Navigation Links
Researchers determine pathway for origin of most common form of brain and spinal cord tumor
Date:6/13/2012

, a type of lung cancer mostly associated with exposure to asbestos.

In their research, the investigators collected 70 human meningioma tissue samples and found that YAP1 expression was present in the nuclei of all of the samples, regardless of tumor "grade," meaning it appears to be a molecular mechanism involved in the earliest stages of meningioma development. In the lab, Baia knocked down the amount of YAP1 in cell nuclei and found that tumor proliferation went down. When there was more YAP1, the cells grew and also migrated more.

Baia and his team also injected human cell lines in which YAP1 was overexpressed into the brains of the mice. "With excess YAP, all of the mice got tumors," Baia says.

The next step, Baia says, is to determine the exact genes activated by the arrival of YAP1 in the cell nuclei. Then, the hope is, new treatments can be developed to target those genes, he adds.


'/>"/>

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UCI researchers create mosquitoes incapable of transmitting malaria
2. Moffitt Cancer Center researchers develop and test new anti-cancer vaccine
3. Penn and Cornell researchers spearhead the development of new guidelines for veterinary CPR
4. VCU researchers identify changes in cholesterol metabolic pathways
5. An important breakthrough in immunology by IRCM researchers
6. Mount Sinai researchers develop a multi-target approach to treating tumors
7. Doubling down on heart failure: Researchers discover new route to disease, and drugs to match
8. Researchers at IRB Barcelona uncover new clues about the origin of cancer
9. HIV drug may slow down metastatic breast cancer, say researchers at Jeffersons Kimmel Cancer Center
10. Student researchers seek to develop new therapies for cancer
11. Researchers call for obesity prevention efforts to focus on community-wide systems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2015)... Join Fiona's Soccer Camp at Novato High School's Tibi ... National Player, Fiona O'Sullivan will be on site to run ... coaching style. Fiona has three camps running this summer in ... Lynwood Elmentary School (June 15-19) and Hill Recreation Center (June ... 2015 - 1:00-3:00pm. Bring a Soccer Ball, Cleats and a ...
(Date:5/24/2015)... (PRWEB) May 25, 2015 Pacific Prime has announced ... part report looking at the cost of individual international health ... Article 2 looks at the cost of health insurance in six ... Focusing on, Hong Kong , ... the UAE , the UK , ...
(Date:5/24/2015)... NC (PRWEB) May 24, 2015 Scientists ... a paper on air quality compliance issues that may ... American workers. Surviving Mesothelioma has just posted an article ... now. , The group found airborne asbestos levels ... data collected between 1984 and 2011. , “Asbestos compliance ...
(Date:5/24/2015)... Scottsdale, Arizona (PRWEB) May 24, 2015 ... hired former Millennial Media strategy executive Jay Krihak ... as Medicx looks to ramp up its expertise ... services of the Pharmaceutical and Health sectors. , ... ad tech executive. Most recently, Krihak led sales ...
(Date:5/23/2015)... CA (PRWEB) May 23, 2015 Dr. David ... California, has just posted a new article to ... repair. As Dr Benvenuti explained in the fascinating ... enlarged plugs in their earlobes. , Known as “gauging,” the ... earlobe hole, which Dr. Benvenuti said will eventually stretch the ...
Breaking Medicine News(10 mins):Health News:US Sports Camps and Nike Soccer Camps Offer Complimentary Instructional Clinic with Fiona's Soccer Camp 2Health News:Pacific Prime Releases 2nd Article of Cost of Health Insurance Report 2Health News:New Analysis Finds Too Many Employers Ignored OSHA Asbestos Guidelines, According to Surviving Mesothelioma 2Health News:Medicx Media Solutions Expands Executive Team 2Health News:Dr. Benvenuti, a Plastic Surgeon in Newport Beach, CA, Posts New Article about Repairing Ear Gauges 2
... of the most vital treatment steps in recovery from hand ... August 2010 issue of the Journal of the American ... spend more time with the hand therapist than the orthopaedic ... long-term recovery. "Hand therapy is the critical link between ...
... MONDAY, Aug. 2 (HealthDay News) -- Children in an African ... until the age of 2 had vastly different gut bacteria ... diet and were breast-fed about only half that time. ... may predispose these children to become obese and develop allergies ...
... Boston, Mass. -- When published results are systematically tracked ... trials are the likeliest to be favorable to the ... Publishing in the August 3 issue of the ... more public disclosure about clinical drug trials at their ...
... and dentists have more in common than one might ... Both are subject to human error where small, individual ... A dental professor at the University of Michigan ... safety procedures in dental offices similar to procedures used ...
... HealthDay Reporter , MONDAY, August 2 (HealthDay News) ... higher than normal are at greater risk of developing ... hardening of the arteries leading to heart disease, a ... the common assumption that modestly high cholesterol levels are ...
... The Louisiana Tumor Registry (LTR) at the LSU Health ... been awarded a $12 million contract over seven years ... as a SEER (Surveillance, Epidemiology and End Results) Program-designated ... registries in the United States., "The SEER Program is ...
Cached Medicine News:Health News:Keeping patients 'in good hands' 2Health News:Western Diet Populates Kids' Stomachs With Bad Bacteria 2Health News:Western Diet Populates Kids' Stomachs With Bad Bacteria 3Health News:Drug trials funded by industry are more likely to publish favorable results 2Health News:Drug trials funded by industry are more likely to publish favorable results 3Health News:Pilot safety protocol could help dentists reduce errors 2Health News:High Cholesterol in Youth Boosts Heart Risk In Middle Age 2Health News:High Cholesterol in Youth Boosts Heart Risk In Middle Age 3Health News:High Cholesterol in Youth Boosts Heart Risk In Middle Age 4Health News:LA Tumor Registry at LSUHSC awarded $12 million SEER contract by NCI 2Health News:LA Tumor Registry at LSUHSC awarded $12 million SEER contract by NCI 3
(Date:5/22/2015)... , May 22, 2015  RegeneRx Biopharmaceuticals, Inc. ... tissue protection, repair and regeneration, today announced that ... scheduled to present a corporate overview at two upcoming ... at the SeeThruEquity 4 th Annual Microcap Conference ... York City at 11:00 am EDT.  A ...
(Date:5/22/2015)... , May 22, 2015  The Mesothelioma Victims ... victims of mesothelioma get the best possible compensation, ... individuals with this rare cancer caused by exposure ... up-to-date information related to treatment options such as ... call the Mesothelioma Victims Center anytime at 866-714-6466. ...
(Date:5/22/2015)... , May 22, 2015 Research and ... the addition of the "Latest Regulations on ... report to their offering. This is ... issued a guidance on international multi-center clinical trials ... which has begun to be implemented on March ...
Breaking Medicine Technology:RegeneRx to Present at 2 Investor Conferences 2RegeneRx to Present at 2 Investor Conferences 3Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 2Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 3Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 4Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 52015 Regulations on Pharmaceutical International Multi-Center Clinical Trials in China 2
... at AACR, SAN DIEGO, April 17 /PRNewswire-FirstCall/ ... in vitro study showing,that the active metabolite ... response by inducing cytokine secretion,cytolysis of tumor ... a poster presentation at the Annual,Meeting of ...
... ANGELES, April 17, 2007 /PRNewswire/ -- Researchers from ... presented,strong evidence today that an antibiotic typically prescribed ... types of cancers. , Q. Ping Dou, Ph.D., ... lab announced the findings of their study showing,that ...
Cached Medicine Technology:Anadys Reports Preclinical Data Showing ANA773 Promotes Anti-Tumor,Activity of Natural Killer Cells 2Anadys Reports Preclinical Data Showing ANA773 Promotes Anti-Tumor,Activity of Natural Killer Cells 3Anadys Reports Preclinical Data Showing ANA773 Promotes Anti-Tumor,Activity of Natural Killer Cells 4Alzheimer's Drug Shows Promise in Fighting Cancer 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: