Navigation Links
Researchers advocate for more education and attention regarding rare breast cancer
Date:10/19/2010

PHILADELPHIA (October 19, 2010)Inflammatory breast cancer (IBC), an aggressive and rare malignancy, is often initially misdiagnosed as an infection or rash. However, getting the correct diagnosis quickly is critical for patients because the disease spreads beyond the breast in a matter of just days or weeks. With that in mind, leading specialists from The University of Texas MD Anderson Cancer Center and Fox Chase Cancer Center have written a review of the current scientific and medical understanding of IBC, which includes key information on diagnosis, imaging, treatment, and cutting-edge research.

"Inflammatory breast cancer is a disease that needs more attention, and more education for physicians and patients," says Massimo Cristofanilli, M.D., F.A.C.P., chair of the department of medical oncology at Fox Chase Cancer Center and senior author of the review, which will appear in the Nov/Dec issue of CA: A Cancer Journal for Clinicians.

The American Cancer Society estimates that IBC accounts for 2.5% of all breast cancer cases in the United States, with 192,370 new diagnoses and 40,170 deaths expected this year. Yet Cristofanilli emphasizes that it is not necessary for physicians to have already seen a case of IBC to diagnose it properly. "If you know about it and you have a clinical suspicion, it is important to reach out to a specialist as soon as possible," he says.

Patients frequently come to their primary physician or gynecologists complaining of reddened skin and swollen breast, which might be initially mistaken for a rash or infection. "Ninety-five percent of women with IBC receive antibiotics for a while before they are correctly diagnosed," Cristofanilli says. "But it is important to recognize that you cannot have an infection without fever. If a woman is not nursing, is 55 years old, and has no other risk factors for mastitis, it is much more likely that she has a cancer than an infection."

And though many oncologists have often considered IBC a type of locally advanced breast cancer, the reality is that IBC is a distinct disease. "A typical advanced breast cancer has a mass or nodule that grows over months or years, and eventually involves most of the breast and could show also with some redness," Cristofanilli says. "With IBC, you have a tumor that becomes clinically evident in just a few weeks sometimes women describe it as just a few days. The breast is red and inflamed, but there is no fever; within a few days, the cancer is already in the lymph nodes and there is no palpable mass. So if you picture these two situations, you clearly see there is no resemblance."

The difference in presentation and symptoms suggests that IBC has a distinct underlying biology, relative to locally-advanced breast cancer. And many years of research have shown that IBC does not respond to therapies used to treat other forms of breast cancer.

New and more effective therapies are in the works though, according to Cristofanilli and first author Fredika Robertson, Ph.D., professor in the Department of Experimental Therapeutics at The University of Texas MD Anderson Cancer Center. Basic science researchers, such as Robertson, are pinpointing molecular pathways that drive the formation and growth of IBC, and new agents targeted against those pathways are in development.

For example, on-going clinical trials are testing lapatinib, a tyrosine kinase inhibitor that blocks two signaling pathways that are frequently hyperactive in IBC. "Lapatinib is one of the few drugs that shows activity as a single drug in IBC, but this is still an evolution," Cristofanilli says. "The paper addresses some of the areas where we expect to see novel agents come and the direction we will go in the next few years."

"I think the future is bright if we are all able to come together and recognize that there is a need to put resources and research into this disease," he says. "And many researchers are already doing this."


'/>"/>

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Related medicine news :

1. Mount Sinai researchers discover why cocaine is so addictive
2. Temperature rhythms keep body clocks in sync, UT Southwestern researchers find
3. Need a study break to refresh? Maybe not, say Stanford researchers
4. Researchers reach consensus on use of deep brain stimulation to treat Parkinsons
5. AACR to honor leading researchers at breast cancer symposium
6. Medical researchers break down costs to care for heart failure patients at the end of life
7. Researchers Pinpoint Array of Obesity Genes
8. UT Southwestern researchers create experimental vaccine against Alzheimers
9. Wistar researchers discover new class of objects encoded within the genome
10. Blood test could diagnose Alzheimers disease, UT Southwestern researchers find
11. Mayo researchers find biomarkers for personalizing radiation cancer treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ... communities in the greater Dallas, Miami, and Raleigh regions, is organizing an extended ... overcome a rare and deadly chromosome abnormality. , After struggling since birth with ...
(Date:10/13/2017)... ... 13, 2017 , ... The International Association of Eating Disorders ... for the field of eating disorders, announces the opening of early registration for ... Florida at the Omni Resort at ChampionsGate. , The annual iaedp™ ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Many families ... However, many long-term care insurance companies have a waiver for care if the client ... elimination period, when the family pays for care, is often waived, so the benefits ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor ... on sciatica in a new episode of "Success Files," which is an award-winning ... innovation and investigates each subject in-depth with passion and integrity. , Sciatica occurs ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and ... apnea using cutting-edge Oventus O2Vent technology. As many as 18 million Americans ... frequent cessation in breathing. Oral appliances can offer significant relief to about 75 ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... 27, 2017  Commended for their devotion to personalized service, ... as number one in the South Florida Business Journal,s 50 ... 5000 yearly list, the national specialty pharmacy has found its ... will soon be honored by SFBJ as the 2017 ... Set to receive his award in October, Bardisa said ...
(Date:9/25/2017)... 2017  EpiVax, Inc., a leader in the ... today announced the launch of EpiVax Oncology Inc., ... therapeutic cancer vaccines. EpiVax has provided $500,000 in ... enabling technologies to the new precision immunotherapy venture. ... Oncology as Chief Executive Officer. Gad brings over ...
(Date:9/22/2017)... , Sept. 22, 2017 AVACEN Medical (AVACEN) ... is now successfully helping those with the widespread pain ... Fibromyalgia diagnosed Amanda in Essex, England ... washing my hair, experiencing no sleep at all, tremendous ... spasm… I cannot recommend [the AVACEN 100] enough, how ...
Breaking Medicine Technology: