Navigation Links
Researchers create first molecule blocks key component of cancer genes' on-off switch
Date:9/24/2010

ich instructions to begin or cease activity are inscribed.

The instructions themselves take the form of "bookmarks," substances placed on the chromatin by so-called epigenetic "writer" proteins. Another group of epigenetic proteins, known as "erasers," are able to remove the bookmarks. Both types of proteins have successfully been disabled by scientists, using molecules made in the lab or taken from nature. Their success has sparked intense interest in the development of anti-cancer therapies that work by blocking such proteins.

A third variety of epigenetic proteins potentially the most appealing as therapeutic targets, because they switch genes on or off by "reading" the bookmarks has received scant scientific attention. Bradner and his colleagues turned to this little-explored corner of biology by focusing on NMC cells.

The disease is caused by a chromosomal "translocation," in which two genes from different chromosomes become connected and give rise to an abnormal, fused protein known as BRD4-NUT. A review of the scientific literature suggested that some members of the benzodiazepine family of drugs, which includes Valium, Xanax and Ativan, are active against "bromodomain" proteins such as BRD4. With that as a clue, Bradner and his Dana-Farber colleague Jun Qi, PhD, created an array of molecules to see if any inhibited a "reader" protein of the BRD4-NUT gene. One did, quite convincingly a hybrid molecule, which researchers named JQ1, for Qi.

The investigators worked with researchers in the U.S. and overseas to learn more about the properties of JQ1 and how it works in cells. Stefan Knapp, PhD, of Oxford University in England, provided crystal-clear images of the molecule bound to a protein; Olaf Wiest, PhD, of the University of Notre Dame, showed that the molecule is less flexible in the presence of a protein, explaining why it so effectively blocks the protein; and Andrew Kung, MD, PhD, of Dana-Farber, engineer
'/>"/>

Contact: Teresa Herbert
teresa_herbert@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers create first molecule-blocks key component of cancer genes on-off switch
2. Team of researchers finds possible new genetic risk for Alzheimers disease
3. UCLA cancer researchers discover new signaling pathway that controls cell development and cancer
4. European Researchers Find Genes Tied to Asthma
5. New treatment for severe aortic stenosis shown to save lives, Stanford researchers say
6. Queens University researchers locate impulse control center in brain
7. Researchers investigate differences in quality of care delivered by US resident and staff physicians
8. UNC researchers identify genetic patterns that may predict osteoarthritis
9. Mayo-led researchers discover genetic variants modifying breast cancer risk
10. Rutgers researchers discover how HIV resists AZT
11. Researchers at SUNY Downstate find drug combination may treat traumatic brain injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... (PRWEB) September 19, 2014 AttorneyOne.com, a recognized ... latest information from the FDA on Potassium Chloride . ... International Inc. recalled one lot of Potassium Chloride ... the shipping cartons. Potassium Chloride, administered intravenously, is used to ... is based on a labeling error on the shipping cartons ...
(Date:9/19/2014)... Texas (PRWEB) September 19, 2014 Yisrayl Hawkins, ... this week expounding on the need to protect children. He ... place with Michael Brown and reminds that there are many ... victimized. Yisrayl says violence is spreading faster than cancer all ... training. , “There are close to seven billion Michaels in ...
(Date:9/19/2014)... VogueQueen.com has recently unveiled a new line ... beautiful at their weddings. The new range has hundreds ... new products are made for the coming autumn. Moreover, ... the global clients. , “The bridal gowns ... several items on its website. I'm very satisfied with ...
(Date:9/18/2014)... York, New York (PRWEB) September 18, 2014 ... Xarelto lawsuits ( http://www.xareltolawsuitcenter.com ) currently pending in ... to have all claims filed on behalf of ... to motions filed on September 11th, the defendants ... other claims contained in the lawsuits have no ...
(Date:9/18/2014)... 18, 2014 Dr. David A. F. ... the American Academy of Facial Plastic and Reconstructive Surgery ... the Division of Facial Plastic Surgery. He is ... plastic surgery. , Dr. Ellis will be presenting ... be presenting on injection techniques and various treatments for ...
Breaking Medicine News(10 mins):Health News:Baxter Recalls Potassium Chloride Injection: AttorneyOne Monitors and Keeps Consumers Informed 2Health News:Yisrayl Hawkins Says the Michael Brown Scenario Will Continue Without Swift Action in New Post 2Health News:VogueQueen.com’s New Line Of Cheap Wedding Dresses Aims To Attract Chic Ladies 2Health News:Xarelto Lawsuit Defendants Seek to Have Pennsylvania Claims Filed by Out-of-State Plaintiffs Dismissed, Bernstein Liebhard LLP Reports 2Health News:Xarelto Lawsuit Defendants Seek to Have Pennsylvania Claims Filed by Out-of-State Plaintiffs Dismissed, Bernstein Liebhard LLP Reports 3Health News:Dr. David A. F. Ellis Has Been Invited to Speak at a Conference of the American Academy of Facial Plastic and Reconstructive Surgery in Orlando, Florida 2
... that pelvic imaging using computed tomography (CT) examinations are ... and eliminating this exam can significantly reduce a patient,s ... the pelvis during CT pulmonary angiography does not improve ... author for this study. He asserts, "Using CT venography ...
... FOR DETERMINING SOURCE OF ACUTE SHORTNESS OF BREATH ... replace standard chest x-ray as the first choice of ... source of acute dyspnea is needed. Italian researchers studied ... strong agreement between the results of chest ultrasonography and ...
... Inhaled Beta-agonists Increase Survival Over Anticholinergics ... agents are commonly prescribed to manage chronic obstructive ... to decrease exacerbations and hospitalizations and improve COPD ... mortality. However, it is not known which therapy ...
... HealthDay Reporter , MONDAY, May 2 (HealthDay News) -- The ... than the brains of normally developing children, and the difference ... The finding is a follow-up to earlier research that found ... of similarly aged normally developing kids, researchers said. ...
... Reporter , MONDAY, May 2 (HealthDay News) -- Kids who ... up getting injured more often, new research suggests. ... pursuit were almost twice as likely to get hurt as ... Neeru Jayanthi, medical director of primary care sports medicine at ...
... May 2 (HealthDay News) -- American workers forced to travel ... study suggests. A team of U.S. researchers found that ... are at higher risk for cardiovascular disease than "light" travelers who ... The team at Columbia University,s Mailman School of Public Health analyzed ...
Cached Medicine News:Health News:Chest journal news briefs, May 2011 issue 2Health News:Embargoed news from Annals of Internal Medicine 2Health News:Embargoed news from Annals of Internal Medicine 3Health News:Brains of Autistic Kids Still Larger at Age 4, 5 2Health News:Brains of Autistic Kids Still Larger at Age 4, 5 3Health News:Kids Specializing in One Sport More Likely to Get Hurt: Study 2Health News:Kids Specializing in One Sport More Likely to Get Hurt: Study 3Health News:Frequent Business Travel Tough on the Heart, Study Finds 2
(Date:9/18/2014)... Sept. 18, 2014   MacPractice,s MacPractice MD ... Complete EHR certification, which designates that the software is ... 1 and Stage 2 Meaningful Use measures required to ... Act (ARRA).  MacPractice MD MU version 5.0 was certified ... an Office of the National Coordinator-Authorized Certification Body (ONC-ACB) ...
(Date:9/18/2014)... --This BCC Research report discusses the medical device technologies in ... size, and opportunities for different devices and regions. It includes ... in the report focuses on technological trends in recent years ... and Japan . ... medical device technologies market. - Analyze market structure, including segments ...
(Date:9/18/2014)... , Sept. 18, 2014  KIYATEC announced ... million Small Business Innovation Research (SBIR) Phase II ... of the 27 institutes and centers that comprise ... course of the two year award, KIYATEC will ... two issues at the forefront of cancer therapy ...
Breaking Medicine Technology:MacPractice MD MU Achieves ONC HIT 2014 Edition Complete EHR Certification from ICSA Labs 2MacPractice MD MU Achieves ONC HIT 2014 Edition Complete EHR Certification from ICSA Labs 3MacPractice MD MU Achieves ONC HIT 2014 Edition Complete EHR Certification from ICSA Labs 4MacPractice MD MU Achieves ONC HIT 2014 Edition Complete EHR Certification from ICSA Labs 5Medical Devices: Technologies and Global Markets 2Medical Devices: Technologies and Global Markets 3Medical Devices: Technologies and Global Markets 4National Cancer Institute Awards KIYATEC Nearly $2M to Advance Predictive Cancer Diagnostics 2National Cancer Institute Awards KIYATEC Nearly $2M to Advance Predictive Cancer Diagnostics 3
... March 2007 - Cancer drug,developer Antisoma plc (LSE: ... from its second, confirmatory phase II,trial of AS1404 ... trial tested an 1800 mg/m2 dose of AS1404 ... response rate of 50%. A further 43% of,patients ...
... BioSciences,Inc., a specialty dermatology company, today announced the,publication of ... the journal,Cell by its co-founder and board member, David ... an important protein,p53, in the pigmentation of skin. Fisher's ... tumor suppressor in other cancers in,the body, p53 also ...
Cached Medicine Technology:Antisoma plc (UK) - Second lung cancer trial adds to positive data,on AS1404 2Antisoma plc (UK) - Second lung cancer trial adds to positive data,on AS1404 3Study in Cell by Magen BioSciences Co-Founder David E. Fisher,Identifies New Roles in Skin Cancer Prevention for Key Tumor,Suppressor Protein 2
... LASIK Marker Has Two ... Evenly Distributed Marks, Providing ... Lamellar Flap To Insure ... Marks Prevent Inadvertent Placement ...
... Be Used With The Gills Nomograms. 6mm ... Cornea For Making Limbal Relaxing Incisions., , 8-12108-5 ... Nomograms. 6mm & 8mm Chord Length Radials Placed ... Inner Circle Assists In Sizing A Precise Capsulorrhexis ...
... Manually Dilate A Small Pupil With Greater ... Safety By Allowing The Iris Hooks To ... The Plane Of The Anterior Capsule, Thus ... Pupil Stretching Is Also Maximized, With The ...
... Unique Reversible Speculums Designed To Rest ... Flipping The Speculums Over, Allowing Eyelids ... Fissures To The Widest Possible Aperture., ... Providing Unobstructed Around-The-Clock Access To The ...
Medicine Products: