Navigation Links
Researchers advance biosynthesis of potent anti-cancer drug Taxol
Date:9/30/2010

MEDFORD/SOMERVILLE, Mass.--Researchers from Tufts University School of Engineering and MIT have reported a new way to biosynthesize important precursors to the potent anti-cancer compound Taxol in an engineered strain of E. coli bacteria.

The findings are significant steps on the way to achieving cost-effective, large-scale production of Taxol and the effort to design new Taxol-like pharmaceuticals.

The work is reported in the October 1, 2010, issue of the journal Science.

Taxol (paclitaxel) and its structural analogs are among the most powerful and commercially successful anticancer drugs, used to treat Kaposi's sarcoma and breast, lung and ovarian tumors.

Taxol was originally derived from the bark of the Pacific yew tree. Its anti-cancer properties were discovered more than 40 years ago.

But Taxol's power comes with an environmental price: Early stage production methods required sacrificing two to four fully grown trees for each patient. Alternative means of production such as using needles rather than bark still rely on slow, laborious plant-based processes. This limits production of Taxol itself and development of new derivatives that might be even more effective.

"This was the basis for our efforts to redirect biosynthesis through a simple, process-friendly bacterium like E. coli," explains Tufts' Blaine Pfeifer, Ph.D., assistant professor of chemical and biological engineering and co-corresponding author on the paper. "We faced a tremendous challenge because of the engineering needed first to 'equip' the E. coli cell to support Taxol biosynthesis and the subsequent protein engineering required to allow the first two steps in the Taxol biosynthesis scheme to be active within this new host."

The complex metabolic sequence that produces Taxol involves at least 17 intermediate steps and is not fully understood. The team's goal was to optimize production of the first two Taxol int
'/>"/>

Contact: Kim Thurler
kim.thurler@tufts.edu
617-627-3175
Tufts University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... 2014 Healthpointe is proud to welcome ... Rodas will be practicing out of Healthpointe’s newest office ... of Healthpointe’s orthopedic team, Dr. Rodas is ... board-certified in occupational medicine. , Among Dr. Rodas’ ... Director of Raytheon, the world-class defense and aerospace company. ...
(Date:8/29/2014)... 2014 A recent article discusses ... a Tokyo clothing store for men with gynecomastia, or male ... or diminishing their problem. Board-certified plastic surgeon Dr. Chasan is ... While many people only associate male breasts with men who ... among men of all ages, often starting in adolescence. Men ...
(Date:8/29/2014)... 29, 2014 (HealthDay News) -- Astronauts may be ... to disrupt human immune systems, a new study suggests. ... long missions to asteroids, the moon and Mars undertaken ... while in space can be dangerous, NASA researchers say. ... in the blood of International Space Station crew members ...
(Date:8/29/2014)... August 29, 2014 Carson Hearing Care ... provide hearing health care tips to local residents on ... section will offer weekly articles from the audiologists at ... including the latest advances in hearing restoration research, new ... The audiologists plan to write a new post on ...
(Date:8/29/2014)... trials based on administering antidepressants for acute and ... trials are needed to determine whether these drugs ... regular basis., Dr. Ian Gilron, a professor and ... of Anesthesiology, and his team of seven researchers ... of antidepressants for pain relief post-surgery would work ...
Breaking Medicine News(10 mins):Health News:Dr. Anthony G. Rodas Joins Healthpointe Team at LAX Office 2Health News:New Bra Created for Men with Gynecomastia, But Will It Work? 2Health News:New Bra Created for Men with Gynecomastia, But Will It Work? 3Health News:Spaceflight Might Weaken Astronauts' Immune Systems 2Health News:Fort Worth Hearing Aid Leader, Carson Hearing Care, Creates Expert Blog to Discuss Important Hearing Healthcare Topics 2Health News:Fort Worth Hearing Aid Leader, Carson Hearing Care, Creates Expert Blog to Discuss Important Hearing Healthcare Topics 3Health News:Antidepressants show potential for postoperative pain 2
... for members and,non-union workers, SACRAMENTO, Calif., Nov. 6 ... more than 97 percent to approve a,groundbreaking new contract ... that are far ahead of the rest of the ... Workers-West (UHW) won the,agreement with their employer after six ...
... Genetics,Inc., (Amex: ILI ), announced today that it ... 13, 2008, at 4:30 pm EST to review the,Company,s ... on,recent corporate developments., To access the live call, ... replay access of the teleconference,will be available on the ...
... a strategic partner in helping,companies optimize their ... for health insurance companies that need to ... improving health risk,assessment participation to engaging members ... approach goes,beyond gift cards or rewards points., ...
... YORK, Nov. 6 HMS Holdings Corp. (Nasdaq:,HMSY) today ... Annual,Global Healthcare Conference, which will be held November 12-14, ... Robert Holster, CEO and Walter Hosp, CFO, will present ... Holdings Corp. (Nasdaq: HMSY ) is the nation,s ...
... the 2008 Excellence in Healthcare Innovation ... ... Sullivan is,pleased to announce that the firm will be presenting Dr. Ralph ... its 2008 North American Healthcare Lifetime,Achievement Award., The Award will be ...
... Improvements - But Overall Failing Grades, WASHINGTON, Nov. ... Cancer Alliance (LCA) marked the start of Lung Cancer ... Lung Cancer", a national,assessment of progress being made in ... improvements, but overall, failing grades continued., (Logo: ...
Cached Medicine News:Health News:United Healthcare Workers Win New Contract with Horizon West 2Health News:United Healthcare Workers Win New Contract with Horizon West 3Health News:Interleukin Genetics Announces Conference Call and Webcast to Discuss Third Quarter 2008 Business Results 2Health News:Health and Wellness Incentives: How Health Insurance Providers Can Motivate and Sustain Member Participation in Wellness Programs 2Health News:Healthcare Pioneer Dr. Ralph Snyderman to Receive Frost & Sullivan's Lifetime Achievement Award 2Health News:Healthcare Pioneer Dr. Ralph Snyderman to Receive Frost & Sullivan's Lifetime Achievement Award 3Health News:Lung Cancer Alliance Releases 4th Annual Report Card on Lung Cancer 2
(Date:8/29/2014)... 29, 2014  Pacific Medical Data Solutions is excited ... design . The main website, along with the site,s ... new services and content relevant to the medical billing ... design, viewers can now better understand how PMDS products ... and create a more visible platform about medical billing ...
(Date:8/29/2014)... Research and Markets  has announced the ... Devices Market 2014-2018" report to their offering. ... cells that connect, support, or surround bones. There are ... ligaments, cartilage, fascia, and other fibrous tissues. Repetitive use, ... age result in wear and tear in these tissues. ...
(Date:8/28/2014)... NEW YORK, Aug. 28, 2014 Reportlinker.com ... available in its catalogue: North America ... 2020 http://www.reportlinker.com/p02343466/North-America-Aesthetic-Lasers-and-Energy-Devices-Market-Outlook-to-2020.html ... Market Outlook to 2020 Summary GlobalData,s ... Devices Market Outlook to 2020", provides key market ...
Breaking Medicine Technology:PMDS Announces New Website 2Global Orthopedic Soft Tissue Repair Devices Market 2014-2018: Key Vendors are ArthroCare, Biomet, DePuy Synthes and Smith & Nephew 2Global Orthopedic Soft Tissue Repair Devices Market 2014-2018: Key Vendors are ArthroCare, Biomet, DePuy Synthes and Smith & Nephew 3North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 2North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 3North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 4North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 5North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 6North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 7North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 8North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 9North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 10North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 11North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 12North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 13North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 14North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 15North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 16
... Hereditary hearing loss is the most common sensory disorder in ... the Institute of Human Genetics at the ... methods, including Roche,s NimbleGen Custom Sequence Capture 385K array to ... X-chromosome of a Spanish family with hereditary hearing loss (1). ...
... Inc. announced today that the first patient has been ... an oligoclonal therapeutic consisting of a mixture of three ... epitopes of the epidermal growth factor receptor (EGFR). ... safety of MM-151 and determine the recommended Phase 2 ...
Cached Medicine Technology:Roche's Sequence Capture Technology Used to Identify SMPX Mutations Underlying Human Hereditary Hearing Loss 2Roche's Sequence Capture Technology Used to Identify SMPX Mutations Underlying Human Hereditary Hearing Loss 3
... tube extension on the proximal ... helps keep connections away from ... enhancing patient mobility and comfort. ... tubes improve tube access for ...
Fome-Cuf® tubes can breathe with the patient to provide a safe, effective, and low pressure seal throughout the ventilatory cycle....
Aire-Cuf® tracheostomy tubes are ideal for short-term to medium-term ventilator support....
Portex® pediatric tracheostomy tubes offer a choice in both form and fit. , ,The anatomical shape of the tube shaft along with the caudal angle of the 15 mm connector provide comfort and security...
Medicine Products: