Navigation Links
Researchers determine pathway for origin of most common form of brain and spinal cord tumor
Date:6/13/2012

, a type of lung cancer mostly associated with exposure to asbestos.

In their research, the investigators collected 70 human meningioma tissue samples and found that YAP1 expression was present in the nuclei of all of the samples, regardless of tumor "grade," meaning it appears to be a molecular mechanism involved in the earliest stages of meningioma development. In the lab, Baia knocked down the amount of YAP1 in cell nuclei and found that tumor proliferation went down. When there was more YAP1, the cells grew and also migrated more.

Baia and his team also injected human cell lines in which YAP1 was overexpressed into the brains of the mice. "With excess YAP, all of the mice got tumors," Baia says.

The next step, Baia says, is to determine the exact genes activated by the arrival of YAP1 in the cell nuclei. Then, the hope is, new treatments can be developed to target those genes, he adds.


'/>"/>

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UCI researchers create mosquitoes incapable of transmitting malaria
2. Moffitt Cancer Center researchers develop and test new anti-cancer vaccine
3. Penn and Cornell researchers spearhead the development of new guidelines for veterinary CPR
4. VCU researchers identify changes in cholesterol metabolic pathways
5. An important breakthrough in immunology by IRCM researchers
6. Mount Sinai researchers develop a multi-target approach to treating tumors
7. Doubling down on heart failure: Researchers discover new route to disease, and drugs to match
8. Researchers at IRB Barcelona uncover new clues about the origin of cancer
9. HIV drug may slow down metastatic breast cancer, say researchers at Jeffersons Kimmel Cancer Center
10. Student researchers seek to develop new therapies for cancer
11. Researchers call for obesity prevention efforts to focus on community-wide systems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... December 15, 2014 Cancer researchers have ... underlying genetic causes of deadly malignant pleural mesothelioma. Surviving ... on their website. Click here to read it ... of Hawaii Cancer Center, and New York’s Langone Medical ... pleural mesothelioma patients in an effort to pinpoint ...
(Date:12/15/2014)... Main Street Dental Team ( http://www.MainStreetDentalTeam.com ), Unionville’s ... new study providing evidence on the impact of 100% ... , Sufficient enough evidence already exists showing a negative ... drinks, with the onset of tooth decay. One question ... as 100% fruit juice, meaning it is completely natural ...
(Date:12/15/2014)... SIMpalm, a leading mobile app development company , ... client, which allows users to keep track of wines ... the right wine. At the center of WineMatch ... and wine information. All this information is assembled to ... that are close counterparts to one another are called ...
(Date:12/15/2014)... 15, 2014 Health Dialog, a ... today that it has received Patient Oriented Accreditation ... for its Disease Management (DM) Programs for asthma, ... coronary heart disease and diabetes. This marks the ... Health Dialog’s Disease Management (DM) Programs, reaffirming Health ...
(Date:12/15/2014)... (HealthDay News) -- Expert pilots process visual information more ... make better decisions during landings, a new study shows. ... for pilots to master, and 36 percent of all ... during final approach and landing. Researchers monitored the ... experienced pilots while they were at the controls of ...
Breaking Medicine News(10 mins):Health News:New Study Reveals Genetic Mutations That May Trigger Mesothelioma, According to Surviving Mesothelioma 2Health News:Main Street Dental Team, Unionville’s Most Innovative Dental Clinic, Comments on New Study Relating Pure Fruit Juice to Poor Oral Hygiene 2Health News:Use WinMatch Connect App to Keep Track of Wines You Like 2Health News:Health Dialog Receives NCQA Accreditation for Disease Management Programs 2Health News:Study Shows Why Expert Pilots Are Experts 2
... July 11 The Natural Orifice Surgery Consortium ... of the American Society for Gastrointestinal Endoscopy (ASGE) ... Surgeons (SAGES), today announced Olympus, continuing commitment to ... therapy known as Natural Orifice Translumenal Endoscopic Surgery(R), ...
... With the two year ... provider, has seen a 70 percent increase in women booking themselves in for botox and fillers ... ... the smoking ban upon us (1st July 2009), SurgiCare, a leading UK cosmetic surgery ...
... American ... providers of nutritional supplements and health-related content, today announced that Jim Barch has joined Healthy ... ... and ACI Capital , majority owners of Healthy Directions, LLC , one ...
... for American Medical Innovation today applauded President Obama,s appointment ... National Institutes of Health (NIH). , , (Logo: ... , "Dr. Collins is both a friend to ... said Council President Dick Gephardt. "His passion and understanding ...
... CHICAGO, July 10 Fundamental American freedoms suffered a ... rule of the Washington Board of Pharmacy took precedence over individual ... Stormans v. Selecky , overturning a lower-court decision blocking a ... Washington will now be forced to provide RU-486 (the abortion pill), ...
... Physicians for Human Rights (PHR) has ... a major New York Times story with ... investigations into alleged war crimes in Afghanistan in 2002. , ... why the Bush Administration impeded an FBI criminal probe of the ...
Cached Medicine News:Health News:NOSCAR(R) Increases NOTES(R) Research with Olympus Medical Systems Corporation Grant 2Health News:NOSCAR(R) Increases NOTES(R) Research with Olympus Medical Systems Corporation Grant 3Health News:NOSCAR(R) Increases NOTES(R) Research with Olympus Medical Systems Corporation Grant 4Health News:UK Smoking Ban Fuels Rise In Surgery 2Health News:Healthy Directions, LLC Welcomes Jim Barch as New Chief Executive Officer 2Health News:Healthy Directions, LLC Welcomes Jim Barch as New Chief Executive Officer 3Health News:Council for American Medical Innovation Applauds Appointment of Geneticist Francis Collins to Head National Institutes of Health 2Health News:Americans United for Life: Ninth Circuit Ruling on Pharmacists Endangers Fundamental Freedoms 2Health News:New Evidence that Bush Administration Impeded 3 Investigations into Alleged Massacre of Up to 2,000 Prisoners in Afghanistan 2Health News:New Evidence that Bush Administration Impeded 3 Investigations into Alleged Massacre of Up to 2,000 Prisoners in Afghanistan 3Health News:New Evidence that Bush Administration Impeded 3 Investigations into Alleged Massacre of Up to 2,000 Prisoners in Afghanistan 4
(Date:12/15/2014)... 2014 As medical device manufacturers join pharmaceutical ... language standard, content teams have a greater role to ... with the standard. Starting January 2015, Data Conversion Laboratory ... the benefits and the critical aspects of implementing SPL. ... by Howard Shatz , DCL,s SPL expert, and ...
(Date:12/15/2014)...   DaVita HealthCare Partners Inc.  (NYSE: ... and most innovative health care communities, today announced ... Clinical Research  (DCR) and  HealthCare Partners Clinical Research , ... clinical research and data analytics services, specifically in ... renal disease (ESRD), as well as primary care ...
(Date:12/15/2014)... BOSTON , December 15, 2014 ... discovery and development company, is pleased to announce the ... United States relating to its GPCR-focused drug ... US significantly strengthens the global patent estate covering Heptares, ... The suite of patents recently granted by the ...
Breaking Medicine Technology:Data Conversion Laboratory Helping Life Sciences Content Producers Understand the Impact and Benefits of Structured Product Labeling 2Data Conversion Laboratory Helping Life Sciences Content Producers Understand the Impact and Benefits of Structured Product Labeling 3DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 2DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 3DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 4Heptares Extends Global Patent Protection for GPCR-Focused Drug Discovery Platform With Grant of Core Patents in the United States 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: