Navigation Links
Researchers create first molecule blocks key component of cancer genes' on-off switch
Date:9/24/2010

BOSTONIn the quest to arrest the growth and spread of tumors, there have been many attempts to get cancer genes to ignore their internal instruction manual. In a new study, a team led by Dana-Farber Cancer Institute scientists has created the first molecule able to prevent cancer genes from "hearing" those instructions, stifling the cancer process at its root.

The study, published online by the journal Nature, demonstrates that proteins issuing stop and start commands to a cancer gene known as epigenetic "reader" proteins can be targeted for future cancer therapies. The research is particularly relevant to a rare but devastating cancer of children and young adults known as NUT midline carcinoma (NMC) a disease so obstinate that no potential therapy for it has ever reached the stage of being tested in a clinical trial.

"In recent years, it has become clear that being able to control gene activity in cancer manipulating which genes are 'on' or 'off' can be a high-impact approach to the disease," says the study's senior author, James Bradner, MD, of Dana-Farber. "If you can switch off a cancer cell's growth genes, the cell will die. Alternatively, switching on a tissue gene can cause a cancer cell to become a more normal tissue cell."

In this study, Bradner's lab synthesized a molecule that has both effects: by blocking a specific abnormal protein in NUT midline carcinoma cells, it stops them from dividing so prolifically and makes them 'forget' they're cancer cells and start appearing more like normal cells.

The assembled molecule affects the cell's multi-layered apparatus for controlling gene activity, a set of structures collectively known as the epigenome. Vast portions of each gene play a regulatory role, dictating whether the gene is active, busily sending orders for new proteins, or inactive, and temporarily at rest. The gene's DNA is packaged in a substance called chromatin, which is the slate on wh
'/>"/>

Contact: Teresa Herbert
teresa_herbert@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers create first molecule-blocks key component of cancer genes on-off switch
2. Team of researchers finds possible new genetic risk for Alzheimers disease
3. UCLA cancer researchers discover new signaling pathway that controls cell development and cancer
4. European Researchers Find Genes Tied to Asthma
5. New treatment for severe aortic stenosis shown to save lives, Stanford researchers say
6. Queens University researchers locate impulse control center in brain
7. Researchers investigate differences in quality of care delivered by US resident and staff physicians
8. UNC researchers identify genetic patterns that may predict osteoarthritis
9. Mayo-led researchers discover genetic variants modifying breast cancer risk
10. Rutgers researchers discover how HIV resists AZT
11. Researchers at SUNY Downstate find drug combination may treat traumatic brain injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Padre Murphy's and Owner Tom Boyle in Glendale, AZ has ... (PPHA). The PPHA's passion for others' well-being and shared ... treated for obstructive sleep apnea (OSA) has propelled them into ... the valley. The most recent plans for an event will ...
(Date:1/22/2015)... Houston, TX (PRWEB) January 22, 2015 The ... Pro Bodybuilder Ben Pakulski to increase lean muscle by up ... This has caught the attention of HealthyandFitZone.com’s Stan Stevenson, prompting ... shows that it is a step-by-step, scientific diet formula that ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Blue Cross and ... Minnesotans who exemplify what it means to “Live Fearless.” ... for people to share their stories about how they or ... simply inspired others by living in the moment. By telling ...
(Date:1/22/2015)... New York, New York (PRWEB) January 22, 2015 ... ( http://www.vaginalmeshlawsuit2015.com/ ) in the U.S. District Court, Southern District ... against C.R. Bard, Inc. in that proceeding’s first bellwether trial. ... defense request for a new trial after finding that C.R. ...
(Date:1/22/2015)... 22, 2015 A new white paper ... and person-centeredness in the long-term care environment as well ... the continuum. The paper, “The Power of Person-Centeredness in ... and practices of the patient, resident and family experience ...
Breaking Medicine News(10 mins):Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3
... Aeon Bioscience,Inc. today announced the recent acquisition ... Inc. by SurModics, Inc., a major,development in ... stent,technology for the treatment of cardiovascular disease., ... collaborative enterprise between,Brookwood Pharmaceuticals, Inc. and Targeted ...
... Gaps in ... and Mortality, AUSTIN, Texas, Oct. 10 Tonight, the ... hundreds of breast cancer survivors,and activists at the Komen Community ... singer Kelly Willis, Senator Kirk,Watson (D-Austin), Representative Patrick Rose (D-Dripping ...
... fine spatial details, such as the raised dots used ... blind. With that in mind, a team of researchers ... through touch. Understanding this circuitry may lead to the ... the visually impaired. , The findings appear in the ...
... This afternoon Governor,Arnold Schwarzenegger held a ... session with the state legislature aimed at ... spokesperson from the,Employment Policies Institute issued the ... employers will not solve California,s,health care crisis," ...
... Sustainable Improvements in Water Quality and Nutrient ... ... DD ),today announced a pledge of $250,000 to The Nature Conservancy in ... excess nutrient runoff from agricultural fields. DuPont is a charter member ...
... Promising results in mice need to be repeated in ... -- Researchers say they,ve made new strides in harnessing ... by multiple sclerosis. , According to the U.S. team, ... to laboratory mice repaired myelin, the protective sheath that ...
Cached Medicine News:Health News:Aeon Bioscience Continues Development of Drug Eluting Stents 2Health News:Aeon Bioscience Continues Development of Drug Eluting Stents 3Health News:Aeon Bioscience Continues Development of Drug Eluting Stents 4Health News:Texas Affiliates of Susan G. Komen for the Cure, Sen. Kirk Watson, Rep. Patrick Rose, Singer Kelly Willis, Breast Cancer Survivors and Activists Rally for Passage of Proposition 15 2Health News:Texas Affiliates of Susan G. Komen for the Cure, Sen. Kirk Watson, Rep. Patrick Rose, Singer Kelly Willis, Breast Cancer Survivors and Activists Rally for Passage of Proposition 15 3Health News:Scientists identify brain circuits used in sensation of touch 2Health News:Scientists identify brain circuits used in sensation of touch 3Health News:DuPont Pledges $250,000 to Nature Conservancy for Water Quality Initiative 2Health News:DuPont Pledges $250,000 to Nature Conservancy for Water Quality Initiative 3Health News:DuPont Pledges $250,000 to Nature Conservancy for Water Quality Initiative 4Health News:Antibody Helps Repair MS Nerve Damage 2
(Date:1/23/2015)... Jan. 23, 2015  Now available for sale, The Armor1 ... that prevents ankle sprains by cushioning the ankle from ... securely around the outside of any shoe type and ... while still offering protection against sprains. With customers in ...
(Date:1/23/2015)... , Jan. 23, 2015   Leatt Corporation  (OTCQB: ... protective equipment for all forms of sports, including extreme ... neck brace, announced today that the UISP Lega Motociclismo ... requires all riders to wear a neck brace during ...
(Date:1/23/2015)... and BOSTON , January 23, ... drug discovery and development company, is delighted to announce that ... been awarded to Miles Congreve (Vice President of ... and Malcolm Weir (Chief Executive Officer and co-founder) ...
Breaking Medicine Technology:The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 3Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 2Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 3Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 4
... The new online pharmacy was launched after the company ... there are not enough reliable and trustworthy places to shop ... experience the company has, launching a website that would offer ... matter of time and patience. The new drugstore is bound ...
... AdvaMed 2010 : The MedTech ... of free educational Executive Workshops focused on bringing products to ... risk and global harmonization. The workshops take place at the ... and include speakers from the U.S. Food and Drug Administration, ...
Cached Medicine Technology:New Online Pharmacy RxBuys.com is Launched by One of the Leading Pharmaceutical Companies, Rx Corp 2Medical Device Conference Opens October 18, 2010 With Free Executive Workshops; Full Conference Highlights Latest Industry Trends, Technology Innovations and Keynote Speeches by the U.S. FDA Commissioner, U.S. CMS Administrator, CBS Evening News Anc 2
Extremely fine straight....
Curved delicate 5 mm blades....
Micro dressing forceps....
... The Leica M520 OH3 is ... best optical performance available on ... and unique stand. The Leica ... has the greatest range of ...
Medicine Products: