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Researchers at Case Western Reserve discover a new way the body fights fungal infection
Date:6/11/2009

utic targets to help alleviate and/or eliminate Candida overgrowth and its accompanying symptoms, such as pain and discomfort, swelling, burning sensation of affected area, difficulty swallowing, in individuals suffering from infections.

The findings of Dr. Hise's laboratory will open many new avenues of research in fungal infections. One direction they are pursuing is to identify the way that the fungus activates the inflammasome. This might provide new targets for drug development. Another area of interest is the investigation of how small differences between individuals in immune related genes, called single nucleotide polymorphisms or SNPs, affect susceptibility to fungal and other infections.

"If we can identify patterns of SNPs that make people more likely to develop life-threatening fungal infections, it may be possible in the future to use these as markers to screen patients. For example, patients admitted to intensive care units or needing long-term invasive catheters could be genetically screened to identify who would benefit from preventive anti-fungal treatment," says Dr. Hise.


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Contact: Jessica Studeny
jessica.studeny@case.edu
216-368-4692
Case Western Reserve University
Source:Eurekalert

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