Navigation Links
Researchers demonstrate that 'safe' cigarettes are as hazardous as tobacco
Date:5/12/2010

Using the same technique they developed to document the harmful effects of tobacco products, a team of researchers found that cigarettes made without tobacco or nicotine may be more carcinogenic because they actually induce more extensive DNA damage than tobacco products. The technique has been awarded U.S. patent No. 7,662,565.

The research team was led by Zbigniew Darzynkiewicz, M.D., Ph.D., professor of pathology. Their study, "DNA damage response induced by exposure of human lung adenocarcinoma cells to smoke from tobacco- and nicotine-free cigarettes," will appear in the June 1 issue of Cell Cycle (Volume 9, Issue 11).

Using laser scanning cytometry (LSC) technology to measure DNA damage response to the smoke from commercially available tobacco- and nicotine-free cigarettes, the research team expected to find the alternative products were less hazardous than regular tobacco cigarettes. However, their data suggest that exposure of cells to smoke from tobacco- and nicotine-free cigarettes leads to formation of double-strand DNA breaks (DSBs). Since DSBs are potentially carcinogenic, the data indicate that smoking tobacco- and nicotine-free cigarettes is at least as hazardous as those containing tobacco and nicotine.

The authors conclude that their methodology to assess the potential carcinogenic properties of tobacco smoke, based on measurement of DNA damage response as assessed by LSC, provides a useful addition to the battery of genotoxic tests for probing cigarette smoke hazards. Such tests, which can be applied to evaluate the effects of cigarettes and cigarette surrogate products on human health, can be important tools for regulatory agencies such as the Food and Drug Administration or, in the case of environmental smoke, by the Environmental Protection Agency.


'/>"/>

Contact: Donna E. Moriarty
donna_moriarty@nymc.edu
914-594-4536
New York Medical College
Source:Eurekalert

Page: 1

Related medicine news :

1. UCSF Researchers Identify Regulator of Human Sperm Cells
2. Researchers find broad spectrum antiviral that fights multitude of viruses
3. University of Alberta researchers develop drug interface to save lives
4. Caregivers of ICU patients are collateral damage of critical illness, say Pitt researchers
5. Researchers fight world hunger by mapping the soybean genome
6. HIV researchers solve key puzzle after 20 years of trying
7. UC Davis researchers identify brain protein for synapse development
8. UCLA cancer researchers perform complete genomic sequencing of brain cancer cell line
9. Researchers find new way to study how enzymes repair DNA damage
10. UCLA researchers image earliest signs of Alzheimers, before symptoms appear
11. Researchers find leukemia cells metabolize fat to avoid cell death
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2016)... ... ... "With 30 unique self-animating web themed intros and complete control over customization, ... Christina Austin - CEO of Pixel Film Studios. , ProIntro Web Volume 3 ... Cut Pro X. Pixel Film Studios’ minimalistic titles allow users to add a sleek ...
(Date:5/28/2016)... ... May 28, 2016 , ... May 26, 2016- In search of the ... with theme event of “K Warriors” on June 4, 2016 at Ashbury Hotel and ... event is sponsored and hosted by Shaolin Institute and sanctioned by KSF (Kungfu Sanda ...
(Date:5/27/2016)... ... May 27, 2016 , ... More than a third of American adults are ... bariatric surgery has received increased attention in recent years, as an article ... to weight loss, most people are familiar with the basic requirements of maintaining a ...
(Date:5/27/2016)... , ... May 27, 2016 , ... W.S. Badger ... announced today that it has been recognized as one of the best small businesses ... was named as one of nine small businesses providing progressive benefits to new parents ...
(Date:5/27/2016)... New York, NY (PRWEB) , ... May 27, 2016 , ... ... the factors of a stroke, which we as a society can control and change. ... a stroke occurs nearly every 40 seconds within the United States. Plus, with an ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... FDA 510(k) clearance covers Confocal Miniprobes ... and surgical applications Mauna Kea Technologies ... multidisciplinary confocal laser endomicroscopy (CLE) platform, today announced ... the 12 th 510(k) clearance from United ... FDA clearance covers Confocal Miniprobes indicated for use ...
(Date:5/25/2016)... , Germany and GERMANTOWN, ... QIAGEN N.V. (NASDAQ: QGEN ; Frankfurt Prime Standard: ... licensing and co-development agreement with Therawis Diagnostics GmbH to develop ... be to develop and market PITX2 as a marker to ... high-risk breast cancer patients. "We are pleased to ...
(Date:5/25/2016)... , May 25, 2016 ... Size, Share, Development, Growth and Demand Forecast to 2022 ... Insulin Pump and Others)" published by P&S Market Research, ... $9,998.3 million in 2015, and it is expected to ... on type, the insulin pump segment is expected to ...
Breaking Medicine Technology: