Navigation Links
Researchers describe mechanisms by which capon gene causes heart rhythm disturbances
Date:3/3/2008

LOS ANGELES (EMBARGOED UNTIL MARCH 3, 2008, AT 5 P.M. EST) A research team from the Cedars-Sinai Heart Institute, Johns Hopkins University and China Medical University and Hospital in Taiwan have described for the first time the mechanisms by which variants of a specific gene, CAPON or NOS1AP, can disrupt normal heart rhythm. Until recently, CAPON was not even suspected of existing in heart tissue or playing a role in heart function.

The study, conducted in guinea pigs, confirms that CAPON naturally exists in the ventricles (pumping chambers) of the heart. The researchers show that CAPON interacts with a signaling molecule (NOS1) in heart muscle to influence signaling pathways and modify cell-to-cell interactions (calcium ion and potassium ion channels) that control electrical currents.

Eduardo Marbn, M.D., Ph.D., director of the Cedars-Sinai Heart Institute, is senior author of an article, published online March 4 in Proceedings of the National Academy of Sciences (Early Edition), that fully describes these events.

The effects of CAPON and its variants are seen in the QT interval of EKGs, which reflect electrical activity from the time the ventricles are stimulated to the end of the heart muscle activity in a single heartbeat. Whether too long or too short, QT interval abnormalities can represent serious heart rhythm problems, including the risk of sudden death.

Long- and short-QT syndromes can be caused by rare congenital disorders that affect the ion channels, but most deaths caused by sudden arrhythmias occur in people who do not have these genetic mutations. Until recently, physicians and researchers were unable to explain the basis of QT interval abnormalities in otherwise healthy people.

In 2006, however, Marbn was among researchers who used a new approach to gene discovery to search for genetic influences on QT interval variations. From a general population which has been extensively studied (the KORA Cohor
'/>"/>

Contact: Sandy Van
sandy@prpacific.com
800-880-2397
Cedars-Sinai Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/27/2014)... MN (PRWEB) November 27, 2014 ... of office ergonomics equipment , has announced that ... with Commercial Office Environments. The partnership will put ... office furnishings location. , In addition to having ... new dealer partnership promotes HealthPostures' products with the ...
(Date:11/27/2014)... Allowing children to help with chores while ... give children responsibility, ownership, boosts self-esteem, and above all, helps ... the real question is, how do you encourage your children ... a study published by Child Development Journal, there is. The ... on a child’s willingness to lend a hand. , ...
(Date:11/27/2014)... (PRWEB) November 27, 2014 "The uglier, the ... month of December is full of laughter as we enjoy ... won by making a sweater from scratch. " It was ... tree, and if that weren't ridiculous enough, the Christmas balls ... , For those interested in participating this year, it's ...
(Date:11/27/2014)... Ethane Web Technologies, which is an ... reputation management service. , The company has designed ... world of internet marketing and algorithms of major search ... Web Technologies does not work with the same strategy ... to reach a conclusion what will work for the ...
(Date:11/27/2014)... (PRWEB) November 27, 2014 Ethane Web Technologies, ... it will provide a 10% Christmas discount on PPC service. ... December. The discount offer will begin on 1 December 2014 ... , About this offer, a PPC professional working at Ethane ... especially for small businesses, as this big discount would make ...
Breaking Medicine News(10 mins):Health News:Ergonomics Manufacturer Announces New Partnership with Office Supply Dealer 2Health News:Verde Pointe Dental Associates Hosts 2014 Ugly Holiday Sweater Contest 2Health News:Verde Pointe Dental Associates Hosts 2014 Ugly Holiday Sweater Contest 3Health News:Ethane Web Technologies Announces Online Reputation Management Service 2Health News:Ethane Web Technologies Announces 10% Christmas Discount on PPC Service 2
... Respiratory Distress Syndrome is a severe injury to most or ... of breath and often are on life support. //A new ... of developing ARDS after a trauma. ,ARDS is not ... is associated with a number of diseases including pneumonia, shock, ...
... adults who had very low birth weights are likely ... than others born at higher birth rates. //The study, ... Australia, reports respiratory function is more drastically reduced with ... individuals with low birth weight, defined as weighing less ...
... the outbreak earlier this year, the next time the ... health systems, //says a report by the National Intelligence ... of SARS transmission of were stopped, the virus could ... humans, the report says. ,"The wave of severe ...
... have long known that kidney failure is a complication ... types of transplants are most likely to lead to ... Ann Arbor, report patients who have intestine transplants are ... who receive heart-lung transplants. ,Doctors studied more than ...
... Australian researchers say a swimming pool could improve the ... world.// ,The researchers believe these findings hold important ... such as those measured in their study are a ... fever. ,Investigators studied children under age 17 in ...
... for diabetic patients with severe foot ulcers.// Chronic foot ulcers ... one of the most expensive diabetic complications. This common complication ... A new study led by investigators from Karolinska Hospital in ... foot ulcers in diabetic patients. ,For the study, 87 ...
Cached Medicine News:Health News:Return of SARS possible this fall 2
(Date:11/26/2014)... The medical magnetic resonance imaging (MRI) ... with world market revenues for 2013 at $5.1 ... types of medical imaging have led to improvements ... conditions in children and adults, each imaging procedure ... Medical Imaging Markets , analyzes the current and ...
(Date:11/26/2014)...  At the American Dental Association,s Annual Meeting in ... Kerr Group was honored to be part of the ... to see and test the Best of Class winners ... on the latest developments in dental technology. This year, ... CariVu Caries Detection Device and Kerr Demi ™  ...
(Date:11/26/2014)... YORK , Nov. 25, 2014  Medtronic,s ... Covidien has been widely discussed in the ... it,s also creating a stronger leading player in ... to Kalorama Information.  The healthcare market research firm ... systems will feature a diverse set of solutions ...
Breaking Medicine Technology:Kalorama: Steady Growth in the Medical MRI Market 2Kalorama: Steady Growth in the Medical MRI Market 3KaVo Kerr Group Showcased in Pride Institute Technology Expo at ADA Annual Meeting 2KaVo Kerr Group Showcased in Pride Institute Technology Expo at ADA Annual Meeting 3Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 2Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 3
... 4, 2012 Watson Pharmaceuticals, Inc. (NYSE: WPI ... Paul Bisaro, Watson,s President and Chief Executive Officer, will provide ... Bank of America Merrill Lynch 2012 Healthcare Conference on Wednesday, ... Encore at the Wynn in Las Vegas, Nevada. The presentation ...
... 4, 2012 To the delight of shoppers and pet ... program that provides customers convenient access and savings for prescription ... health of their pets. More than 60 percent ... more than $50 billion on their pets in 2011 alone(ii), ...
Cached Medicine Technology:Watson to Present at the Bank of America Merrill Lynch 2012 Health Care Conference 2Kmart® Launches New Pet Prescription Program And Purina® Treat Giveaway 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: