Navigation Links
Researchers creating designer lymph nodes based on Moffitt's Total Cancer Care initiative
Date:4/27/2012

Researchers at Moffitt Cancer Center are in the first phase of creating "designer lymph nodes." Designer lymph nodes are built with specialized gene-modified cells that are injected into patients and produce a pre-planned immunologic response for cancer patients locally and then throughout their bodies. The researchers are examining a cancer vaccine "boosting" effect of the manufactured lymph nodes in patients with advanced melanoma.

"We used Moffitt's Total Cancer Care tissue biorepository, genomic database and longitudinal clinical database to identify the novel genes for creating designer lymph nodes," said James Mul, Ph.D., executive vice president and associate center director for Translational Research at Moffitt. "The gene signature is also associated with better patient prognosis and survival, and will also be used to pre-select patients for immunotherapy interventions."

The work, funded by a five-year, $2 million National Cancer Institute grant (RO1CA148995) as well as by the Adelson Medical Research and V Foundations, is in collaboration with researchers at Scripps Florida in Jupiter, Fla. Researchers at Scripps are using high-throughput screening technologies to rapidly identify biologic functions of the candidate genes.

"Patients with cancer have a dysfunctional immune system either because of the tumor's presence in the body or as a side effect of drugs or radiation used to treat the tumor," explained Mul. "The designer lymph nodes, aimed at rebuilding their immune systems, may overcome this dysfunction."

According to Mul, the researchers are using antigen-presenting cells made from the patient's blood, which are then genetically manipulated to express certain genes before injection into patients. They can inject gene-modified cells at multiple, independent sites throughout the body to create independent lymph nodes that work together.

In the trial, the researchers have found early formation of lymph nodes at the vaccine injection sites and are subsequently testing the nature and anti-tumor function of them.

Mul and colleagues anticipate partnering with other Florida-based institutions to create designer lymph nodes for diseases other than cancer and expand their designer gene immunity boosting research into fighting infectious diseases and even improving the function of immune systems in the elderly.


'/>"/>

Contact: Patty Kim
patty.kim@moffitt.org
813-745-7322
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Related medicine news :

1. Moffitt researchers find adolescents with cancer concerned about their future reproductive health
2. Moffitt Cancer Center researchers working at frontiers of melanoma research
3. Moffitt Cancer Center researchers: Quality of life as important as quantity of life
4. UCLA researchers combat global disease with a cell phone, Google Maps and a lot of ingenuity
5. Spinal cord injury researchers win Apple Award for article on niacin for dyslipidemia
6. Moffitt researchers find cancer therapies affect cognitive functioning among breast cancer survivors
7. Gene Behind Psoriasis Identified, Researchers Say
8. McMaster researchers find potential for new uses of old drug
9. Football helmet sensors help researchers demystify concussion in young athletes
10. Researchers Repair Damage Caused by Heart Attacks in Mice
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2019)... , ... December 04, 2019 , ... ... Opuntia Mesocarp Extract®, provides protection from disruptions to cells and tissue and inflammation ... menace of Jet Lag, is available in a dietary supplement product called ...
(Date:12/4/2019)... NEW YORK (PRWEB) , ... December 04, 2019 ... ... a Phase I study of AZD4041 for treating tobacco use and dependence. The ... is a central nervous system (CNS) penetrant antagonist of orexin-1 (hypocretin-1) receptors that ...
(Date:11/30/2019)... Texas (PRWEB) , ... November 28, 2019 , ... As ... may be the last such holiday for one of their loved ones. For those ... them to be home for the holiday season. , Spending their final months at ...
(Date:11/27/2019)... DIEGO (PRWEB) , ... November 27, 2019 , ... ... today announced that its cloud-based platform Nucleus.io has debuted major feature sets that ... This release will be shared with the public for the first time at ...
(Date:11/24/2019)... ... November 23, 2019 , ... At the 7th annual JADPRO ... presented the second annual Mary Pazdur Award for Excellence in Advanced Practice in ... Arizona. , Dr. Pelusi, a nurse practitioner, educator, and clinical trial sub-investigator with ...
Breaking Medicine News(10 mins):
(Date:11/23/2019)... ... November 22, 2019 , ... For the third year in a ... annual USGBC Greenbuild conference and expo in addition to showcasing a test installation of ... company’s Patcraft, Shaw Contract and Shaw Floors Builder Group brands. , Shaw offered five ...
(Date:11/23/2019)... (PRWEB) , ... November 23, 2019 , ... ... -- the number of birthdays we’ve celebrated -- has also broadly served as ... age isn’t the best way to make those assessments? , Researchers at the ...
(Date:11/22/2019)... ... November 22, 2019 , ... ... at Misch International Implant Institute. Completing this three-year program enhances Dr. Hogan’s expertise ... who are seeking permanent tooth replacement solutions. The Misch International Implant Institute has ...
Breaking Medicine Technology: