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Researchers connect electrical brain disturbances to worse outcomes following neurotrauma
Date:5/19/2011

CINCINNATIElectrical disturbances that spread through an injured brain like tsunamis have a direct link to poor recovery and can last far longer than previously realized, researchers at the University of Cincinnati Neuroscience Institute (UCNI) have found.

The disturbances, known as cortical spreading depolarizations, are short-circuits (electrical failures) that occur in a localized, or specific, area of injury and result in dampened brain waves. Because of their localization, the depolarizations are invisible in routine electroencephalography (EEG) exams. But they represent an extreme change in voltageup to 10 times greater than any brain pattern that is normally present.

"Over the last several years we've learned how to measure and record spreading depolarization in the human brain, and we have known that these depolarizations occur in many patients who have suffered neurotrauma," says Jed Hartings, PhD, research assistant professor in UC's department of neurosurgery and director of clinical monitoring for the Mayfield Clinic. "But we didn't know what they meant or whether they were relevant. For the first time we now know that they relate to worse outcomes for patients who have suffered trauma to the brain."

That finding, Hartings adds, could eventually lead to new therapies. "If we can find a way to stabilize the brain's electrical activity and block spreading depolarizations, perhaps we can improve patients' outcomes."

An Advance Access, online version of the research, published April 7 by the neurology journal Brain (http://brain.oxfordjournals.org/) appears online in its complete, paginated form today.

The observational, multi-site study of 53 patients represents the initial phase of a four-year, $1.96 million grant awarded by the Department of Defense (DOD). The topic of spreading depolarizations is of keen interest to the U.S. military because head in
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Contact: Cindy Starr
cstarr@mayfieldclinic.com
513-558-3505
University of Cincinnati Academic Health Center
Source:Eurekalert

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