Navigation Links
Researchers detail possible resistance mechanisms of colorectal cancer to bevacizumab (Avastin)
Date:10/28/2013

A University of Colorado Cancer Center study published in the journal PLOS ONE shows that when colorectal cancer is targeted by the drug bevacizumab (Avastin), tumors may switch dependence from VEGF-A, which is targeted by the drug, to related growth factors in including VEGF-C, VEGF-D and placental growth factor. This change to new growth-factor dependence may allow colorectal cancer to push past bevacizumab's blockage of VEGF-A to continue to drive tumor growth.

"Think of it like damming a river. Bevacizumab can block the main flow, but then once a tumor's need builds up behind this dam, water starts to flow around the blockage in the form of streams and tributaries. That's like these other growth factors eventually a tumor becomes able to use these tributaries of VEGF-C, VEGF-D and placental growth factor to supply itself with the 'water' it needs," says Christopher Lieu, MD, investigator at the CU Cancer Center and assistant professor of Medical Oncology at the University of Colorado School of Medicine.

The analogy of liquid is an apt one bevacizumab slows cancer's growth by limiting a tumor's ability to grow the new blood vessels it needs to supply itself with nutrients. Especially in combination with chemotherapy, bevacizumab has proved an effective treatment for colorectal cancer. But then there frequently comes a point at which bevacizumab stops working and the tumor restarts its growth. This study asked why.

Specifically, Lieu and colleagues serially tested the levels of other VEGF-related growth factors in 42 patients treated with bevacizumab and chemotherapy, at many points during the course of their treatment.

"What we saw is that levels of VEGF-C and placental growth factor went up just before tumors progressed and then stayed high during the periods of tumor growth. Interestingly, VEGF-D was only elevated during progression. But it seems that tumors may be using these growth factors as ways to create bl
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Carnegie Mellon and University at Buffalo researchers improving transit for people with disabilities
2. Researchers discover a new protein fold with a transport tunnel
3. Mount Sinai Researchers Identify Mechanisms and Potential Biomarkers of Tumor Cell Dormancy
4. Study by researchers at Saarland University demonstrates preventive effect of sterols in Alzheimers
5. Neurotoxin effectively relieves bone cancer pain in dogs, Penn researchers find
6. Mount Sinai Researchers Find Value -- and Limitations -- of Patient Assistance Programs for Women with Breast Cancer
7. Researchers propose social network modeling to fight hospital infections
8. BUSM researchers make a case for free fatty acids
9. Researchers launch first-ever phase II safety study of rectal microbicide to prevent HIV
10. CWRU researchers probe brain implant failure and countermeasure
11. Researchers identify traffic cop for meiosis--with implications for fertility and birth defects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/29/2015)... ... June 29, 2015 , ... Brittenford Systems, a ... and other growing businesses across the United States, has announced that it has ... the fifth consecutive year. , Based on company revenue and number of employees, ...
(Date:6/29/2015)... Church, VA (PRWEB) , ... June 29, 2015 ... ... Optimizing Interaction with Medical Devices , **FDAnews Webinar**, July 16, 2015 — 1:30 ... manufacturers to help ensure the application of human factors engineering to the design ...
(Date:6/29/2015)... ... ... across the country give their coworkers and families gifts all the time. From holiday exchanges ... often do coworkers donate “life” to the husband of a coworker? For one VA employee, ... told me her husband was on a donor list,” Glenshaw resident Kathi Dahl said. “I ...
(Date:6/29/2015)... ... June 29, 2015 , ... Two multicounty ... C.R. Bard, Inc. and Ethicon, Inc. continue to move forward in New Jersey’s ... Conference is to be convened on Thursday, July 23rd at 12:00 p.m. (In ...
(Date:6/29/2015)... (PRWEB) , ... June 29, 2015 , ... ... to healthcare providers for patients with certain neuropsychiatric and chronic pain conditions, has ... and CEO. , The appointments include: Peter Donato, Senior Vice President, Chief Financial ...
Breaking Medicine News(10 mins):Health News:Brittenford Systems Celebrates Fifth Consecutive Year on Bob Scott Insights Top 100 VARs 2Health News:Brittenford Systems Celebrates Fifth Consecutive Year on Bob Scott Insights Top 100 VARs 3Health News:FDAnews Announces Human Factors and Usability Studies: Understanding and Optimizing Interaction with Medical Devices Webinar, July 16, 2015 2Health News:FDAnews Announces Human Factors and Usability Studies: Understanding and Optimizing Interaction with Medical Devices Webinar, July 16, 2015 3Health News:VA Pittsburgh Employee Donates Kidney to Coworker’s Spouse 2Health News:Transvaginal Mesh Lawsuit News: New Jersey Court Overseeing Thousands of Ethicon, C.R. Bard Pelvic Mesh Claims Schedules July Conference 2Health News:Transvaginal Mesh Lawsuit News: New Jersey Court Overseeing Thousands of Ethicon, C.R. Bard Pelvic Mesh Claims Schedules July Conference 3Health News:Transvaginal Mesh Lawsuit News: New Jersey Court Overseeing Thousands of Ethicon, C.R. Bard Pelvic Mesh Claims Schedules July Conference 4Health News:Assurex Health Names Executives to Posts as CFO, CMO and VP/Clinical Operations 2Health News:Assurex Health Names Executives to Posts as CFO, CMO and VP/Clinical Operations 3
... a bewildering array of regulatory DNA sequences interacting with a ... which genes are active when and where. Understanding how ... past decades but we are now starting to make significant ... how the entire complexity evolves to give differences in the ...
... giving up smoking after a programme involving sending motivational and ... months. , The findings of the txt2stop trial, which was ... and funded by the Medical Research Council, are published in ... innovative approach to the deadly problem of smoking, which is ...
... Current or heavy smokers who were screened with low-dose spiral ... deaths from lung cancer than did those who were screened ... clinical trial that involved more than 53,000 people. The ... in individuals at high risk of developing lung cancer to ...
... 29, 2011) A new treatment option may soon ... published in the July issue of The Journal ... that combined positron emission tomography and X-ray computed tomography ... refractory or relapsed high-risk neuroblastoma for treatment with a ...
... News) -- A new study reveals that 90 percent of ... started smoking, drinking or using drugs before they were 18 ... Americans who began using any addictive substance before age 18 ... using an addictive substance when they were 21 or older. ...
... cancer has provided the most comprehensive and integrated view of ... adenocarcinoma tumors from 500 patients were examined by The Cancer ... the June 30, 2011, issue of Nature . ... cancer, accounting for about 85 percent of all ovarian cancer ...
Cached Medicine News:Health News:Many a mickle makes a muckle: How changes in animals' size and shape arise 2Health News:Text message support for smokers doubles quit rates 2Health News:Screening with low-dose spiral CT scanning reduces lung cancer deaths by 20 percent 2Health News:Screening with low-dose spiral CT scanning reduces lung cancer deaths by 20 percent 3Health News:New therapy for childhood neuroblastoma proves feasible and safe 2Health News:Addiction Starts Early in American Society, Report Finds 2Health News:Addiction Starts Early in American Society, Report Finds 3Health News:The Cancer Genome Atlas completes detailed ovarian cancer analysis 2Health News:The Cancer Genome Atlas completes detailed ovarian cancer analysis 3
(Date:6/29/2015)... SAN FRANCISCO , June 29, ... company,s novel blood-draw technology has received CE Mark ... quality from the European Union. This regulatory milestone ... alternative to one of the most common procedures ... Velano Vascular,s proprietary device reduces the ...
(Date:6/29/2015)... , June 29, 2015 ... and predicted revenues ,Where is the market for dermatological ... market? Visiongain ,s new report shows you potential ... and prospects. Our 310 page report ... most lucrative areas in the industry and the future ...
(Date:6/29/2015)... Calif. , June 29, 2015  The ... innovative features to cars on the basis of ... The industry is now on the verge of ... cars. While automotive HWW non-critical features such as ... be present in 30 to 40 percent of ...
Breaking Medicine Technology:Velano Vascular Receives CE Mark For Novel Blood Draw Technology Designed to Reduce Needle Exposures for Hospitalized Patients and Healthcare Providers 2Dermatological Drugs Market Forecast 2015-2025 Opportunities for Leading Companies 2Dermatological Drugs Market Forecast 2015-2025 Opportunities for Leading Companies 3Dermatological Drugs Market Forecast 2015-2025 Opportunities for Leading Companies 4Dermatological Drugs Market Forecast 2015-2025 Opportunities for Leading Companies 5Dermatological Drugs Market Forecast 2015-2025 Opportunities for Leading Companies 6Dermatological Drugs Market Forecast 2015-2025 Opportunities for Leading Companies 7Dermatological Drugs Market Forecast 2015-2025 Opportunities for Leading Companies 8Convergence Trends See the Automotive Industry Integrate Health, Wellness and Wellbeing into Vehicles 2Convergence Trends See the Automotive Industry Integrate Health, Wellness and Wellbeing into Vehicles 3Convergence Trends See the Automotive Industry Integrate Health, Wellness and Wellbeing into Vehicles 4
... Expected in November 2008, BOTHELL, Wash., Oct. 9 ... the completion of patient enrollment and dosing,for the third ... and,efficacy of its formulation of 12-hour extended-release (ER) ibuprofen ... top-line,results from this pivotal trial in November 2008. Ibuprofen ...
... Will Reduce Animal Use in Cosmetics and Chemicals ... Corp. today announced,that results of a recently completed ... EpiDerm in vitro human skin tissue,equivalent. The test ... to be accepted as a validated alternative to ...
Cached Medicine Technology:SCOLR Pharma Announces Completion of Patient Enrollment and Dosing for Pivotal Clinical Trial Evaluating Extended Release Ibuprofen 2SCOLR Pharma Announces Completion of Patient Enrollment and Dosing for Pivotal Clinical Trial Evaluating Extended Release Ibuprofen 3MatTek's EpiDerm In Vitro Tissues Headed for Validation in Europe 2
... A concentrated enzymatic cleanser ... semi-automated hematology instruments. It ... all Abbott CELL-DYN® hematology ... instruments. The shelf life ...
Streck-CD3500 Hemoglobin/Lyse is a lytic reagent for the quantitative determination of hemoglobin on the Abbott CELL-DYN® 3500 and 3700. The shelf life is two years from the date of manufacture....
Streck-Diluent III Plus is a balanced electrolyte solution manufactured specifically for use as a diluent for blood cell counting and sizing on the Abbott CELL-DYN® 3000, 3500 and 3700. The shelf...
Streck-Diluent IIIA is a balanced electrolyte solution manufactured specifically for use as a diluent for blood cell counting and sizing on the Abbott CELL-DYN® 1700. The shelf life is one year f...
Medicine Products: