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Researchers close in on new melanoma gene
Date:5/19/2008

at and prevent the disease.

The aim of our work is to identify and understand the genetic factors influencing melanoma so we can better predict risk estimates, said QIMRs Dr. Stuart MacGregor, co-first author on the study. This in turn, means people will be better informed and can take the right precautions to avoid developing this increasingly common cancer.

How The Study Works A genome-wide association study involves scanning the DNA from two sets of individuals: those with a particular disease (cases) and those of similar individuals without the disease (controls). The DNA of each sample then undergoes examination for strategically selected markers of genetic variation, called single nucleotide polymorphisms, or SNPs. If certain genetic variations are found to be significantly more frequent in people with the disease compared to people without disease, those variations are said to be "associated" with the disease. The associated genetic variations can serve as roadmaps to the region of the human genome where the disease-causing gene resides.

The study whose data collection began 20 years ago involved more than 4,000 Australian samples (2,019 cases and 2,105 controls) and was a joint project between Australian, American and European research groups.


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Contact: Galen Perry
gperry@tgen.org
602-343-8423
The Translational Genomics Research Institute
Source:Eurekalert

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