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Researchers attack stem cells that cause colon cancer
Date:4/28/2010

Interestingly, Majumdar's laboratory has also had success disabling CSCs with curcumin, a principal constituent of turmeric, a spice commonly used in Indian cuisine. His studies have found that curcumin also can lower the number of IGF-1R and can reduce CSCs further when paired with the siRNA method he outlined in the current study.

The problem with combining the above mentioned anti-CSC strategies is that they can adversely affect normal adult stem cells which, if damaged, would only cause greater harm to the organism.

In addition, it is not yet clear whether reducing the number of CSCs can reduce the recurrence rate of colon cancer. However, Majumdar's laboratory has tried out the curcumin treatment with animals, with some encouraging results.

"Whether we can do this on humans without harming normal stem cells, that's the biggest challenge," Majumdar concluded.


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Contact: Donna Krupa
media@faseb.org
714-765-2012
Federation of American Societies for Experimental Biology
Source:Eurekalert

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