Navigation Links
Researchers challenge previous findings regarding widely used asthma treatment
Date:1/10/2008

WINSTON-SALEM, N.C. A new study published recently in The Lancet reveals that one of the most commonly used asthma medicines -- long-acting beta-agonists -- may not be associated with adverse events in people based on their genotype (gene variation), as previous studies had shown.

The study analyzed the effects of long-acting beta-agonist therapy, used in combination with inhaled corticosteroids, in asthmatics who have a specific beta-2 adrenergic receptor (ADRB2) genotype.

Investigators analyzed data from two clinical trials performed by AstraZeneca Pharmaceuticals LP. In each trial, patients were randomized to receive one of two different long-acting beta-agonists. In the case of each of the therapies, asthma symptoms and control improved, but no differences were observed based on the ADRB2 genotype.

These results are extremely important because previous studies on short-acting beta-agonists showed evidence for an adverse genotypic effect, said Eugene R. Bleecker, M.D., Thomas H. Davis Professor of Medicine, co-director of Center for Human Genomics at Wake Forest Baptist, and lead-investigator for the study. Smaller studies on long-acting beta-agonists have produced conflicting results.

Current guidelines recommend the use of combination therapy, with long-acting beta-agonists and inhaled corticosteroids, to control moderate to severe persistent asthma.

With over 2,000 patients in this study receiving combination therapy, it was reassuring that no adverse safety effects could be attributed to an individuals genotype, said Bleecker.

Ten percent of the U.S. population suffers from asthma. Each year, approximately 4,000 people die with asthma as the underlying cause.


'/>"/>

Contact: Shannon Koontz
shkoontz@wfubmc.edu
336-716-2415
Wake Forest University Baptist Medical Center
Source:Eurekalert

Page: 1

Related medicine news :

1. UT Health Science Center researchers decoding saliva to detect breast cancer
2. Protein power: Researchers trigger insulin production in diabetic mice
3. Researchers use neuroimaging to study ESP
4. UGA researchers receive $9 million in grants to study barriers to effective addiction treatment
5. Researchers seek to make cavity-causing bacteria self-destruct
6. Human factors researchers test voting systems for seniors that can improve voting accuracy and speed
7. New research tools are too complex for easy answers, researchers say
8. In largest U.S. Hep C trial, researchers determine weight-based dosing is key to optimal treatment
9. U of M researchers discover fast-acting cyanide antidote
10. SLU researchers show how to stop muscle weakness caused by myasthenia gravis
11. Researchers solve first structure of a key to intact DNA inheritance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... Nancy Chiaravalloti, PhD, of Kessler Foundation was named the ... City, New Jersey. Dr. Chiaravalloti spoke on April 24, ... topic of "Treating Cognitive Deficits Following Neurological Illness and ... a part of the long legacy of the Mendel ... "The field of rehabilitation research is a rewarding one. ...
(Date:4/24/2014)... at UT Southwestern Medical Center previously discovered that the ... adult heart lacks this ability. New research by the ... its incredible regenerative capability in adulthood, and the answer ... It is well-known that a major function of the ... But at the same time, oxygen is a highly ...
(Date:4/24/2014)... for BrainHealth will bring together national experts to ... at its inaugural Brain Health Summit, titled "The ... will include Dr. Sandra Bond Chapman, founder and ... Senator Chuck Grassley (R-IA), U.S. Representative Chaka Fattah ... Policy and Early Learning, U.S. Department of Education. ...
(Date:4/24/2014)... one out of three survivors of critical illness, ... The Lancet Respiratory Medicine , and the majority ... mentally. , It is one of the largest ... outcomes of critical care survivors, according to lead ... and it highlights a significant public health issue, ...
(Date:4/24/2014)... National Science Foundation has awarded LSU Health Sciences ... (REU) Site grant in the amount of $295,635. ... from diverse social and educational backgrounds, underrepresented in ... The project will provide students with training ... It will be led by Principal Investigator ...
Breaking Medicine News(10 mins):Health News:Kessler Foundation scientist named 63rd Mendel Lecturer by St. Peter's University 2Health News:Oxygen diminishes the heart's ability to regenerate, researchers discover 2Health News:Inaugural Brain Health Summit focuses on brain resilience and regeneration 2Health News:Vanderbilt study finds physical signs of depression common among ICU survivors 2Health News:Vanderbilt study finds physical signs of depression common among ICU survivors 3
... 20 proteins in the Wnt family are some of ... develops and grows, but for 30 years scientists have ... The proteins have eluded standard visualization techniques, in large ... water-based liquids normally used for biochemical studies. But once ...
... Institutes of Health (NIH) has awarded researchers at Albert ... $5.9 million grant to develop a new vaccine against tuberculosis ... multi drug-resistant and extensively drug-resistant. The grant will build on ... is based on genetically altered Mycobacterium smegmatis , which ...
... way to talk to someone about prognosis and quality of ... one had studied that question through direct observation, until the ... , The data is published online in the Journal ... E. Gramling, M.D., Sc.D., associate professor of Family Medicine at ...
... HealthDay Reporter , WEDNESDAY, May 30 (HealthDay News) -- How old ... humans possess the ability to judge whether a person has reached ... in the study correctly gauged whether the former wearer of an ... for the record, most didn,t think "old-people smell" was off-putting at ...
... Storrs HealthDay Reporter , WEDNESDAY, May 30 (HealthDay ... well as babies drinking cow,s milk formula on tests of ... study finds. But breast-fed babies score slightly higher than infants ... 20 percent of formula-fed babies in the United States are ...
... FORT KNOX, Ky., May 30, 2012 Last month, ... around the country attended the American College of Physicians, ... national medical student abstract competitions and share their perspective ... residents earned national awards for their research. "The ...
Cached Medicine News:Health News:New molecular structure offers first picture of a protein family vital to human health 2Health News:New molecular structure offers first picture of a protein family vital to human health 3Health News:Einstein awarded $6 million grant to develop new TB vaccine against drug-resistant strains 2Health News:Einstein awarded $6 million grant to develop new TB vaccine against drug-resistant strains 3Health News:Listening in, researchers learn about end-of-life communication 2Health News:Listening in, researchers learn about end-of-life communication 3Health News:Humans Can Sniff Out Old Age in Others, Study Shows 2Health News:Humans Can Sniff Out Old Age in Others, Study Shows 3Health News:Infant 'Smarts' Similar With Different Types of Formula: Study 2Health News:Infant 'Smarts' Similar With Different Types of Formula: Study 3Health News:Infant 'Smarts' Similar With Different Types of Formula: Study 4Health News:US Army internal medicine residents receive awards from American College of Physicians 2
(Date:1/15/2014)...  Manufacturers, suppliers and distributors of innovative medical-related products ... most important business assets, intellectual property (IP). ... Because of the highly-competitive nature of the Medical ... most litigious industry sectors of cases involving IP ...
(Date:1/15/2014)... 2014 Tegra Medical is very pleased to announce the ... new Chief Executive Officer.  Mark was promoted from his current ... the company,s four facilities in Massachusetts , ... joined Tegra Medical in 2012 with 20+ years of broad-based ...
(Date:1/15/2014)... PHILADELPHIA , Jan. 15, 2014  Echo Therapeutics, Inc. ... company developing its Symphony® CGM System as a non-invasive, ... Robert F. Doman , Executive Chairman and Interim CEO ... Capital Markets, Tenth Annual Equity Conference. ...
Breaking Medicine Technology:Intellectual Property Insurance for Medical-related Products and Services 2Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3
Headlight module is mounted on UltraLite Plus sweatband....
... rapid rise in intracranial ... intervention and continuous monitoring. ... technology that gets to ... Its versatility makes it ...
... The CODMAN ICP Monitoring ... measurements of intracranial pressure ... or intraventricular levels. The ... rather than through a ...
... The Polaris system delivers the ... cost effective and easy to use, ... level of precision measurement with unprecedented ... both active and passive tools, the ...
Medicine Products: