure of love and secrets. , ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)...  Ethicon Endo-Surgery, Inc. announced today that ... a privately held medical device company that ... in operating rooms worldwide. The acquisition brings ... devices with Megadyne,s innovative portfolio of electrosurgical ... Ethicon,s goal to deliver the most comprehensive ...
(Date:1/20/2017)... 2017 Research and Markets has announced ... Opportunities, and Future" report to their offering. ... This research service on the ... technologies, and provides a snapshot of the key participants in the ... are provided from 2016 to 2020. The market is expected to ...
(Date:1/20/2017)... 2017 Wells Specialty Pharmacy announces the acquisitions and ... in Winter Park, Florida and Pharm-EZ ... Operations have been consolidated into the 3796 Howell Branch Road ... announce that Chad Tomlinson , former Vice President of ... immediately. Mr. Tomlinson is a Graduate of Florida State University ...
Breaking Medicine Technology: