Navigation Links
Researchers challenge previous findings regarding widely used asthma treatment
Date:1/10/2008

WINSTON-SALEM, N.C. A new study published recently in The Lancet reveals that one of the most commonly used asthma medicines -- long-acting beta-agonists -- may not be associated with adverse events in people based on their genotype (gene variation), as previous studies had shown.

The study analyzed the effects of long-acting beta-agonist therapy, used in combination with inhaled corticosteroids, in asthmatics who have a specific beta-2 adrenergic receptor (ADRB2) genotype.

Investigators analyzed data from two clinical trials performed by AstraZeneca Pharmaceuticals LP. In each trial, patients were randomized to receive one of two different long-acting beta-agonists. In the case of each of the therapies, asthma symptoms and control improved, but no differences were observed based on the ADRB2 genotype.

These results are extremely important because previous studies on short-acting beta-agonists showed evidence for an adverse genotypic effect, said Eugene R. Bleecker, M.D., Thomas H. Davis Professor of Medicine, co-director of Center for Human Genomics at Wake Forest Baptist, and lead-investigator for the study. Smaller studies on long-acting beta-agonists have produced conflicting results.

Current guidelines recommend the use of combination therapy, with long-acting beta-agonists and inhaled corticosteroids, to control moderate to severe persistent asthma.

With over 2,000 patients in this study receiving combination therapy, it was reassuring that no adverse safety effects could be attributed to an individuals genotype, said Bleecker.

Ten percent of the U.S. population suffers from asthma. Each year, approximately 4,000 people die with asthma as the underlying cause.


'/>"/>

Contact: Shannon Koontz
shkoontz@wfubmc.edu
336-716-2415
Wake Forest University Baptist Medical Center
Source:Eurekalert

Page: 1

Related medicine news :

1. UT Health Science Center researchers decoding saliva to detect breast cancer
2. Protein power: Researchers trigger insulin production in diabetic mice
3. Researchers use neuroimaging to study ESP
4. UGA researchers receive $9 million in grants to study barriers to effective addiction treatment
5. Researchers seek to make cavity-causing bacteria self-destruct
6. Human factors researchers test voting systems for seniors that can improve voting accuracy and speed
7. New research tools are too complex for easy answers, researchers say
8. In largest U.S. Hep C trial, researchers determine weight-based dosing is key to optimal treatment
9. U of M researchers discover fast-acting cyanide antidote
10. SLU researchers show how to stop muscle weakness caused by myasthenia gravis
11. Researchers solve first structure of a key to intact DNA inheritance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... ... February 09, 2016 , ... United ... In Praise of Prevention,” an animated video designed to prevent the ... translations of the video are being distributed throughout Togo, Liberia, Sierra Leone, Nigeria, ...
(Date:2/9/2016)... ... February 09, 2016 , ... The Brain Preservation Foundation’s (BPF) ... from 21st Century Medicine (21CM) ( http://www.21cm.com/ ), spearheaded by recent MIT ... of an intact rabbit brain for extremely long-term storage using a combination of ...
(Date:2/8/2016)... ... 08, 2016 , ... Coast Dental has a new way to help parents ... and family dentist Yvonne Dorrian, DMD, is hosting a free seminar on Friday, February ... to Target at 1207 North Peachtree Parkway in Peachtree City. Dr. Dorrian will have ...
(Date:2/8/2016)... ... February 08, 2016 , ... Brenton Engineering , ... bags, and flow wrapped products at WestPack 2015, February 9-11, in Anaheim, California. ... up to semi-automatic or fully-automatic case packing with a small footprint, rugged, highly ...
(Date:2/8/2016)... , ... February 08, 2016 , ... ... IN metro area, has selected the latest beneficiary of their ongoing community enrichment ... to preventing bullying in area schools. Donations are now being accepted at: ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... , February 9, 2016 ... gab heute den Abschluss eines Kooperationsvertrags mit ... umfassender Lösungen in den Bereichen Next-Generation-Sequencing (NGS), ... QGEN ; Frankfurt Prime Standard: QIA) gab ... Genomics für die Entwicklung und Förderung umfassender ...
(Date:2/9/2016)... WORCESTER, Mass. , Feb. 9, 2016   ... earned The Joint Commission,s Gold Seal of Approval ® ... continuous compliance with its performance standards. The Gold Seal ... that reflects an organization,s commitment to providing safe and ... --> AllCare Plus Pharmacy underwent a rigorous on-site ...
(Date:2/9/2016)... The leader in accelerated orthodontics, OrthoAccel ® ... the recipient of the 2015 Townie Choice Award in ... medical device that speeds up orthodontic tooth movement by ... associated with treatment, AcceleDent was selected by orthodontists from ... Orthotown survey of the most reliable and reputable ...
Breaking Medicine Technology: