Navigation Links
Researchers decipher blood stem cell attachment, communication
Date:3/25/2009

Researchers at the National Institutes of Health have deciphered a key sequence of events governing whether the stem cells that produce red and white blood cells remain anchored to the bone marrow, or migrate into the circulatory system.

An understanding of the factors that govern migration of blood stem cells might lead to improved treatment of leukemia, a cancer that affects circulating white blood cells. The findings also have implications for culturing infection-fighting immune cells outside the body, where they could be temporarily held in storage during chemotherapy and other treatments which suppress the immune system. Moreover, the findings could contribute to a strategy for growing large quantities of red blood cells in laboratory dishes outside the body, to reduce the need for blood donations.

Previously, researchers thought that the cellular environment in which the stem cells reside produced the chemical signals that determined whether the cells would be stationary or freefloating. The current study provides evidence that the stem cells produce chemical signals of their own that may, in turn, influence the chemical signals they receive from their environment.

"This important discovery will advance our understanding of how blood cells and immune cells are generated," said Duane Alexander, M.D., director of the NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).

The findings were published on line in Nature Cell Biology. The study was conducted in the laboratory of Jennifer Lippincott-Schwartz, Chief of the NICHD Section on Organelle Biology. The study's first author was Jennifer Gillette, also of the Section on Organelle Biology. Other authors were Andre Larochelle and Cynthia E. Dunbar of the Hematology Branch of NIH's National Heart, Lung, and Blood Institute.

Dr. Gillette explained that hematopoetic progenitor stem cellsthe cells which give rise to
'/>"/>

Contact: Robert Bock
bockr@mail.nih.gov
301-496-5133
NIH/National Institute of Child Health and Human Development
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers studying hearing loss find auditory regions of the brain convert to the sense of touch
2. UIC researchers measure health effects of Chicagos waterways
3. Focus on treating malnutrition in cancer patients, researchers say
4. Researchers Suspect Genetic Link to COPD
5. Syracuse University researchers build a new surface material that resists biofilm growth
6. Researchers Use Gene to End High Blood Sugar in Mice
7. Penn researchers identify new protein important in breast cancer genes role in DNA repair
8. Fish health claims may cause more environmental harm than good: UBC-St. Michaels researchers
9. Researchers clone key sperm-binding proteins
10. Researchers find sustained improvement in health in Experience Corps tutors over 55
11. Researchers develop DNA patch for canine form of muscular dystrophy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... and young adults living near Sellafield or Dounreay since ... developing cancer according to research published in the ... from the Childhood Cancer Research Group at the University ... between 1963 and 2006 among those who were under ... No difference was found in cancer incidence from 1991-2006 ...
(Date:7/23/2014)... 2014 A new study has uncovered ... ( http://www.injurybeacon.com/power-morcellator/ ) during minimally invasive hysterectomies can ... woman’s body, Bernstein Liebhard LLP reports. The research, which ... the American Medical Association, looked at 36,000 women who ... U.S. hospitals from 2006 to 2012. Ninety-nine of the ...
(Date:7/23/2014)... patients if a suspicious skin lesion is painful or ... likely to be cancerous, according to a new study ... of Dermatology at Temple University School of Medicine. , ... on July 23, 2014, found that nearly 36. 9 ... while 28.2 percent involve pain. Non-melanoma skin cancers ...
(Date:7/23/2014)... -- Painful or itchy skin lesions could be a ... sometimes have multiple lesions that are suspicious looking, and ... concerns for non-melanoma skin cancers," study author Dr. Gil ... Medicine, said in a Temple University Health System news ... 268 patients who were confirmed to have skin cancer ...
(Date:7/23/2014)... Rich Dad® Education, a leader in financial education, is ... to support Habit for Humanity of Lee and Hendry Counties. ... be donated to Habitat for Humanity. Additionally, all the items ... Habitat for Humanity ReStore thrift store located at 31 Willis ... the highlights of the yard sale was a visit from ...
Breaking Medicine News(10 mins):Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Publication of New Study Confirming Potential for Uterine Morcellation to Spread Undetected Cancer 2Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Publication of New Study Confirming Potential for Uterine Morcellation to Spread Undetected Cancer 3Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Publication of New Study Confirming Potential for Uterine Morcellation to Spread Undetected Cancer 4Health News:Research led by Temple's chair of dermatology: Pain and itch may be signs of skin cancer 2Health News:Painful, Itchy Patches Could Be Sign of Skin Cancer 2Health News:Rich Dad Education Charity Yard Sale Raises Over $650 for Habitat for Humanity of Lee and Hendry Counties 2
... its smoking ban to entertainment outlets including pubs, nightclubs ... cut tobacco-related diseases. ,The ban will ... city-state which already has some of the toughest anti-smoking ... restrict smoking in entertainment outlets is a natural extension ...
... opportunity for superstition and marketing to come together: starry-eyed couples ... Earth concerts as well as the proclamation of the world's ... 7 has a magic sacred side and the reputation of ... bring an extra dose of good fortune. ,"Number ...
... Brahmachari and Dr. MRS Rao will be jointly awarded the ... 2005 for their outstanding contribution in the field of bio-medical ... one lakh. ,Besides, the Indian Council of Medical ... country to be honoured for their outstanding contributions in research ...
... prospective study suggests that ovarian germ cell tumour ... may retain their menstrual function and reproductive ... the Journal of Clinical Oncology, also found that ... more likely than their healthy counterparts to be ...
... a cure for smelly and pongy feet - special socks made ... eco-friendly sock to go on general sale, and experts have forecasted ... to take place in the world of clothing. ... of the silky material, which is softer, more durable and absorbent ...
... a slew of studies have highlighted the adverse effects of ... hours of gaming can actually be good for children. ... competing against each other give children a chance to learn ... and other races. ,The study by researchers from ...
Cached Medicine News:Health News:Singapore Extends Smoking Ban to Pubs, Nightclubs 2Health News:A Lucky Number? 7/7/07 2Health News:A Lucky Number? 7/7/07 3Health News:Survivors of Rare Ovarian Cancer may Retain Menstrual Function and Reproductive Ability 2Health News:Survivors of Rare Ovarian Cancer may Retain Menstrual Function and Reproductive Ability 3Health News:Exposure to Computer Games can Be 'good' for Kids, Says New Study 2
(Date:7/23/2014)... Creekridge Capital, an independent vendor-focused finance ... so far in 2014 to their portfolio of ... from both the healthcare and technology industries. They ... multi-national companies. Each of these new vendors take ... including: standard leasing products, subscription solutions, a dedicated ...
(Date:7/23/2014)... -- When it comes to welcoming our new robot overlords, InformationWeek ... the red carpet. Healthcare is one of the ... into our human sphere. With healthcare concerns top of mind ... apply new technologies to help with old problems. That,s where ... expected to increase from $1.7 billion now to $3.7 billion ...
(Date:7/23/2014)... 2014  Researchers from the North American Menopause Society ... calcium levels too high, 1 putting women at ... Women close to menopause are commonly told to ... diseases such as osteoporosis, to which they are particularly ... how much calcium they typically get through their food ...
Breaking Medicine Technology:Creekridge Capital Signs Several New Vendor Partners 2Women Taking Too Much Calcium Create Health Risk 2
... announces that a new market research report is ... Rheumatoid Arthritis (JRA) Therapeutics - Pipeline Assessment and ... http://www.reportlinker.com/p0479828/Juvenile-Rheumatoid-Arthritis-JRA-Therapeutics---Pipeline-Assessment-and-Market-Forecasts-to-2017.html Juvenile Rheumatoid Arthritis (JRA) ... 2017 Summary ...
... announces that a new market research report is ... Cancer Therapy Area Pipeline Report ... Therapy Area Pipeline Report contains detailed information on ... insight into the pipeline status of pancreatic cancer ...
Cached Medicine Technology:Reportlinker Adds Juvenile Rheumatoid Arthritis (JRA) Therapeutics - Pipeline Assessment and Market Forecasts to 2017 2Reportlinker Adds Juvenile Rheumatoid Arthritis (JRA) Therapeutics - Pipeline Assessment and Market Forecasts to 2017 3Reportlinker Adds Juvenile Rheumatoid Arthritis (JRA) Therapeutics - Pipeline Assessment and Market Forecasts to 2017 4Reportlinker Adds Juvenile Rheumatoid Arthritis (JRA) Therapeutics - Pipeline Assessment and Market Forecasts to 2017 5Reportlinker Adds Juvenile Rheumatoid Arthritis (JRA) Therapeutics - Pipeline Assessment and Market Forecasts to 2017 6Reportlinker Adds Juvenile Rheumatoid Arthritis (JRA) Therapeutics - Pipeline Assessment and Market Forecasts to 2017 7Reportlinker Adds Juvenile Rheumatoid Arthritis (JRA) Therapeutics - Pipeline Assessment and Market Forecasts to 2017 8Reportlinker Adds Pancreatic Cancer Therapy Area Pipeline Report 2Reportlinker Adds Pancreatic Cancer Therapy Area Pipeline Report 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: