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Researchers describe a new genetic program that converts static cells into mobile invasive cells
Date:12/15/2011

Researchers at the Institute for Research in Biomedicine (IRB Barcelona) have identified the gene GATA 6 as responsible for epithelial cells -which group together and are static- losing adhesion and moving towards a new site. This process, which is common to developing organisms, is very similar to one that occurs in metastasis, when tumour cells escape from the original tumour and invade new tissue. "This process explains why Gata 6 is found in cancers of the liver, pancreas and colon, thus allowing tumour cells to acquire metastatic properties", stresses Jordi Casanova, CSIC professor and head of the Drosophila Morphogenesis Group at IRB Barcelona, where the study has been conducted. The journal Developmental Cell is to publish the results of this study this week.

In addition, Gata 6 triggers a genetic programme that favours the survival and adaptation of cells in new tissue. It also promotes the expression of some enzymes, the so-called metalloproteases, which degrade the cellular matrix, thus allowing cells to migrate and enter new tissue. Furthermore, Gata 6 induces the gene Forkhead, which is a survival factor. "When cells start migrating they are subjected to many changes and to stress, and in these adverse conditions many can die. This gene protects them against death", explains Kira Campbell, "Juan de la Cierva" post-doctoral fellow with Casanova's lab and first author of the article. Tumour cells hold metalloproteases and Forkhead.

From the Drosophila fly to cancer

Once again the small fly D. melanogaster, used in developmental studies, has shed light on processes linked to cancer. Casanova's team, which specializes in morphogenesis, has revealed the mechanism by which epithelial cells transform into mesenchymatic cells during gut development in fly embryos. The Drosophila gut is an endodermal organ, as is the colon, the liver and the pancreas. "What we have discovered is that the progra
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Contact: Snia Armengou
sonia.armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert  

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