Navigation Links
Researchers conduct comprehensive review of treatments for depression in cancer patients
Date:6/26/2014

Depression is common in cancer, up to half of all patients facing the disease experience depressive symptoms, ranging from mild to severe. When depression co-exists with cancer, patients may be at an increased risk of death from cancer and from suicide.

Antidepressants are commonly prescribed, but the evidence on their efficacy is mixed. The role of antidepressants in treating cancer-related depression has not been rigorously studied. To identify best practice for the treatment of depression in cancer, Dartmouth researchers completed a systematic review and meta-analysis of existing research. The paper was published in General Hospital Psychiatry in June.

The review identified two classes of antidepressants that reduce symptoms of depression:

  • An alpha-2-adrenergic receptor antagonist: Mianserin
  • Two selective serotonin reuptake inhibitors: fluoxetine (Prozac) and paroxetine (Paxil)

Available evidence suggests that paroxetine and fluoxetine can improve depressive symptoms but may be less well-tolerated.

Miaserin also showed a higher depression response rate compared to placebo, whereas paroxetine and fluoxetine did not. The response rates were low suggesting only modest changes in depressive symptoms.

"All the evidence for alpha-2-andrenergic receptors was based on a single agent, Mianserin," said Natalie Riblet, MD, MPH, lead author of the study, Department of Psychiatry, Geisel School of Medicine. "Unfortunately, the most promising agent, Mianserin, is not available in the US. Given that Mirtazapine is a close pharmacological cousin of Mianserin, there may be clinical benefit to further exploring the role of Mirtazapine in the management of cancer-related depression."

In terms of side effect profiles, Mianserin appeared slightly more tolerable compared to placebo; paroxetine had slightly higher but nonsignificant dropout rate due to side effects compared to placebo; fluoxet
'/>"/>

Contact: Robin Dutcher
Robin.Dutcher@hitchcock.org
603-653-9056
The Geisel School of Medicine at Dartmouth
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Miriam Hospital researchers develop app focused on making obese adults less sedentary
2. Researchers home in on way to predict aggressiveness of oral cancer
3. Researchers call for patients who receive home nutritional care to have emergency plans
4. Chronic brain damage not as prevalent in NFL players, say researchers
5. Researchers treat incarceration as a disease epidemic, discover small changes help
6. Researchers publish one of the longest longitudinal studies of cognition in MS
7. SLU researchers see possible answer to chemo pain in a multiple sclerosis drug
8. Miriam Hospital researchers analyze AUDs, sexual behavior among South African men
9. Researchers find gene critical for development of brain motor center
10. New target: Researchers identify pancreatic cancer resistance mechanism
11. U of MD researchers receive NIH grant to study personalized medicine for genetic diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... illness-causing E. coli bacteria were found on nearly one-quarter ... new study. Researchers checked cilantro, basil and parsley ... Los Angeles and Orange counties in California, and in ... 24 percent were positive for E. coli. One sample ... Both types of bacteria can cause sometimes serious or ...
(Date:12/19/2014)... The cost of cancer treatment can cause financial stress ... Researchers examined data from 1,000 people in the United ... cancer. Of those patients, almost 900 had finished their ... advanced cancer. Nearly half of the patients said ... was linked with a poorer health-related quality of life. ...
(Date:12/19/2014)... Diet Doc strives to continue to provide ... weight loss by combining scientific fast weight loss ... company understand that remaining committed to a diet can ... and sugars from the diet can cause patients to ... loss goals. , For this reason, Diet Doc ...
(Date:12/19/2014)... December 19, 2014 B. E. Smith, ... healthcare providers, has been retained to lead a national ... Hospital in Franklin, Ind. The top executive search firm ... placed more than 900 healthcare executives into organizations. ... service hospital providing care to the residents of Johnson ...
(Date:12/19/2014)... Mobile Spa, has announced they now have a Virtual ... into a utopia for the Long Island community where the ... Tour showcases the beauty of the Spa On Wheels which ... The Virtual Tour shows viewers each of the rooms in ... Marla Kaplan-Pelle, Director states " It's hard to imagine that ...
Breaking Medicine News(10 mins):Health News:E. Coli Germs Found on Farmers Market Herbs 2Health News:Cancer Treatment Costs Weigh Heavily on Patients, Study Finds 2Health News:Diet Doc Incorporates Appetite Zap into their Already Impressive Collection of Diet Products to Jump Start the Metabolism and Burn Fat 4X Faster 2Health News:Diet Doc Incorporates Appetite Zap into their Already Impressive Collection of Diet Products to Jump Start the Metabolism and Burn Fat 4X Faster 3Health News:Diet Doc Incorporates Appetite Zap into their Already Impressive Collection of Diet Products to Jump Start the Metabolism and Burn Fat 4X Faster 4Health News:Johnson Memorial Hospital Retains B. E. Smith to Recruit New Chief Financial Officer 2Health News:Johnson Memorial Hospital Retains B. E. Smith to Recruit New Chief Financial Officer 3Health News:A Virtual Tour Of Hands On Mobile Massage Spa Is Now Available 2Health News:A Virtual Tour Of Hands On Mobile Massage Spa Is Now Available 3
... greatly increases the risk of heart diseases as an adult, according ... heart disease is not how much you weigh now, but how ... with a low birth weight are roughly twice as susceptible to ... an epidemologist at the University of Southampton, and a team at ...
... The right side of the brain helps people recognise ... from the Beth Israel Deaconess Medical Center in Boston ... ,The study joins a growing body of evidence ... in self-awareness.// Studies of self-awareness may provide unique insights ...
... who do not express their requests feel less satisfied with their ... not tell a patient everything on his mind. One may feel ... she may seem rushed, or it may be that the relationship ... as it could be.// ,Researchers at the University of ...
... differences in disease patterns in different mammals - and it ... genes with our primate cousins - yet they rarely get ... dogs do not suffer from high blood pressure, even when ... Professor of Comparative Medicine at the University of Houston and ...
... tool to the field of medicine. An interactive video ... treatment. The days when doctors told you what treatment ... participate in the decision-making process.// But sometimes this is ... new research comes up all the time. ...
... or sleep apnoea has the potential to alter voice characteristics. ... stops many times during the night - is to remodel ... is that the uvula - a flap of tissue at ... ,If the uvula is trimmed - in an operation called ...
Cached Medicine News:Health News:The right is responsible 2
(Date:12/19/2014)... , Dec. 18, 2014 Somewhere between dropping ... health was forgotten. But Audicus , a next-generation ... better this new year. Hearing loss is ... aging population, though it is often unaddressed. Forty-eight million ... has a hearing aid, mainly due to price. Hearing ...
(Date:12/19/2014)... 18, 2014  RESMED INC. (NYSE: RMD ) ... fiscal year 2015 results on Thursday, January 22, 2015, after ... with ResMed,s results will be issued after 1:00 p.m. US ... discuss operating results and future outlook. The earnings ... Time and the live webcast of the call can be ...
(Date:12/19/2014)... has witnessed robust development with the growth pace keeping at ... In 2012, the size of China ... worldwide soaring to 16.3%. It is projected that ... rate by around 20% in the upcoming years and that ... An integrated membrane industrial system has taken shape ...
Breaking Medicine Technology:Audicus Will Help People Resolve to Hear Better in 2015 2ResMed To Announce Second Quarter 2015 Results 2Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 2Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 3
Quantitative Plasma-based Factor XIII Incorporation Assay Kit...
Thrombin Activatable Fibrinolysis Inhibitor Assay Kit...
Pefakit in-TDT Calibrators and Controls...
PT-HS with Calcium - 2 ml...
Medicine Products: