Navigation Links
Researchers at the UH Cancer Center discover protein that may control the spread of cancer
Date:2/26/2013

HONOLULU, HI - Researchers at the University of Hawai'i Cancer Center have uncovered a novel mechanism that may lead to more selective ways to stop cancer cells from spreading. Associate Professor Joe W. Ramos PhD, a cancer biologist at the UH Cancer Center and his team have identified the role of the protein RSK2 in cancer cell migration, part of the process of cancer metastasis.

Cancer becomes metastatic when cells break away from the primary tumor and spread to other parts of the body. Metastatic cancer is much more difficult to treat and patients with metastatic cancer have a generally worse prognosis. "The cancers that kill are those that spread to other parts of the body or disseminate within the organ," said Ramos. "If we could keep cancer cells confined to the primary tumor mass, we could remove it with less risk of metastasis and later recurrence."

The Ramos team reports that RSK2 significantly increases cell migration in part by reducing integrin activation. Integrins play an important role in cell adhesion to their surrounding tissue and the migration of tumor cells to new locations in the body. RSK is active in both breast and prostate tumors, and promotes proliferation in these cells. It can also promote cell invasion and metastasis in head and neck cancers in addition to lung cancer and neuroblastoma.

"We focused on understanding the process of cell adhesion," said Ramos. "Integrins help the cell move by grabbing onto proteins and cells in their surroundings, pulling, then releasing and grabbing on again. Blocking a cancer cell's ability to adhere and move can control further dissemination of some metastasis. There are drugs that kill cancer cells and there are drugs that stop the division of cancer cells, but there are far fewer drugs that specifically stop the movement of cancer cells. Our work suggests that drugs that interfere with RSKs may help control or prevent metastasis."


'/>"/>
Contact: Lori Strelow
lstrelow@cc.hawaii.edu
808-356-5753
University of Hawaii Cancer Center
Source:Eurekalert

Page: 1

Related medicine news :

1. Now hear this: Stanford researchers identify forerunners of inner-ear cells that enable hearing
2. Researchers explore PKC role in lung disease
3. Baylor University researchers study barriers, resources to physical activity in Texas towns
4. Researchers identify variations in 4 genes associated with an increased risk of colorectal cancer
5. Researchers identify variations in four genes associated with an increased risk of colorectal cancer
6. NIH-funded researchers begin trial of Shigella vaccine candidates
7. Moffitt researchers say silencing of retinoblastoma gene regulates differentiation of myeloid cells
8. Researchers guardians of trust in biobank research
9. Researchers Detect an Anti-Autism Advantage in Females
10. Einstein researchers present on imaging advances
11. Researchers at St. Michaels Hospital test tool for screening cancer patients for malnutrition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... ... February 11, 2016 , ... From March 4 through ... Dermatology Annual Meeting at the Walter E. Washington Convention Center in Washington, D.C. ... the condition of hyperhidrosis (excessive sweating) and its treatment options. Specifically, the company ...
(Date:2/11/2016)... Diego, CA (PRWEB) , ... February 11, 2016 , ... ... which was held in San Diego, CA, on February 6th & 7th, 2016 according ... combine for those who were not invited to the NFL’s combine in Indianapolis,” says ...
(Date:2/11/2016)... ... 11, 2016 , ... The book, “Computers Should Just Work!”, provides a basic, ... your IT consultant before signing a contract and how to spot an incompetent or ... relying heavily on e-mail and technology, it’s more important than ever to make sure ...
(Date:2/11/2016)... ... February 11, 2016 , ... As part of their 2015 end of ... Round Table Foundation (MDRTF), has gifted $10,000 to University of Chicago to support ovarian ... Billy Cundiff. , “We are honored to support a promising young investigator from Dr. ...
(Date:2/10/2016)... Culver City, California (PRWEB) , ... February 10, ... ... Molecular Imaging Society (WMIS), known as the World Molecular Imaging Congress (WMIC), will ... The theme for the 2016 meeting is “Imaging Biology…Improving Therapy.” The congress will ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... --> --> This press release is ... --> Japan .  --> A separate press release has ... Shire continues to strengthen its presence ... Shire continues to strengthen its presence in ... continues to strengthen its presence in ...
(Date:2/10/2016)... , Feb. 10, 2016  Resolve Therapeutics, ... transformative new approaches to the treatment of lupus ... of a multiple ascending dose study in patients ... compound RSLV-132. --> ... placebo-controlled multiple ascending dose study of RSLV-132 in ...
(Date:2/10/2016)... YORK , Feb. 10, 2016 Immune ... biopharmaceutical company, announced today that it has filed a ... Leukemia and other cancers. --> ... treating cancer by administration of Ceplene (histamine dihydrochloride) in ... provides methods of predicting the efficacy of Ceplene and ...
Breaking Medicine Technology: