Navigation Links
Researchers at IRB Barcelona uncover new clues about the origin of cancer
Date:6/7/2012

A study by Travis H. Stracker, researcher at the Institute for Research in Biomedicine (IRB Barcelona), in collaboration with scientists at the Memorial Sloan Kettering Cancer Center (MSKCC) in New York, reveals new information about the origin of tumors. In this study, published in the journal Proceedings of the National Academy of Sciences (PNAS), the scientists postulate that the initiation of a tumor and the type and aggressivity of the same depend on a specific combination of defects in several processes that safeguard cell integrity, such as DNA repair pathways and cell cycle check-points. The study also demonstrates that mice with a high degree of chromosomal instability and defective programmed cell death (apoptosis), two hallmarks of cancer, rarely develop tumors.

"Whether or not a tumor develops depends on the moment of the cell cycle in which the damage occurs, which repair pathways components are affected, and which others are impaired in terms of apoptosis and cell cycle arrest", explains the North-American Travis H. Stracker, head of the "Genomic Instability and Cancer" group and an expert in DNA repair pathways and its implications on human health. In this study, H. Stracker and his team report on some of these combinations for the initiation of cancer and in different kinds of tissue. "The paper points out that our understanding of which aspects of damage response promote tumorigenesis and where they play a role in the process needs to be investigated further because it shows that it has been generalized and that there is a lot of specifics that are not at all clear."

The researchers utilized mice carrying mutations in key DNA repair genes involved in cancer. Next, they combined them with other mutations affecting cell cycle checkpoints or apoptosis until they hit upon the combinations that are sufficient to initiate tumorigenesis or to generate certain types of tumors. "It is like deconstructing cancer to find the factors responsible for it appearing", says H. Stracker.

During DNA replication in a dividing cell there is a series of checkpoints to test that duplication is taking place properly. If the cell detects errors in any of these phases, cell growth is halted and highly complex DNA repair processes are triggered. If the repair is defective and the cell accumulates many genomic errors, "watch-out" proteins step in, such as tumor suppressor p53. Such proteins activate programmed cell death (apoptosis) or cell cycle arrest (senescence). "A very complex network of pathways and proteins are involved", explains the researcher. "This study demonstrates that genomic instability per se is not sufficient to initiate a tumor and that we cannot generalize. We need to study the origin of different kinds of cancer in much greater depth and although it is as difficult as trying to find a needle in a haystack, we are slowly identifying the parts on which we should focus", he goes on to explain. The detection of the main players that cause different kinds of cancer could be of great interest for the design of new diagnostic tools and specific treatments.


'/>"/>
Contact: Snia Armengou
sonia.armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert  

Related medicine news :

1. HIV drug may slow down metastatic breast cancer, say researchers at Jeffersons Kimmel Cancer Center
2. Student researchers seek to develop new therapies for cancer
3. Researchers call for obesity prevention efforts to focus on community-wide systems
4. Listening in, researchers learn about end-of-life communication
5. 29 Johns Hopkins stem cell researchers awarded funding
6. Just do it! not good enough for cancer patients, UR researchers say
7. Researchers identify a life-and-death molecule on chronic leukemia cells
8. GW researchers discover biomarker for advanced bile duct fibrosis and bile duct cancer
9. Researchers restore neuron function to brains damaged by Huntingtons disease
10. UC San Diego researchers receive new CIRM funding
11. Ben-Gurion U. researchers successfully test solar desalination system for arid land agriculture
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers at IRB Barcelona uncover new clues about the origin of cancer
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution ... the emergency ambulance transport experience for the millions of people who require these ... disrupted the taxi industry through the use of technology. Now, SmartEMS has put ...
(Date:6/26/2016)... ... 2016 , ... PawPaws brand pet supplements owned by Whole Health ... the health of felines. The formula is all-natural and is made from Chinese herbs ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June ... , brings up a new, often overlooked aspect of head lice: the parasite’s ability to ... is not a common occurrence, but a necessary one in the event that lice have ...
(Date:6/25/2016)... , ... June 25, 2016 , ... On Friday, June ... a Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments ... of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...  Collagen Matrix, Inc., ("Collagen Matrix") the driving ... collagen and mineral based medical devices for tissue ... Messer has joined the company as Vice ... growing portfolio of oral surgery, neurosurgery, orthopaedic and ... the Collagen Matrix executive team as an accomplished ...
(Date:6/24/2016)... 2016 Dublin ... addition of the " Global Markets for Spectroscopy ... This report focuses on the ... review, including its applications in various applications. The report ... includes three main industries: pharmaceutical and biotechnology, food and ...
(Date:6/24/2016)... Dehaier Medical Systems Ltd. (NASDAQ: DHRM ) ... medical devices and wearable sleep respiratory products in ... with Hongyuan Supply Chain Management Co., Ltd. (hereinafter referred ... to develop Dehaier,s new Internet medical technology business. ... Hongyuan Supply Chain,s sales platform to reach Dehaier,s dealers ...
Breaking Medicine Technology: