Navigation Links
Researchers challenge previous findings regarding widely used asthma treatment
Date:1/10/2008

WINSTON-SALEM, N.C. A new study published recently in The Lancet reveals that one of the most commonly used asthma medicines -- long-acting beta-agonists -- may not be associated with adverse events in people based on their genotype (gene variation), as previous studies had shown.

The study analyzed the effects of long-acting beta-agonist therapy, used in combination with inhaled corticosteroids, in asthmatics who have a specific beta-2 adrenergic receptor (ADRB2) genotype.

Investigators analyzed data from two clinical trials performed by AstraZeneca Pharmaceuticals LP. In each trial, patients were randomized to receive one of two different long-acting beta-agonists. In the case of each of the therapies, asthma symptoms and control improved, but no differences were observed based on the ADRB2 genotype.

These results are extremely important because previous studies on short-acting beta-agonists showed evidence for an adverse genotypic effect, said Eugene R. Bleecker, M.D., Thomas H. Davis Professor of Medicine, co-director of Center for Human Genomics at Wake Forest Baptist, and lead-investigator for the study. Smaller studies on long-acting beta-agonists have produced conflicting results.

Current guidelines recommend the use of combination therapy, with long-acting beta-agonists and inhaled corticosteroids, to control moderate to severe persistent asthma.

With over 2,000 patients in this study receiving combination therapy, it was reassuring that no adverse safety effects could be attributed to an individuals genotype, said Bleecker.

Ten percent of the U.S. population suffers from asthma. Each year, approximately 4,000 people die with asthma as the underlying cause.


'/>"/>

Contact: Shannon Koontz
shkoontz@wfubmc.edu
336-716-2415
Wake Forest University Baptist Medical Center
Source:Eurekalert

Page: 1

Related medicine news :

1. UT Health Science Center researchers decoding saliva to detect breast cancer
2. Protein power: Researchers trigger insulin production in diabetic mice
3. Researchers use neuroimaging to study ESP
4. UGA researchers receive $9 million in grants to study barriers to effective addiction treatment
5. Researchers seek to make cavity-causing bacteria self-destruct
6. Human factors researchers test voting systems for seniors that can improve voting accuracy and speed
7. New research tools are too complex for easy answers, researchers say
8. In largest U.S. Hep C trial, researchers determine weight-based dosing is key to optimal treatment
9. U of M researchers discover fast-acting cyanide antidote
10. SLU researchers show how to stop muscle weakness caused by myasthenia gravis
11. Researchers solve first structure of a key to intact DNA inheritance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... (PRWEB) November 26, 2014 Louisiana ... relief and specialists in minimally invasive spine surgery, ... Shamieh into the rapidly growing provider network of ... The addition coincides with the network’s continuing success ... treatment for Louisiana residents who are suffering from ...
(Date:11/26/2014)... of the most important and vital decisions a woman ... choosing the ideal wedding dress and bridesmaid dresses. BellasDress.com ... quality outfits. Today, BellasDress.com has unveiled its new range ... suitable bridesmaid gowns here at discount prices. , Formal ... and highlight all their most beautiful features while drawing ...
(Date:11/26/2014)... News) -- Teens prescribed anti-anxiety or sleep medications ... than other teens, a new study warns. ... abuse assessments on teenagers before prescribing these drugs ... parents don,t realize the abuse potential," said lead ... of Michigan School of Nursing. "These drugs produce ...
(Date:11/26/2014)... Steven Reinberg HealthDay Reporter ... rules announced Tuesday by the U.S. Food and Drug Administration ... menus, and the rules even apply to movie theater popcorn ... third of their calories away from home, often consuming less ... Dr. Margaret Hamburg said during a Monday afternoon news conference. ...
(Date:11/24/2014)... Recently, Fecbek.com ( http://www.fecbek.com ), a leading online shopping ... the history of the Black Friday to its fans worldwide. ... It is the Black Friday! It is a shopping day ... China. However, not everyone knows the history of the Special ... special day. , The fourth Friday in November is the ...
Breaking Medicine News(10 mins):Health News:Louisiana Back Institute Welcomes Dr. K. Samer Shamieh into Medical Provider Network 2Health News:Royal Blue Bridesmaid Dresses Now Are Available for Christmas at BellasDress.com 2Health News:Teens Given Anxiety, Sleep Meds May Be at Risk for Drug Abuse 2Health News:Calorie Counts Mandated at Chain Restaurants, FDA Says 2Health News:Calorie Counts Mandated at Chain Restaurants, FDA Says 3
... Balance Inc.,(Nasdaq: SMBL ) will hold its annual ... 21, 2008, at the Teaneck Marriott at Glenpointe, 100,Frank ... record,at the close of business on April 2, 2008, ... properly come before the meeting., About Smart Balance ...
... BATESVILLE, Ind., April 25 Hill-Rom Holdings,Inc.,s, (NYSE: ... be,issued Tuesday, May 13, 2008. You are invited to ... 2008 at 8:00 a.m. EDT., Earnings Release: Hill-Rom ... quarter ended March 31, 2008 will be released to,the ...
... Christina Predicts, uncanny gift for communicating with infants helps ... parents understand their little ones better, FLANDERS, ... uncertainty, many people would welcome the opportunity to learn,what the ... psychic reader,Christina Predicts., The recent highlighting of self-awareness by ...
... Proteasomes that control protein levels could key future treatments ... A new report finds that where protein-destroying machines reside ... memories are formed, a finding that may play a ... diseases. , Wake Forest University School of Medicine ...
... NutraCea (OTC Bulletin,Board: NTRZ), a world leader ... today announced that it has entered into,definitive agreements ... gross proceeds of $20,000,000. The offering is made,pursuant ... was filed by,NutraCea with the Securities and Exchange ...
... N.C., April 25 Managing multi-generational,diversity is emerging ... study with 23 leading companies, 80 percent deem ... yet only one-third say,their companies offer training in ... download an excerpt of,this new research, The High-Performing ...
Cached Medicine News:Health News:Hill-Rom Holdings, Inc. Invites You to Join Its Fiscal 2008 Second Quarter Earnings Webcast 2Health News:Internationally Known Psychic Christina Predicts Guides Others to Embrace a More Spiritual Way of Life 2Health News:When It Comes to Memory, It's All About Location 2Health News:NutraCea Announces $20 Million Securities Offering 2Health News:NutraCea Announces $20 Million Securities Offering 3Health News:Multi-generational Diversity Top Challenge for Businesses Today: Leading Company to Share Insights June 4-6 2
(Date:11/26/2014)... 2014 The medical magnetic resonance imaging ... 4%, with world market revenues for 2013 at ... other types of medical imaging have led to ... medical conditions in children and adults, each imaging ... Medical Imaging Markets , analyzes the current ...
(Date:11/26/2014)... , Nov. 25, 2014  At the American Dental ... this October, KaVo Kerr Group was honored to ... offering attendees the opportunity to see and test the ... opinion leaders deliver lectures on the latest developments in ... include the new DEXIS CariVu Caries Detection Device and ...
(Date:11/26/2014)... NEW YORK , Nov. 25, 2014 /PRNewswire/ ... with Covidien has been widely discussed in ... but it,s also creating a stronger leading player ... according to Kalorama Information.  The healthcare market research ... monitoring systems will feature a diverse set of ...
Breaking Medicine Technology:Kalorama: Steady Growth in the Medical MRI Market 2Kalorama: Steady Growth in the Medical MRI Market 3KaVo Kerr Group Showcased in Pride Institute Technology Expo at ADA Annual Meeting 2KaVo Kerr Group Showcased in Pride Institute Technology Expo at ADA Annual Meeting 3Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 2Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: