Navigation Links
Researchers create drug to keep tumor growth switched off
Date:2/11/2010

A novel and rapid anti-cancer drug development strategy has resulted in a new drug that stops kidney and pancreatic tumors from growing in mice. Researchers at the Moores Cancer Center at the University of California, San Diego, have found a drug that binds to a molecular "switch" found in cancer cells and cancer-associated blood vessels to keep it in the "off" position.

"We locked the kinase switch in the off position in cancer and in tumor-associated blood vessels," which differs from the way current inhibitors attempt to block active kinases, said David Cheresh, PhD, professor and vice chair of pathology at the UCSD School of Medicine and the Moores UCSD Cancer Center, who led the work.

The new approach employs scaffold-based chemistry combined with supercomputer technology, allowing for rapid screening and development of drugs that are more selective for the tumor. The development and screening processes were used to identify potential drug candidates able to halt a growth signaling enzyme, or kinase, which can foster tumor blood vessel and tumor growth. According to the researchers, the novel approach may become a useful strategy in cancer drug development. The study appears online the week of February 8, 2010, in the Proceedings of the National Academy of Sciences.

In this "rational design approach," Cheresh and his co-workers used the supercomputer at the San Diego Supercomputer Center to custom-design molecules that stabilized the inactive forms of two similar kinases, PDGFRβ and B-RAF both of which are found to be activated in tumors and in blood vessels that feed tumors. Since PDGFRβ and B-RAF work cooperatively, keeping both turned off causes synergistic effects in tumors, according to Cheresh.

"We custom design a drug for a target that we know either plays a role in blood vessel angiogenesis or tumor invasion," said Cheresh. "By doing this on the computer screen and effectively locking the
'/>"/>

Contact: Steve Benowitz
sbenowitz@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
2. Researchers discover new way to kill pediatric brain tumors
3. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
4. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
5. UCSF Researchers Identify Regulator of Human Sperm Cells
6. Researchers find broad spectrum antiviral that fights multitude of viruses
7. Caregivers of ICU patients are collateral damage of critical illness, say Pitt researchers
8. Researchers fight world hunger by mapping the soybean genome
9. HIV researchers solve key puzzle after 20 years of trying
10. UC Davis researchers identify brain protein for synapse development
11. UCLA cancer researchers perform complete genomic sequencing of brain cancer cell line
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... 2014 The SI Joint Evaluation and ... six muscle energy techniques. Michael P. Reiman PT, DPT, ... examination techniques for the SI Joint. This ... live course presentation with North American Seminars. ... Applying a differential diagnosis approach to a thorough examination ...
(Date:8/30/2014)... The KSF (Kung Fu Sanshou Federation) presents ... November 8th, 2014 at the Mobile Civic Center in ... many notorious and notable fighters for some top international ... , Among these KSF along with the Shaolin ... with the virtues of true indomitable Shaolin spirit, among ...
(Date:8/30/2014)... Spain Saturday 30 August 2014: The first ... patients with acute coronary syndromes (ACS) are published ... position paper was written jointly by the European ... Association (ACCA) and the European Association of Percutaneous ... , Professor Bulent Gorenek (Turkey), chairperson of the ...
(Date:8/30/2014)... 2014: The first recommendations on the use of ... published today in new ESC Guidelines. The guidelines ... V. Konstantinides (Germany/Greece) and Professor Adam Torbicki (Poland). ... and management of acute pulmonary embolism" are published ... on the ESC Website. , Venous thromboembolism (VTE) ...
(Date:8/29/2014)... August 29, 2014 Daily Gossip writes in ... program on the market nowadays. This method promises to teach ... the use of some effective alternative sources for the production ... energy sources are wind and solar power. , The ... easily accessible in an eBook. So, this is an online ...
Breaking Medicine News(10 mins):Health News:North American Seminars Online PT Continuing Education Course, Examination and Treatment of the SI Joint, Receives Continuing Education Approval in NJ, CA, IL, PA, & TX 2Health News:KSF Presents US Open Challenge-K. Warrior Search, Seeking Inspirational Warrior Fighters Like Cung Le 2Health News:KSF Presents US Open Challenge-K. Warrior Search, Seeking Inspirational Warrior Fighters Like Cung Le 3Health News:KSF Presents US Open Challenge-K. Warrior Search, Seeking Inspirational Warrior Fighters Like Cung Le 4Health News:First multidisciplinary recommendations on management of arrhythmias in ACS patients 2Health News:First recommendations on all new oral anticoagulants in pulmonary embolism published 2Health News:Home Made Energy Review Exposes Simple Method to Access Alternative Energy Sources 2
... reneged on its pledge to provide more flexible working in ... Journal. , Nearly 70% of medical students are women, and ... But despite its pledges in 2000, made in the governments ... the policy commitment made by the pay negotiating body NHS ...
... on why some people suffer from recurrent episodes of ... by a drop in blood pressure, fainting episodes, difficulty ... these individuals, researchers have found mast cells (a type ... a mutated cell surface receptor that disturbs normal processes ...
... New research explains why some ovarian cancer patients ... post-operative treatment. The findings show that the difference between ... the different biological properties of the tumors. Understanding ovarian ... exploration of specific tumor-targeted therapy, such as DNA profiling, ...
... Protection Awareness, NORTH CHICAGO, Ill., Nov. 9 ... ABT ) has donated a "Cool Globes",sculpture from ... the Lake,County Forest Preserves (LCFP) as a permanent display ... The "Cool Globes" program, which Abbott sponsored, featured ...
... 9 NutraCea (OTC Bulletin Board:,NTRZ), a health ... rice bran,(SRB), announced today that it will release ... after the market closes. Management will host ... PM EST,to review NutraCea,s 2007 third quarter financial ...
... 9 The Menninger Clinic, the,international specialty psychiatric ... Mental Health Epicenter -- that include The,Clinic,s new ... research,treatment, training and advocacy., Menninger will be ... Center on South Main Street, near South Post ...
Cached Medicine News:Health News:UK government has reneged on pledge for flexible working in NHS 2Health News:Abnormal immune cells may cause unprovoked anaphylaxis 2Health News:Abnormal immune cells may cause unprovoked anaphylaxis 3Health News:Abbott Donates 'Cool Globe' to Lake County Forest Preserves for Permanent Display at Greenbelt Cultural Center 2Health News:Abbott Donates 'Cool Globe' to Lake County Forest Preserves for Permanent Display at Greenbelt Cultural Center 3Health News:NutraCea to Host Third Quarter 2007 Financial Results Conference Call November 14 2Health News:The Menninger Clinic Unveils Plans for Mental Health Epicenter; Exceeds Halfway Point in $125 Million Capital Campaign 2Health News:The Menninger Clinic Unveils Plans for Mental Health Epicenter; Exceeds Halfway Point in $125 Million Capital Campaign 3
(Date:8/29/2014)... SPRING, Md. , Aug. 29, 2014  United ... that the U.S. District Court for the District of ... its favor in the company,s case against Sandoz, Inc. ... Judge Peter Sheridan ruled that U.S. Patent ... Inc., and enjoined Sandoz from marketing its generic product ...
(Date:8/29/2014)... August 29, 2014 According ... Product & Services (Equipment, Reagent, Primer, Probe, Custom ... PCR, QPCR, Gene Synthesis, NGS, DNA, RNAi) - ... global Oligonucleotide Synthesis Market is expected to reach ... 2014, growing at a CAGR of 9.8% from ...
(Date:8/29/2014)... , Aug. 29, 2014  Unilife Corporation ("Unilife" or ... today that it intends to release its financial results ... June 30, 2014 after market trading ends on Tuesday, ... a conference call for 4:30 p.m. U.S. EDT on ... 6:30 a.m. AEST), to review the Company,s financial results, commercial ...
Breaking Medicine Technology:District Court Decision Received In Remodulin Patent Case 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 3Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 4Unilife Corporation to Announce Financial Results for Fiscal Year 2014 Fourth Quarter and Year End on Tuesday, September 9, 2014 2
... Sinovac Biotech Ltd. (Nasdaq: SVA ), a leading ... release its unaudited financial results for the first quarter ended ...  The Company will host a conference call on Tuesday, May ... 8:00 p.m. China Standard Time) to review the Company,s financial ...
... Perrigo Company (Nasdaq: PRGO ; TASE) today ... 2012. (Logo:   http://photos.prnewswire.com/prnh/20120301/DE62255LOGO ) ... "We are very pleased with our record fiscal third ... made possible by the continued operational excellence of the ...
Cached Medicine Technology:Sinovac to Host Conference Call to Report First Quarter 2012 Unaudited Financial Results 2Perrigo Reports Record Third Quarter Revenue And Earnings And Raises Full Year EPS Guidance 2Perrigo Reports Record Third Quarter Revenue And Earnings And Raises Full Year EPS Guidance 3Perrigo Reports Record Third Quarter Revenue And Earnings And Raises Full Year EPS Guidance 4Perrigo Reports Record Third Quarter Revenue And Earnings And Raises Full Year EPS Guidance 5Perrigo Reports Record Third Quarter Revenue And Earnings And Raises Full Year EPS Guidance 6Perrigo Reports Record Third Quarter Revenue And Earnings And Raises Full Year EPS Guidance 7Perrigo Reports Record Third Quarter Revenue And Earnings And Raises Full Year EPS Guidance 8Perrigo Reports Record Third Quarter Revenue And Earnings And Raises Full Year EPS Guidance 9Perrigo Reports Record Third Quarter Revenue And Earnings And Raises Full Year EPS Guidance 10Perrigo Reports Record Third Quarter Revenue And Earnings And Raises Full Year EPS Guidance 11Perrigo Reports Record Third Quarter Revenue And Earnings And Raises Full Year EPS Guidance 12Perrigo Reports Record Third Quarter Revenue And Earnings And Raises Full Year EPS Guidance 13Perrigo Reports Record Third Quarter Revenue And Earnings And Raises Full Year EPS Guidance 14Perrigo Reports Record Third Quarter Revenue And Earnings And Raises Full Year EPS Guidance 15Perrigo Reports Record Third Quarter Revenue And Earnings And Raises Full Year EPS Guidance 16Perrigo Reports Record Third Quarter Revenue And Earnings And Raises Full Year EPS Guidance 17Perrigo Reports Record Third Quarter Revenue And Earnings And Raises Full Year EPS Guidance 18
... a rapid, real-time thermal cycler used for ... automating much of the testing process, and ... is the fastest, easiest to use, and ... The SmartCycler delivers highly accurate and consistent ...
... is a rapid, real-time thermal cycler used ... By automating much of the testing process, ... it is the fastest, easiest to use, ... market. The SmartCycler delivers highly accurate and ...
... The SmartCycler System is a rapid, ... from prepared biological samples. By automating much ... reaction site individually programmable, it is the ... system now on the market. The SmartCycler ...
... is a rapid, real-time thermal cycler used ... By automating much of the testing process, ... it is the fastest, easiest to use, ... market. The SmartCycler delivers highly accurate and ...
Medicine Products: