Navigation Links
Researchers at the Gladstone Institutes find novel approach to reactivate latent HIV
Date:6/5/2014

SAN FRANCISCO, CAJune 5, 2014A team of scientists at the Gladstone Institutes has identified a new way to make latent HIV reveal itself, which could help overcome one of the biggest obstacles to finding a cure for HIV infection. They discovered that increasing the random activity, or noise, associated with HIV gene expressionwithout increasing the average level of gene expressioncan reactivate latent HIV. Their findings were published today in the journal Science.

When HIV infects an immune cell, it inserts its genetic material into the DNA of the infected cell. In most cases, the immune cell's machinery makes copies of the viral genetic material, a process known as transcription. This eventually leads to the productionor expressionof all the components needed to make more viruses. The new viruses are released from the infected cell and spread the infection to other immune cells in the body.

In some cases, however, HIV expression goes into a holding pattern and the virus enters a latent state within the infected immune cell. This means that a small percentage of HIV hides in infected cells, beyond the reach of even the most potent drugs. As a result, we cannot completely eliminate HIV from the body, and people with HIV infection have to take antiretroviral drugs (ARVs) for the rest of their lives.

"Understanding how to reactivate latent HIV is one of the major challenges we must overcome in order to find a cure for HIV," said Leor Weinberger, PhD, Associate Investigator in the Gladstone Institute of Virology and Immunology and senior author of the study. Roy Dar, PhD, the lead author of the study, added, "If we can make the virus show itself, we can then use ARVs to eliminate it. This so-called 'shock and kill' approach holds great promise, but to date it has unfortunately shown only limited success."

One of the properties of latency that makes it so difficult to address is that it is randomor stochasticin nature. Rand
'/>"/>

Contact: Ann Carollo
ann.carollo@gladstone.ucsf.edu
415-734-2008
Gladstone Institutes
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... Amsterdam, June 26, 2008 - Elsevier, the leading ... and services, today announced highlights of its Journal ... Journal Citation Reports published by ThomsonReuters, reports that ... respective categories. In addition, total Elsevier journal citations ...
... to Avastin at Improving Visual Acuity When, Used ... Share, ... Resources, WALTHAM, Mass., June 26 Decision Resources, ... on pharmaceutical and,healthcare issues, finds that Genentech/Novartis,s Lucentis will ...
... One of Canada,s Largest Academic Cancer Centers, ... ARAY ), a global leader in the field ... de Montreal (CHUM),has purchased a CyberKnife(R) Robotic Radiosurgery ... Montreal, Canada., CHUM, one of the largest ...
... Pharmaceuticals, Inc. (Nasdaq: AVRX), announced today the nomination of AVN316 ... Inhibitor program. This novel compound inhibits the Beta-catenin pathway and ... The Company plans to begin clinical testing of AVN316 in ... commonly activated cancer pathways and is known to play a ...
... who eat unhealthy, high-fat meals may experience memory declines ... antioxidant vitamins with the meal, according to new research ... diabetes to cognitive complications in humans. Adults with ... memory deficits after eating unhealthy foods. , This ...
... 2008 Tour Will Donate More than $1.6 Million and ... Dealers Supporting the Fight against Pediatric Cancer, FOUNTAIN ... on Wheels(TM) Tour launched yesterday in Los Angeles with ... Hospital Los,Angeles. The Tour will visit 32 children,s hospitals ...
Cached Medicine News:Health News:Elsevier announces 2007 journal impact factor highlights 2Health News:Because of Its Ability to Generate Higher Total Sales in the United States and Europe, Lucentis Will Earn Clinical Gold Standard Status by 2011 for the Treatment of Diabetic Retinopathy 2Health News:First CyberKnife System to be Installed in Canada 2Health News:First CyberKnife System to be Installed in Canada 3Health News:First CyberKnife System to be Installed in Canada 4Health News:Avalon Pharmaceuticals names lead development candidate in beta-catenin inhibitor program 2Health News:Seniors with type 2 diabetes may experience memory declines immediately after eating unhealthy meal 2Health News:Seniors with type 2 diabetes may experience memory declines immediately after eating unhealthy meal 3Health News:Hyundai Motor America and Its Dealers Launch National Hope on Wheels Tour to Support Pediatric Cancer Research 2Health News:Hyundai Motor America and Its Dealers Launch National Hope on Wheels Tour to Support Pediatric Cancer Research 3
(Date:12/17/2014)... 2014 , The ... hub of information concerning the biopharmaceutical Group,s national and international ... addition to the recently launched institutional website that is receiving ... enriched by a new chapter in the fascinating story of ... detailed and panoramic hub on the world of clinical research, ...
(Date:12/17/2014)... 2014 PCCA received the Autism Hope ... ) program seal for best practices in meeting ... medical practices, materials and goods that meet strict ... Children affected by autism often have unique physical ... ingredients found in food and medicine – for ...
(Date:12/15/2014)... Research and Markets , ... has announced the addition of the "Cardiac Guidewires ... their offering. Global Guidewires sector is projected to ... America accounts for nearly 35% (2015) of ... claims approximately 25% (2018). Asia-Pacific ...
Breaking Medicine Technology:Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 2Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 3Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 2Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 3Cardiac Guidewires - Global Trends, Estimates and Forecasts, 2012-2018 2Cardiac Guidewires - Global Trends, Estimates and Forecasts, 2012-2018 3Cardiac Guidewires - Global Trends, Estimates and Forecasts, 2012-2018 4
... a Range of Parameters. ... Enzyme, High Intensity, or ... Higher-Efficiency Transfers via Plate ... Transfers with Movable Electrodes. ...
... specifically designed to work with the EC120 ... a small tank blotter that incorporates the ... buffer requirements and fast transfer rates), with ... blotting such as arcing and buffer depletion. ...
... Trans-Blot SD semi-dry transfer cell ... blotting. Using a platinum-coated titanium ... a stainless steel plate as ... cell transfers in a horizontal ...
Semi-Dry Blotting Unit for 10 x 10cm Gels...
Medicine Products: