Navigation Links
Researchers decipher manic gene
Date:8/31/2012

Flying high, or down in the dumps - individuals suffering from bipolar disorder alternate between depressive and manic episodes. Researchers from the University of Bonn and the Central Institute of Mental Health in Mannheim have now discovered, based on patient data and animal models, how the NCAN gene results in the manic symptoms of bipolar disorder. The results have been published in the current issue of "The American Journal of Psychiatry."

Individuals with bipolar disorder are on an emotional rollercoaster. During depressive phases, they suffer from depression, diminished drive and often, also from suicidal thoughts. The manic episodes, however, are characterized by restlessness, euphoria, and delusions of grandeur. The genesis of this disease probably has both hereditary components as well as psychosocial environmental factors.

The NCAN gene plays a major part in how manias manifest

"It has been known that the NCAN gene plays an essential part in bipolar disorder," reports Prof. Dr. Markus M. Nthen, Director of the Institute of Human Genetics at the University of Bonn. "But until now, the functional connection has not been clear." In a large-scale study, researchers led by the University of Bonn and the Central Institute of Mental Health in Mannheim have now shown how the NCAN gene contributes to the genesis of mania. To do so, they evaluated the genetic data and the related descriptions of symptoms from 1218 patients with differing ratios between the manic and depressive components of bipolar disorder.

Comprehensive data from patients and animal models

Using the patients' detailed clinical data, the researchers tested statistically which of the symptoms are especially closely related to the NCAN gene. "Here it became obvious that the NCAN gene is very closely and quite specifically correlated with the manic symptoms," says Prof. Dr. Marcella Rietschel from the Central Institute of Menta
'/>"/>

Contact: Dr. Markus M. Nthen
markus.noethen@uni-bonn.de
0049-228-287-22347
University of Bonn
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Cleveland Clinic researchers investigating potential drug for treatment of Alzheimers disease
2. BUSM researchers study use of MRI in osteoarthritis
3. Wayne State researchers say adolescent smoking prevention programs still critical
4. WSU researchers discover mechanism leading from trichomoniasis to prostate cancer
5. URMC researchers connect new genetic signature to leukemia
6. Trudeau researchers identify unforeseen regulation of the anti-bacterial immune response
7. In war with superbugs, Cedars-Sinai researchers see new weapon: Immune-boosting vitamin
8. Midlife fitness staves off chronic disease at end of life, UT Southwestern researchers report
9. Moffitt Cancer Center researchers and colleagues identify PHF20, a regulator of gene P53
10. Cramming for a test? Dont do it, say UCLA researchers
11. Brigham and Womens Hospital researchers initiate major cardiovascular inflammation reduction trial
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... April 17, 2014 By discovering a new mechanism ... a stroke, researchers at UC Irvine and the Salk ... may limit or prevent stroke-induced brain damage. , A ... cause of death and primary reason for disability in ... a stroke and lets blood-borne material into the brain, ...
(Date:4/17/2014)... Cesar A. Arias, M.D., Ph.D., at The University of ... a new superbug that caused a bloodstream infection in ... 17 issue of The New England Journal of ... a class of highly-resistant bacteria known as methicillin-resistant ... cause of hospital and community-associated infections. The superbug has ...
(Date:4/17/2014)... than 40 years away from a food shortage that ... to a top scientist at the U.S. Agency for ... food production will be limited on a global scale ... Dr. Fred Davies, senior science advisor for the agency,s ... politically destabilizing by 2050 as energy issues are today.", ...
(Date:4/17/2014)... treatment that lost its status as the leading weapon ... lease of life, with new research indicating it simply ... revive the use of the cheap anti-malarial drug chloroquine ... the lives of more than half a million people ... causes malaria has developed resistance to chloroquine, but research ...
(Date:4/16/2014)... 2014) A team that includes scientists from the School ... at San Antonio, Johns Hopkins University and St. Mary,s University ... fungus to infect the body. , The fungal pathogen ... thrush, and is the most common fungal pathogen to infect ...
Breaking Medicine News(10 mins):Health News:Study IDs new cause of brain bleeding immediately after stroke 2Health News:New MRSA superbug emerges in Brazil 2Health News:Food shortages could be most critical world issue by mid-century 2Health News:Scientists find new way to fight malaria drug resistance 2
... its employees further strengthen community support by donating an ... giving campaign DUBLIN, Ohio, Feb. 18 The Cardinal ... $1.2 million to non-profit programs that seek to improve ... Cardinal Health has the highest concentration of employees. Over ...
... (Nasdaq: ALGN ) today announced that the Company ... against the Company on February 17, 2009 by ClearCorrect, Inc. ... of Texas. Align Technology became aware of the filing on ... copy of the Complaint.In the Complaint, assigned case # H-09-470 ...
... Who Use the OmniPod System to Manage their Diabetes , ... country,s top professional cross-country skiers, is competing on behalf of ... As a world-class athlete, Freeman intends to medal, but he ... Diabetes doesn,t keep Freeman from performing at the top ...
... from this trial supported entry into Company,s current ... -,BELLEVILLE, ON, Feb. 18 /PRNewswire-FirstCall/ - Bioniche Life ... biopharmaceutical company, today announced that The Journal of ... II clinical trial results for the Company,s proprietary ...
... Calif., Feb. 18 In a dramatic move ... direct care RN organizations, the,United American Nurses, California ... Association today announced,they are joining together to form ... The new organization will be called the ...
... of Hosted Microsoft Exchange, presents competitive risk-proof, out-of-the-box solution for resellers ... ... -- SherWeb , a global leader in hosted solutions ... last week. The newly implemented program provides IT solution providers with ...
Cached Medicine News:Health News:Cardinal Health Foundation Invests $1.2 Million in Local Non-Profit Programs That Improve Health in Key Employee Communities 2Health News:Cardinal Health Foundation Invests $1.2 Million in Local Non-Profit Programs That Improve Health in Key Employee Communities 3Health News:Cardinal Health Foundation Invests $1.2 Million in Local Non-Profit Programs That Improve Health in Key Employee Communities 4Health News:Cardinal Health Foundation Invests $1.2 Million in Local Non-Profit Programs That Improve Health in Key Employee Communities 5Health News:Align Technology Asserts ClearCorrect Complaint Is Without Merit 2Health News:Elite Skier Uses OmniPod(R) Insulin Management System at World Championships 2Health News:Bioniche Phase II Bladder Cancer Trial Results Published in The Journal of Urology 2Health News:Bioniche Phase II Bladder Cancer Trial Results Published in The Journal of Urology 3Health News:Bioniche Phase II Bladder Cancer Trial Results Published in The Journal of Urology 4Health News:SherWeb Launches Unique White Label Exchange Reseller Program 2
(Date:1/15/2014)... Jan. 15, 2014 Reportlinker.com announces that ... in its catalogue: ... and Market Analysis to 2022 ... Dermatitis - India Drug Forecast and Market ...
(Date:1/15/2014)... FRANKLIN, Ohio , Jan. 15, 2014  A novel wearable ... it easy and painless for patients to self-inject prescription drugs ... of disorders, including cancer, blood diseases, autoimmune deficiencies, and genetic ... expected to grow to $220B by 2018, according to analysts.   ...
(Date:1/14/2014)... Healthcare Services, Inc. ("DHS"), a portfolio company of GMH Ventures ... Equipment, Inc. ("Progressive") of Clarion, PA ... not disclosed. Progressive is a full service ... sleep, mobility, and respiratory products to customers in the western ...
Breaking Medicine Technology:PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 2PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 4PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 5Enable Injections Presents A New Class of Injectors for Drug Delivery at PEPTalk, Drug Delivery Partnership Meetings 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3
... 21, 2010 ... ... var shortURL = ... so we need to grab the first one. for (var r in data.results) { first_result = data.results[r]; ...
... Pharma L.P. announces the launch of its new pharmacy ... enforcement officials and loss prevention personnel can follow updates ... area and nationwide. The tweets provide safety and security ... protect customers and their businesses. Followers also receive notices ...
Cached Medicine Technology:immatics Raises EUR54 Million to Advance its Late Stage Clinical Therapeutic Cancer Vaccine Portfolio 2immatics Raises EUR54 Million to Advance its Late Stage Clinical Therapeutic Cancer Vaccine Portfolio 3immatics Raises EUR54 Million to Advance its Late Stage Clinical Therapeutic Cancer Vaccine Portfolio 4immatics Raises EUR54 Million to Advance its Late Stage Clinical Therapeutic Cancer Vaccine Portfolio 5immatics Raises EUR54 Million to Advance its Late Stage Clinical Therapeutic Cancer Vaccine Portfolio 6immatics Raises EUR54 Million to Advance its Late Stage Clinical Therapeutic Cancer Vaccine Portfolio 7immatics Raises EUR54 Million to Advance its Late Stage Clinical Therapeutic Cancer Vaccine Portfolio 8immatics Raises EUR54 Million to Advance its Late Stage Clinical Therapeutic Cancer Vaccine Portfolio 9immatics Raises EUR54 Million to Advance its Late Stage Clinical Therapeutic Cancer Vaccine Portfolio 10Twitter Provides New Way to Fight Pharmacy Crime 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: