Navigation Links
Researchers challenge previous findings regarding widely used asthma treatment
Date:1/10/2008

WINSTON-SALEM, N.C. A new study published recently in The Lancet reveals that one of the most commonly used asthma medicines -- long-acting beta-agonists -- may not be associated with adverse events in people based on their genotype (gene variation), as previous studies had shown.

The study analyzed the effects of long-acting beta-agonist therapy, used in combination with inhaled corticosteroids, in asthmatics who have a specific beta-2 adrenergic receptor (ADRB2) genotype.

Investigators analyzed data from two clinical trials performed by AstraZeneca Pharmaceuticals LP. In each trial, patients were randomized to receive one of two different long-acting beta-agonists. In the case of each of the therapies, asthma symptoms and control improved, but no differences were observed based on the ADRB2 genotype.

These results are extremely important because previous studies on short-acting beta-agonists showed evidence for an adverse genotypic effect, said Eugene R. Bleecker, M.D., Thomas H. Davis Professor of Medicine, co-director of Center for Human Genomics at Wake Forest Baptist, and lead-investigator for the study. Smaller studies on long-acting beta-agonists have produced conflicting results.

Current guidelines recommend the use of combination therapy, with long-acting beta-agonists and inhaled corticosteroids, to control moderate to severe persistent asthma.

With over 2,000 patients in this study receiving combination therapy, it was reassuring that no adverse safety effects could be attributed to an individuals genotype, said Bleecker.

Ten percent of the U.S. population suffers from asthma. Each year, approximately 4,000 people die with asthma as the underlying cause.


'/>"/>

Contact: Shannon Koontz
shkoontz@wfubmc.edu
336-716-2415
Wake Forest University Baptist Medical Center
Source:Eurekalert

Page: 1

Related medicine news :

1. UT Health Science Center researchers decoding saliva to detect breast cancer
2. Protein power: Researchers trigger insulin production in diabetic mice
3. Researchers use neuroimaging to study ESP
4. UGA researchers receive $9 million in grants to study barriers to effective addiction treatment
5. Researchers seek to make cavity-causing bacteria self-destruct
6. Human factors researchers test voting systems for seniors that can improve voting accuracy and speed
7. New research tools are too complex for easy answers, researchers say
8. In largest U.S. Hep C trial, researchers determine weight-based dosing is key to optimal treatment
9. U of M researchers discover fast-acting cyanide antidote
10. SLU researchers show how to stop muscle weakness caused by myasthenia gravis
11. Researchers solve first structure of a key to intact DNA inheritance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... Calif., Sept. 30, 2014 Research by UC Irvine ... functions, shedding light on a vital process that determines ... In the online version of Nature Immunology , ... and other Institute for Immunology colleagues describe a critical ... released into the bloodstream. , A T cell is ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 EverStryke , ... free introduction to SurvivalLife.com along with a free book and ... attention of Shane Michaels, prompting an investigative review. , ... people in the survival and preparation niche, and this product ... the great classes and survival products that Joe offers on ...
(Date:9/30/2014)... Los Angeles, CA (PRWEB) September 30, 2014 ... plastic surgery providers in Turkey has gone up more ... of growth. The medical tourism company also reported total ... since October 2012. , The company’s professional strategy has ... in Turkey — ultimately designed for patient comfort and ...
(Date:9/30/2014)... 2014 Regenerative Medicine Solutions (RMS) is ... in Nashville, Tennessee. RMS welcomes the launch of an ... expansion of a new treatment center for the Lung ... Apnea Institute to Nashville, the hope is to bring ... both diagnosed and undiagnosed. With Nashville being a hub ...
(Date:9/30/2014)... Bifidobacteria, the primary bacteria found in the ... stress, so a high Bifido probiotic can help replenish ... Flora™ Men’s Complete contains 90 Billion live probiotic ... to support a healthy large intestine (colon) where elimination ... billion cultures from 7 Lactobacillus strains to help maintain ...
Breaking Medicine News(10 mins):Health News:UCI study uncovers important process for immune system development 2Health News:EverStryke: Review Exposes Joe Marshall’s Permanent Match Survival Product 2Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 2Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 3Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 4Health News:Regenerative Medicine Solutions Expanding 2Health News:ReNew Life Introduces Ultimate Flora™ Men’s Complete Probiotic 90 Billion—Comprehensive Probiotic Support Just for Men 2
... year,s Pennsylvania Farm Show can take advantage of free flu ... of Health,s "Body Shop" exhibit."Pennsylvania,s flu season got off to ... on the rise. Getting a flu shot now is the ... of illness," said acting Secretary of Health Everette James. Designed ...
... Keep Commitments the Whole Year ThroughWILSONVILLE, Ore., Jan. 8 ... . play video games? Just days ago, millions of Americans ... healthier and more productive lives. Whether it was a commitment ... ally can be found in the hottest video games of ...
... Japanese testing reveals longer protection from nausea and vomiting ... that better prevents the nausea and vomiting that commonly ... horizon, Japanese researchers report. , Studies headed by a ... palonosetron was not only as effective as the common ...
... America, Inc. launches its,next generation P-55C dye-sublimation thermal disc ... the CES Show at,the Las Vegas Convention Center, January ... printer can be integrated with 3 TEAC Autoprinter,configurations, TEAC ... and AL550S, customers can print up to 68 discs ...
... LAS VEGAS, Jan. 8 CardioVascular,BioTherapeutics, Inc. (OTC Bulletin ... United States opened for patient enrollment for,its ACORD Phase ... heart,disease. The sites are University of California ... Lauderdale, FL. , Mercy Hospital ...
... MDS Inc. (TSX: MDS; NYSE: MDZ ), a ... sciences markets, today reported its final fourth-quarter results following the ... 31, 2008. , As previously announced, for the fourth quarter ... value of the MDS Pharma Services goodwill write-down, previously estimated ...
Cached Medicine News:Health News:Video Games Make New Year's Resolutions Easier to Keep 2Health News:Video Games Make New Year's Resolutions Easier to Keep 3Health News:TEAC America Launches its Next Generation P-55C Printer, World's Fastest Dye-Sublimation Disc Printer 2Health News:CVBT Opens Two Additional Sites for Its ACORD Phase II Heart Trial 2Health News:MDS Reports Final Fourth-Quarter 2008 Results 2Health News:MDS Reports Final Fourth-Quarter 2008 Results 3Health News:MDS Reports Final Fourth-Quarter 2008 Results 4
(Date:9/30/2014)... Sept. 30, 2014 The signing of ... and New Jersey Health Foundation (NJHF) to work ... care programs has been announced by Rodger ... Kessler Foundation and James M. Golubieski , ... "The experience of New Jersey Health Foundation in ...
(Date:9/30/2014)... NEWPORT BEACH, Calif. , Sept. 30, 2014 ... prestigious accreditation of the American Association of Tissue ... Russell Cook , Chief Executive Officer. ... on-site inspection by a specially trained AATB inspector.  ... and administrative performance within the facility meets or ...
(Date:9/30/2014)... , Sept. 30, 2014 The Eastern European ... established medical-device providers as well as new medical-device manufacturers ... while simultaneously looking at ways to reduce the cost ... distributors is one of the effective means to achieve ... distribution market in Eastern European and provides profiles of ...
Breaking Medicine Technology:Kessler Foundation Partners with New Jersey Health Foundation To Start Innovative Companies To Change the Lives of People with Disabilities 2Biostructures, LLC Earns AATB Accreditation 2Medical Technologies Distributor Profiles in Eastern Europe 2Medical Technologies Distributor Profiles in Eastern Europe 3
... SAN DIEGO, Dec. 5, 2011 ForteBio®, Inc., a ... of biotherapeutic and pharmaceutical products, today announced the launch ... scientists – for the first time – to conduct ... and cost-efficiently at their lab bench. The new platform ...
... Bupa International has published two new health guides for ... information on vaccinations, medical insurance and emergency healthcare. ... a growing number of people relocate to foreign countries ... region is particularly needed, as the area,s many booming ...
Cached Medicine Technology:ForteBio Introduces BLItz™, a Revolutionary, Micro-volume Label-free Analysis Platform for Personal Assays 2ForteBio Introduces BLItz™, a Revolutionary, Micro-volume Label-free Analysis Platform for Personal Assays 3Bupa International Releases Health Guides to Hong Kong and Singapore 2
... first fully automated blood ... North American market based ... Test™. The ORTHO ProVue™ ... while increasing productivity via ...
The ScanGel® automatic readings are done with a high resolution color video camera. Images can be stored and printed....
... are in need of MRI exams, many ... scanners. They have heard of, or experienced ... and noisy tubes of supercon scanners - ... people want is a patient-friendly MRI. Now ...
... early 1990s, the "Reversed" shoulder prosthesis has ... great success. More recently, an ever-growing number ... begun to champion this prosthesis and the ... This reversed technology is the result of ...
Medicine Products: