Navigation Links
Researchers advance biosynthesis of potent anti-cancer drug Taxol
Date:9/30/2010

ermediates, taxadiene and taxadien-5alpha-ol.

The researchers partitioned the taxadiene metabolic pathway into two modules: the intracellular supply of substrates, or precursors, that must be present within the E. coli cell before Taxol can be produced (the upstream pathway) and the biosynthetic steps needed to make the first two Taxol intermediates (the downstream pathway).

This modular approach allowed manipulation of the many variables in each pathway to achieve the right balance to optimize production of the two intermediates. It effectively "unlocked" unprecedented production levels of early-stage Taxol intermediates through E. coli.

The team reported producing more than 1 gram of taxadiene per liter of production culture a level that was 1,000 times greater than had previously been reported using E. coli as a host and 15,000 times more than the study's initial production levels prior to balancing the upstream and downstream modular pathways. For the first time, the second Taxol precursor, taxadiene-5alpha-ol, was produced from E. coli.

The researchers caution that significant work is still needed in order to complete the synthesis of a Taxol precursor suitable for commercial production and potentially replace the current plant-based production process with a more efficient operation based upon microbial biosynthesis. Such an approach could also be applied to production of chemicals and fuels microbially derived from renewable resources.

"Though this is only a first step, it is a very promising development and certainly supports this approach and its potential," said Pfeifer.


'/>"/>

Contact: Kim Thurler
kim.thurler@tufts.edu
617-627-3175
Tufts University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... (PRWEB) , ... July 30, 2015 , ... New research ... Click here to read more on the Surviving Mesothelioma website. , ... Hospital in Missouri reviewed more than 12,000 cases of mesothelioma occurring between 1990 and ...
(Date:7/30/2015)... ... ... Bird B Gone, the leader in bird control products for commercial, industrial ... birds from the AC units and ventilation systems on hospital roofs. Bird droppings can ... Nile virus. When these droppings dry, the fine powder can be carried into hospitals ...
(Date:7/30/2015)... ... July 30, 2015 , ... Author Dr. Raul Llanos seeks to ... his new self-help book, “ Consciously Healing our Webs of Health, Wellbeing, Success, and ... “If we take responsibility for ourselves, we can create better realities.” His book illustrates ...
(Date:7/30/2015)... (PRWEB) , ... July 30, 2015 , ... After conducting ... , St. John’s Episcopal Hospital in Far Rockaway, N.Y., has hired Gerard ... , With more than 25 years of healthcare leadership experience, Walsh is an expert ...
(Date:7/30/2015)... ... July 30, 2015 , ... After a three year trial ... implant, more commonly known as the “bionic eye,” researchers have determined the trial to ... tool for patients facing or already affected by complete vision loss as a result ...
Breaking Medicine News(10 mins):Health News:Study Finds Mesothelioma Behaves Differently in Younger People, According to Surviving Mesothelioma 2Health News:Bird B Gone’s New Bird Hazing System Keeps Disease-Carrying Bird Droppings Out of Hospitals 2Health News:New book by Dr. Raul Llanos: ‘The power to change is within’ 2Health News:New book by Dr. Raul Llanos: ‘The power to change is within’ 3Health News:St. John’s Episcopal Hospital Hires New Chief Executive Officer 2Health News:St. John’s Episcopal Hospital Hires New Chief Executive Officer 3Health News:St. John’s Episcopal Hospital Hires New Chief Executive Officer 4Health News:St. John’s Episcopal Hospital Hires New Chief Executive Officer 5Health News:The Vision Enhancing “Bionic Eye” Deemed Safe For Long Term Use After Three Year Clinical Trial 2
... Diagnostics, Holding Promise for Melanoma Patients, NEW ... International Melanoma Congress signals new promise,and hope in treating ... for,those in the advanced stages. Caught early, melanoma is ... melanoma is one of the most incurable,and deadly., ...
... 25 Fire evacuation from the comfort of,your home to ... of a,stadium is difficult for anyone. But it,s harder on ... living. Senior Beth Price was overcome with confusion when ... at 2:00 am on Tuesday morning. "We,didn,t get much notice, ...
... Assist in California Fires Response Effort, TALLAHASSEE, Fla., ... to the California wildfires, the Capital Area Chapter of,the ... the effort. "Whether across the country or around ... is prepared to respond to tragedy and in this,case, ...
... The 2007 Southern California,wildfires have disrupted the lives ... tremendous impact on a person emotionally and physically,including ... have,had to evacuate immediately, leaving behind their homes, ... ever be the same. Aside to,evacuees being affected, ...
... help prevent Alzheimer disease , Alzheimer disease (AD), ... of dementia, is characterized by the formation in the ... indicates that some drugs used to treat high blood ... AD. In a new study, in which they screened ...
... air a way out, experts say , THURSDAY, ... treat emphysema patients shows promise, researchers say. , ... (COPD), is a progressive, irreversible lung disease characterized ... are limited. , The new strategy, called airway ...
Cached Medicine News:Health News:Genes Unlock New Treatments for Deadly Melanoma 2Health News:St. Paul's Senior Homes & Services Welcomes Some of San Diego's Neediest Displaced Seniors 2Health News:St. Paul's Senior Homes & Services Welcomes Some of San Diego's Neediest Displaced Seniors 3Health News:Capital Area Chapter Deploys Volunteers to California 2Health News:California Association of Marriage & Family Therapists Offers Tips on How to Cope With a Traumatic Event 2Health News:JCI table of contents: Oct. 25, 2007 2Health News:JCI table of contents: Oct. 25, 2007 3Health News:JCI table of contents: Oct. 25, 2007 4Health News:JCI table of contents: Oct. 25, 2007 5Health News:JCI table of contents: Oct. 25, 2007 6Health News:JCI table of contents: Oct. 25, 2007 7Health News:JCI table of contents: Oct. 25, 2007 8Health News:JCI table of contents: Oct. 25, 2007 9
(Date:7/30/2015)... 30, 2015 Vermillion, Inc. (VRML), ... disease, announced today it will report its ... market close on Thursday, August 13, 2015, ... webcast at 4:30pm Eastern.Conference Call and Webcast:  ... Eastern/1:30pm Pacific  Domestic: , 888-430-8691International: ...
(Date:7/30/2015)... 2015 What can be expected ... are going to grow at the fastest rates? ... to 2025, assessing data, trends, opportunities and prospects there. ... tables, charts, and graphs. Discover the most lucrative areas ... new study lets you assess forecasted sales at overall ...
(Date:7/30/2015)... 2015  Cleave Biosciences today announced that the ... the company a key patent providing the protection ... This newly issued patent, "Fused pyrimidines ... 9,062,026, allows for claims on the composition of ... inhibitor of p97, a critical enzyme that controls ...
Breaking Medicine Technology:Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 2Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 3Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 4Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 5Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 6
... 2012 Escalon Medical Corp.,s (Nasdaq Market: ESMC) subsidiary, ... successfully completed the outsourced manufacturing of its HbA1c instruments ... sale. Drew has also identified an outsourcing partner for ... available for sale by the summer of 2012.  Drew ...
... Pharmaceuticals, Inc. (Nasdaq: LXRX ) announced today ... and chief executive officer, will present at the RBC Healthcare ... 10:30 a.m. Eastern Time.  Dr. Sands will provide an overview ... A live webcast of the presentation will be available through ...
Cached Medicine Technology:Escalon Announces That the Restructuring of Its IVD Business is Largely Completed 2Escalon Announces That the Restructuring of Its IVD Business is Largely Completed 3Escalon Announces That the Restructuring of Its IVD Business is Largely Completed 4Lexicon Pharmaceuticals to Present at the RBC Healthcare Conference 2
... The Elite II features ... proven University of Glasgow,(UG) algorithm. ... criteria to age, the UG,algorithm ... clinically,significant criteria: gender, age, race, ...
... face provides three contrast levels (high, 9.5 % ... 20/100. This test is designed to detect very ... contact lens evaluation or due to refractive surgery. ... the same contrast and acuity levels as the ...
The CSV-1000ETDRS10% test face presents the standard ETDRS test at a contrast level of 10%. This test is widely used in clinical studies for the evaluation of refractive surgery and contact lenses....
The CSV-1000-1.5CPD is a special test face designed specifically for Food and Drug Administration clinical trials., ,At the recommended test distance of 8 feet, the gratings test one spatial frequenc...
Medicine Products: