Navigation Links
Researchers determine pathway for origin of most common form of brain and spinal cord tumor
Date:6/13/2012

, a type of lung cancer mostly associated with exposure to asbestos.

In their research, the investigators collected 70 human meningioma tissue samples and found that YAP1 expression was present in the nuclei of all of the samples, regardless of tumor "grade," meaning it appears to be a molecular mechanism involved in the earliest stages of meningioma development. In the lab, Baia knocked down the amount of YAP1 in cell nuclei and found that tumor proliferation went down. When there was more YAP1, the cells grew and also migrated more.

Baia and his team also injected human cell lines in which YAP1 was overexpressed into the brains of the mice. "With excess YAP, all of the mice got tumors," Baia says.

The next step, Baia says, is to determine the exact genes activated by the arrival of YAP1 in the cell nuclei. Then, the hope is, new treatments can be developed to target those genes, he adds.


'/>"/>

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. UCI researchers create mosquitoes incapable of transmitting malaria
2. Moffitt Cancer Center researchers develop and test new anti-cancer vaccine
3. Penn and Cornell researchers spearhead the development of new guidelines for veterinary CPR
4. VCU researchers identify changes in cholesterol metabolic pathways
5. An important breakthrough in immunology by IRCM researchers
6. Mount Sinai researchers develop a multi-target approach to treating tumors
7. Doubling down on heart failure: Researchers discover new route to disease, and drugs to match
8. Researchers at IRB Barcelona uncover new clues about the origin of cancer
9. HIV drug may slow down metastatic breast cancer, say researchers at Jeffersons Kimmel Cancer Center
10. Student researchers seek to develop new therapies for cancer
11. Researchers call for obesity prevention efforts to focus on community-wide systems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2013)... Buenos Aires, Argentina: Yoga classes ( clases de Yoga ... by the Sivananda Yoga Vedanta Center. The center ... Norte). Classes are 90 minutes and are offered all ... a calm environment, allowing visitors to enjoy the benefits ... among others. , The Yoga classes follow the following ...
(Date:5/19/2013)... Minor fender benders and serious car accidents are common ... accident to respond appropriately to the situation. According ... from 2010, accidents, including car accidents, are the fifth ... 2005, automobile accident-related deaths cost over $70 ... drivers and passengers receive treatment in an emergency room ...
(Date:5/18/2013)... (PRWEB) May 18, 2013 Cambridge House ... the St. Louis Metro East area, is hosting a Memorial ... Friday, May 24. , The community, which is located at ... of all incomes, including those on Medicaid, who need some ... delicious BBQ luncheon topped off by homemade ice cream for ...
(Date:5/18/2013)... The American Society for Gastrointestinal Endoscopy (ASGE) will honor ... ninth annual ASGE Crystal Awards on Sunday, May 19, ... year,s event will begin at ... Held in conjunction with Digestive Disease Week (DDW), the ... and scientific pursuit. The event will recognize the 2013 ...
(Date:5/18/2013)... California (PRWEB) May 18, 2013 Also ... is an increasingly popular weight loss surgery that guarantees ... Lap Band Center wishes to give readers a ... Dr. Naim attended medical school at New York City’s ... New York Methodist he undertook a fellowship in Minimally ...
Breaking Medicine News(10 mins):Health News:Clases de Yoga in Buenos Aires, Argentina (Yoga Classes) Now Offered by Sivananda Yoga Vedanta Center 2Health News:Auto Accident Infographic Issued by d’Oliveira & Associates on Steps to Take After a Car Crash 2Health News:Metro East Affordable Assisted Living Community to Host Memorial Day Weekend Barbecue 2Health News:ASGE and ASGE foundation hold Crystal Awards dinner as part of Digestive Disease Week®, May 19, in Orlando 2Health News:ASGE and ASGE foundation hold Crystal Awards dinner as part of Digestive Disease Week®, May 19, in Orlando 3Health News:ASGE and ASGE foundation hold Crystal Awards dinner as part of Digestive Disease Week®, May 19, in Orlando 4Health News:ASGE and ASGE foundation hold Crystal Awards dinner as part of Digestive Disease Week®, May 19, in Orlando 5Health News:ASGE and ASGE foundation hold Crystal Awards dinner as part of Digestive Disease Week®, May 19, in Orlando 6Health News:ASGE and ASGE foundation hold Crystal Awards dinner as part of Digestive Disease Week®, May 19, in Orlando 7Health News:Everything You Need to Know About Lap Band Surgery 2Health News:Everything You Need to Know About Lap Band Surgery 3
... An international team of researchers has identified a new ... that affects development of the cerebellum and brainstem-the ... basic functions such as breathing, swallowing, heart rate and ... has been found to have association with Joubert syndrome. ...
... Department of Energys Oak National Laboratory has developed a new ... between human activity and climate change. ,The ... time variable like a 100-year rainfall at two locations or ... more variables such as 100-year precipitation extremes and heat waves. ...
... the University of Washington and other members of an ... human genome functions . While previous studies of the ... provides insight into the non-gene sequences making up the ... in non-gene sequences are so-called "regulatory elements" that contain ...
... a new study by researchers in National Institutes of ... dementia increases with the number of different disease processes ... findings is the observation that the combination of Alzheimers ... mix of pathologies in the brains of people with ...
... Research will be convened in Vancouver from June 13 to ... clinicians and scientists examining many aspects of hair disease ... thick, loosing hair can weaken a person emotionally. Hair loss ... influence career advancement and emotional well being, adds Shapiro, who ...
... his beams! , So shines a good deed in a ... ,14th of June is celebrated universally as the 'World Blood Donor ... Prize winner, who discovered the ABO blood group system. ... of World Health Day, 2000, which was devoted to the theme ...
Cached Medicine News:Health News:Boffins Identify Fifth Gene Behind Joubert Syndrome 2Health News:Indo-American Develops Model Linking Human Activity to Climate Change 2Health News:Researchers Cracking the Human Genome Function 2Health News:Researchers Cracking the Human Genome Function 3Health News:Mix of Disease Process in Brain Leads to Dementia 2Health News:World Largest Hair Congress Convene in Vancouver 2Health News:World Blood Donor Day 2
(Date:5/16/2013)... May 16, 2013  Nektar Therapeutics, (Nasdaq: NKTR ... Robin , is scheduled to present at the upcoming ... at the Sheraton New York Hotel on Tuesday, ... The presentation will be accessible via a Webcast through a ... the Nektar website: http://www.nektar.com . This Webcast will be ...
(Date:5/16/2013)... SYDNEY , May 16, 2013  HeartWare International, ... leading innovator of less invasive, miniaturized circulatory support technologies that ... that CEO Doug Godshall is scheduled ... 11:00 a.m. EDT on Monday, May 20, 2013.  The conference ... York Hotel. A live webcast of the Company,s ...
(Date:5/16/2013)... , May 16, 2013  Amgen (NASDAQ: AMGN ... on Tuesday, May 21, 2013, at the Sheraton New York ... beginning at 10:00 a.m. Eastern Daylight Time. Joseph ... Research and Development at Amgen, will present at the conference. ... Events Calendar on Amgen,s website, www.amgen.com , under Investors. ...
Breaking Medicine Technology:Nektar Therapeutics' President and CEO, Howard W. Robin, To Present at the 2013 UBS Global Healthcare Conference in New York City 2HeartWare Presentation At The 2013 UBS Global Healthcare Conference To Be Webcast 2
... Adlea May Provide Pain Relief Without Opiate-Like Side Effects For ... Months Following a Single ... (Nasdaq: ANSV ) today announced that it has initiated ... relief of post-operative,pain in patients undergoing total knee replacement surgery, ...
... for,Hispanic Health (the Alliance) is launching a new ... Hands (Presion alta ... El control esta,en tus ... hypertension (high,blood pressure), promoting prevention, and helping Hispanic ... Alliance is conducting,education and blood pressure screening events ...
Cached Medicine Technology:Anesiva Initiates New Phase 2 Trial of Adlea(TM) for Pain Relief Following Knee Replacement Surgery 2Anesiva Initiates New Phase 2 Trial of Adlea(TM) for Pain Relief Following Knee Replacement Surgery 3Anesiva Initiates New Phase 2 Trial of Adlea(TM) for Pain Relief Following Knee Replacement Surgery 4Uncontrolled Blood Pressure Highest Among Hispanics, Prompting New Hypertension Project in Miami 2Uncontrolled Blood Pressure Highest Among Hispanics, Prompting New Hypertension Project in Miami 3
... New 2.2 Fr Sur-Catch NT stone retrieval basket ... level. Its unique paired wire design and ... to the needs of each patient and procedure. ... specifically for use with the DURTM-8 Elite Ureteroscope ...
The Surgiflex WAVE XP couples the state-of-the-art Surgiflex WAVE Probe with the convenience of a truly portable battery-powered pump....
The Surgiflex WAVE XP couples the state-of-the-art Surgiflex WAVE Probe with the convenience of a truly portable battery-powered pump....
The original battery-operated suction and irrigation system features a new ergonomic hand piece and superior performance characteristics that have increased the overall flow rate....
Medicine Products: