Navigation Links
Researchers describe how chronic inflammation can lead to stomach cancer
Date:11/5/2008

NEW YORK A multi-center research team, led by Columbia University Medical Center, has uncovered a major contributor to the cause of stomach cancer the second leading cause of cancer-related mortality in the world. The team described for the first time, that elevated levels of a single proinflammatory cytokine, an immune system protein called interleukin-1 beta (IL-1β), can start the progression towards stomach cancer. These results are published in the Nov. 4, 2008 issue of Cancer Cell. The researchers hope to use this finding to develop ways to block this process, thereby preventing cancer from developing.

"This study shows that accumulation of IL-1β, which is induced by infection with the bacterium Helicobacter pylori (H. pylori) in the gastrointestinal tract, is a significant contributor to the onset of stomach cancer," said lead author Timothy C. Wang, M.D., chief of the Division of Digestive and Liver Diseases and the Dorothy L. and Daniel H. Silberberg Professor of Medicine at Columbia University College of Physicians and Surgeons. "We show in this study that IL-1β works by activating a type of white blood cell known as myeloid derived suppressor cells (MDSCs), which in our study appeared to be strongly pro-inflammatory. Blocking IL-1β or the myeloid (MDSCs) cells may represent a potential strategy to prevent stomach cancer."

Previous research has shown that stomach cancer is strongly linked to chronic inflammation, and that infection with H. pylori may trigger the chronic inflammation that can lead to malignancy, but it was not known exactly how. While H. pylori infection is extremely prevalent, only a small minority (less than one percent) of infected individuals will, after many years, go onto develop stomach cancer. Previous research had linked H. pylori infection to the overexpression of IL-1β, and the susceptibility to gastric cancer to high-expressing IL-1 ge
'/>"/>

Contact: Elizabeth Streich
eas2125@columbia.edu
212-305-6535
Columbia University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers ID Genetic Markers for Esophageal Cancer
2. Researchers identify mechanism, possible drug treatment for tumors in neurofibromatosis
3. Cancer requires support from immune system to develop, UT Southwestern researchers report
4. Researchers find new chemical key that could unlock hundreds of new antibiotics
5. Penn researchers find key to Sonic hedgehog control of brain development
6. Temple researchers look for behavioral link between breastfeeding and lower risk of obesity
7. MU researchers advance health communication for at-risk populations
8. Researchers Find More Genes Linked to Lung Cancer
9. Researchers estimate lives lost due to delay in antiretroviral drug use for HIV/AIDS in South Africa
10. Georgetown University Med Center reproductive health researchers tackle public health concerns
11. Stem-cell sentry sounds the alarm to maintain balance between cancer and aging, U-M researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... 2015 , ... The Mount Sinai Health System will work with Columbia Care ... related, experimental treatments. The collaboration moves into the next phase with the recent decision ... five state licenses to produce and dispense medical marijuana. , Mount Sinai and ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... BioViva USA, ... the way we treat aging diseases. , BioViva announces it has begun a ... patients with Alzheimer’s Disease (AD) and find a cure. MaxLife will grant 100% of ...
(Date:7/31/2015)... Toledo, Ohio (PRWEB) , ... July 31, 2015 ... ... U.S. District Court for the Northern District of Ohio, Western Division (Case No. ... complaint (Case No: 3:15-cv-00397), the women experienced spontaneous migration of their Implanon® implants, ...
(Date:7/31/2015)... ... 2015 , ... The Heart Fit Clinic has increased a patient's fitness level ... of 150 beats versus 100 beats, this is a big deal," says Diamond Fernandes, ... back to patients with heart disease," he adds. People with angina are able to ...
(Date:7/31/2015)... ... 31, 2015 , ... Florida Hospital Tampa has started treating ... for targeted delivery of fluids to selected sites in the peripheral vascular system. ... with the device that provides direct, local delivery of chemotherapy to the pancreas. ...
Breaking Medicine News(10 mins):Health News:Mount Sinai to Collaborate with Columbia Care on Medical Marijuana Research 2Health News:Mount Sinai to Collaborate with Columbia Care on Medical Marijuana Research 3Health News:BioViva USA, Inc.’s Alzheimer’s Disease Gene Therapy Human Trial 2Health News:BioViva USA, Inc.’s Alzheimer’s Disease Gene Therapy Human Trial 3Health News:Can Implanon® (Etonogestrel Implant) Go Missing? Zoll, Kranz & Borgess, LLC Files Another Lawsuit on Behalf of Women with Lost or Migrated Implanon® Implants 2Health News:Can Implanon® (Etonogestrel Implant) Go Missing? Zoll, Kranz & Borgess, LLC Files Another Lawsuit on Behalf of Women with Lost or Migrated Implanon® Implants 3Health News:Heart Fit Clinic Helps Patient Increase Fitness Level with External Counterpulsation 2Health News:Florida Hospital Tampa Expands Treatment Options for Patients with Pancreatic Cancer Using New Catheter Technology 2Health News:Florida Hospital Tampa Expands Treatment Options for Patients with Pancreatic Cancer Using New Catheter Technology 3Health News:Florida Hospital Tampa Expands Treatment Options for Patients with Pancreatic Cancer Using New Catheter Technology 4
... authored by two Memorial University faculty members published in ... the Public Library// of// Science (PLoS). Drs. Amin A. ... the paper, entitled, "Prevalence of depression among house holds ... the mental health policy." ,Dr. Muhammad Gadit ...
... allow a pioneering doctor, currently under house arrest in Henan ... award for her work on behalf// of HIV/AIDS patients, it ... had permission to travel," retired professor Gao Yaojie, 79, told ... holding her under house arrest for two weeks. ...
... found supporting evidence to implicate insulin-like growth factor receptor ... ,In a previous research, Terry J. Smith, M.D. and ... immunoglobulins and IGF-1R as a cause of inflammation and ... , The discovery of these mechanisms in ...
... University have developed a novel spraying method for delivering ... a new low-cost and scaleable technique that offers needle-free ... methods. The process could one day provide a better ... related spread of HIV/AIDS in the developing world. ...
... If you are cooking with garlic, crush the pods first ... benefits and medicinal properties are well known. It has long ... folklore for preventing everything from the common cold and flu ... herbal medicine and it contains compounds shown to help prevent ...
... on Friday plan to distribute 250,000 city-branded condoms as ... the spread of HIV// and other sexually transmitted infections, ... purple and yellow package is printed in English and ... Coming together to stop HIV in D.C.' The first ...
Cached Medicine News:Health News:A Single Biological Mechanism Behind Several Autoimmune Disorders 2Health News:Scientists Partner to Develop and Distribute New Tuberculosis Vaccine 2Health News:Free Condoms Distribution to Prevent HIV in Washington 2
(Date:7/31/2015)... CHAPEL HILL, N.C. , July 31, 2015 ... to product success in the biopharmaceutical market. Patients ... the process of selecting and switching therapies. This ... and is pushing marketers, efforts toward patient-focused marketing. ... to patient engagement, marketers have learned it,s important ...
(Date:7/31/2015)... July 31, 2015  In today,s ever-changing marketplace, call ... increasingly mobile, increasingly connected, and increasingly impatient with slow ... customer interaction channels and tools is driving call centers ... According to research by benchmarking firm, ... (OTC) segment in a call center study realize the ...
(Date:7/31/2015)... 31, 2015  Seeger Weiss LLP is reporting that on ... warning letter to C.R. Bard, the manufacturer of Inferior ... to correct violations the agency found at two of Bard,s ... the FDA cited them during Inspectional Observations that occurred on ... Tempe, AZ , location and on October 6, ...
Breaking Medicine Technology:Consumers Forcing Pharmaceutical Industry to Shift its Marketing Focus from Products to Patients 2Best Practices in Building World-Class Consumer & Over-the-Counter Call Centers 2Seeger Weiss LLP Reports That The FDA Has Issued A Warning Letter To IVC Filter Manufacturer, C.R. Bard 2Seeger Weiss LLP Reports That The FDA Has Issued A Warning Letter To IVC Filter Manufacturer, C.R. Bard 3
... 20, 2011 Sevocity, a division of Conceptual MindWorks, ... selected by CITIA-SC as a preferred electronic health record ... Sevocity is the leading true Internet or cloud-based EHR. ... and customizable electronic health record system with low start-up ...
... 2011 Concentric Medical, Inc., the global leader in ... announced the launch of the expanded family of Merci ... 2.0 Soft and V 3.0 Soft, through recent Ichihen ... are now approved and reimbursed in Japan.  The Merci ...
Cached Medicine Technology:Sevocity® Named Preferred EHR Vendor by CITIA-SC, South Carolina's Health IT Regional Extension Center (REC) 2Concentric Medical Launches Full Family of Merci Retrievers® in Japan 2Concentric Medical Launches Full Family of Merci Retrievers® in Japan 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: