Navigation Links
Researchers characterize epigenetic fingerprint of 1,628 people
Date:6/1/2011

Until a decade, it was believed that differences between people were due solely to the existence of genetic changes, which are alterations in the sequence of our genes. The discoveries made during these last ten years show that beings with the same genetics like the twins and cloned animals may have different characteristics and disease due to epigenetic changes.

Epigenetics involves chemical signatures that are added to DNA and proteins that package it, to regulate their activity. The more recognized epigenetic brand is DNA methylation, a process based on the addition of a methyl chemical group into a part of our genetic puzzle. Therefore, while the genetic is like the alphabet, epigenetics is like the punctuation marks of a text.

The researcher Manel Esteller, director of the Epigenetics and Cancer Biology Program of the Bellvitge Biomedical Research Institute (IDIBELL), professor at the University of Barcelona and ICREA researcher, has coordinated a work that identifies the "epigenetic fingerprints" of 1,628 people, healthy volunteers and patients suffering from common diseases, such as cancer, and cardiovascular and neurodegenerative diseases. The findings are published this week in the scientific journal Genome Research.

'Photo finish'

"The study analyses thousands of sites of DNA methylation in this great set of physiological and pathological tissues, it would be like a photo finish in a race that teaches you the epigenome of the individual at a particular time" says Dr. Esteller.

The results from the research provide understanding of many processes of the human body and how these processes lead to disease. The IDIBELL researcher says that "in the case of cancer, the study shows that all human tumours suffer epigenetic inactivation of cancer-protective genes and also tumour cells lose their epigenetic memory and can not remember what healthy tissue was."

Dr. Esteller explains how these changes related to the cancerous disease are not instantaneous but gradually accumulate with aging of our bodies. The changes are different from those in dementia and other autoimmune diseases with different epigenomes.

A very interesting result for its potential applicability is that we could know the primary tumour of metastases with unknown origin: "If we know the tumour from which emerged these cells, we can provide the most appropriate therapy for a patient and improve his or her survival".

The investigation involves several IDIBELL researchers linked to IDIBELL's scientific partners: the Catalan Institute of Oncology, the University of Barcelona and the Bellvitge University Hospital.


'/>"/>

Contact: Jordi Morat
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, ... Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility ... home to some of the world’s leading providers of cereal and other breakfast foods. ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many ... been diagnosed with endometriosis. These women need a treatment plan to not only ... approach that can help for preservation of fertility and ultimately achieving a pregnancy. ...
(Date:6/25/2016)... Viejo, California (PRWEB) , ... June 25, 2016 , ... ... to fit their specific project," said Christina Austin - CEO of Pixel Film Studios. ... fully customizable and all within Final Cut Pro X . Simply select a ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health ... of their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards ... at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to ...
(Date:6/24/2016)... Michigan (PRWEB) , ... June 24, 2016 , ... June ... about the dangers associated with chronic pain and the benefits of holistic treatments, ... individuals who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has announced ... Forecast to 2022" report to their offering. ... the patients with kidney failure, it replaces the function of ... patient,s blood and thus the treatment helps to keep the ... balance. Increasing number of ESRD patients & ...
(Date:6/23/2016)... June 23, 2016 Roche (SIX: RO, ROG; ... for its Elecsys BRAHMS PCT (procalcitonin) assay as a ... septic shock. With this clearance, Roche is the first ... integrated solution for sepsis risk assessment and management. ... infection and PCT levels in blood can aid clinicians ...
(Date:6/23/2016)... Bracket , a leading clinical trial technology ... outcomes platform, Bracket eCOA (SM) 6.0, at the 52 ... 30, 2016 in Philadelphia , Pennsylvania.  A ... product of its kind to fully integrate with RTSM, will ... 6.0 is a flexible platform for electronic clinical outcomes assessments ...
Breaking Medicine Technology: