Navigation Links
Researchers collaborate to find new vaccine technology decreases E. coli in beef cattle
Date:2/27/2008

MANHATTAN, KAN. -- Despite millions of dollars spent on food safety research over the last 10 years, ground beef recalls due to E. coli O157:H7 were higher in 2007 than in 2006, according to researchers from Kansas State University and West Texas A&M University. E. coli O157:H7 has been linked to foodborne illnesses in humans after consuming contaminated beef and produce.

"We have been studying the effects of a novel vaccine technology to make beef safer," said Dr. Dan Thomson, an associate professor at Kansas State University.

Thomson worked with Dr. Guy Loneragan, West Texas A&M University, and Dr. T.G. Nagaraja, of K-State, to examine the effects of this vaccine on its ability to decrease E. coli shedding in beef cattle.

"We had a decrease in cattle shedding E. coli by 54 percent in our first field study," Thomson said. "However, we increased the amount of SRP exposure in the second field study and decreased the rate of cattle shedding E. coli by 85 percent."

Loneragan said, "This tells us that efficacious interventions that predictably reduce the burden of E. coli O157 on cattle entering packing plants are needed. Successful interventions will reduce the burden of E. coli O157 to a level that is within the capacity of in-plant interventions to handle. If this can be achieved, then tremendous progress toward preventing E. coli O157 from ever getting into ground beef has been made. This vaccine appears to fit this purpose and has great promise."

The team's findings will be presented at the 2008 Beef Industry Safety Summit in Dallas March 5.

Thomson and his colleagues studied Siderophore receptor and porin -- SRP -- technology, which was developed by Epitopix, LLC in Willmar, Minn.

"Siderophore receptor and porin proteins are utilized by food borne pathogens like E. coli to acquire iron," Thomson said. "The SRP vaccine technology immunizes animals against these mechanisms and does not allow the bacteria to take up iron. Iron is to bacteria, as oxygen is to humans. Without iron consumption, the bacteria suffocate and can't grow or replicate."

"We conducted a challenge study, a natural infection study and two large pen field studies at commercial feedyards," Thomson said. "All studies showed positive results of this vaccine, making an impact on decreasing not only the number of the cattle shedding the bacteria but also decreasing the concentration of the bacteria being shed."

Super shedder cattle are cattle that shed E. coli in very high concentrations. "Our natural field study showed that the SRP technology vaccine reduces the number of super shedder cattle," Thomson said.

The two large pen feeding studies the team conducted utilized 20 pens and more than 1,200 head of cattle, Thomson said. The first study conducted in 2006 was funded in part by beef and veal producers and importers through their $1-per-head checkoff and was produced for the Cattlemen's Beef Board and state beef councils by the National Cattlemen's Beef Association. The second study was sponsored by Epitopix, LLC in 2007.


'/>"/>

Contact: Dan Thomson, DVM, Ph.D.
dthomson@vet.k-state.edu
785-532-4254
Kansas State University
Source:Eurekalert

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... Salt Lake City, UT (PRWEB) , ... February 05, 2016 , ... ... Activz Whole-Food Nutrition , announced that the much-anticipated feature with author Jahnavi Foster, ... Really Cool Humans Amateur TV Network. , Each week, on his weekly Whole-Food Warrior ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... addition of micro-needling services in their Napa Valley office. The technique utilizes the ... Surgery Associates, Dr. Canales and Dr. Furnas, are part of only a select ...
(Date:2/5/2016)... Miami, Florida (PRWEB) , ... February 05, 2016 ... ... largest non-profit organization devoted exclusively to funding innovative lymphoma research and serving the ... services – is poised to once again host, Swirl, A Wine Tasting Event ...
(Date:2/5/2016)... ... February 05, 2016 , ... Regular gym users know the ... to wait longer to access the treadmills. It’s a predictable trend. After the excesses ... weight and get in shape by joining gyms, starting new walking or running routines, ...
(Date:2/5/2016)... ... , ... At its annual meeting held last week, the American Parkinson Disease ... of Directors. Mr. McDermott succeeds former APDA Chairman, Fred Greene. , "We are pleased ... APDA President and CEO. “Pat has tirelessly served APDA since 2001 when he was ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... , Feb. 4, 2016  Edwards Lifesciences Corporation ... innovations for structural heart disease and critical care monitoring, ... share repurchase (ASR) agreement with Morgan Stanley & Co. ... This repurchase is part of the Company,s previously authorized ... Company,s common stock.  --> ...
(Date:2/4/2016)... , Feb. 4, 2016   Bernstein Liebhard LLP ... filed in the United States District Court for the District ... class (the "Class") consisting of all persons or entities who ... "Company") (NASDAQ: INSY ) from March 3, 2015 through ... and certain of its officers with violations of the Securities ...
(Date:2/4/2016)... N.J. , Feb. 4, 2016  Montoya Love ... Professional in the field of Pharmaceuticals. Montoya is the ... Manufacturing ... supplies, Becton Dickinson provides healthcare institutions, clinical ... equipment throughout fifty countries across the globe. ...
Breaking Medicine Technology: