Navigation Links
Researchers advance biosynthesis of potent anti-cancer drug Taxol
Date:9/30/2010

MEDFORD/SOMERVILLE, Mass.--Researchers from Tufts University School of Engineering and MIT have reported a new way to biosynthesize important precursors to the potent anti-cancer compound Taxol in an engineered strain of E. coli bacteria.

The findings are significant steps on the way to achieving cost-effective, large-scale production of Taxol and the effort to design new Taxol-like pharmaceuticals.

The work is reported in the October 1, 2010, issue of the journal Science.

Taxol (paclitaxel) and its structural analogs are among the most powerful and commercially successful anticancer drugs, used to treat Kaposi's sarcoma and breast, lung and ovarian tumors.

Taxol was originally derived from the bark of the Pacific yew tree. Its anti-cancer properties were discovered more than 40 years ago.

But Taxol's power comes with an environmental price: Early stage production methods required sacrificing two to four fully grown trees for each patient. Alternative means of production such as using needles rather than bark still rely on slow, laborious plant-based processes. This limits production of Taxol itself and development of new derivatives that might be even more effective.

"This was the basis for our efforts to redirect biosynthesis through a simple, process-friendly bacterium like E. coli," explains Tufts' Blaine Pfeifer, Ph.D., assistant professor of chemical and biological engineering and co-corresponding author on the paper. "We faced a tremendous challenge because of the engineering needed first to 'equip' the E. coli cell to support Taxol biosynthesis and the subsequent protein engineering required to allow the first two steps in the Taxol biosynthesis scheme to be active within this new host."

The complex metabolic sequence that produces Taxol involves at least 17 intermediate steps and is not fully understood. The team's goal was to optimize production of the first two Taxol int
'/>"/>

Contact: Kim Thurler
kim.thurler@tufts.edu
617-627-3175
Tufts University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2015)... 06, 2015 The Beryl Institute announces ... of Patient Experience Journal (PXJ), an international, open access, ... understanding and improving patient experience. The second volume of ... conversation globally, helps align the voices engaged and provides ... Published in association with The Beryl Institute, Volume 2, ...
(Date:5/6/2015)... Is Colorado’s legal cannabis industry the victim ... State will mark the 18-month milestone of its historic ... while Colorado’s legal marijuana industry has been successful and ... facing some new challenges. , For example, many marijuana ... in the wake of last month’s “420” cannabis celebrations. ...
(Date:5/6/2015)... Texas (PRWEB) May 06, 2015 vcfo, ... finance, HR, IT and operational support to optimize business ... Consulting CFOs, Jack Lynch and Michael Scheaffer. Both Lynch ... finance and leadership experience. , “We are delighted ... Ellen Wood, vcfo CEO. “Leveraging their background in financial ...
(Date:5/6/2015)... 2015 Anitoa Systems, (“Anitoa”), a Palo ... University of China, has successfully demonstrated a handheld real ... sensor. Anitoa’s handheld qPCR is shown to be ... RNA’s, including hepatitis B, C, and E. Coli. This ... per sample and over 9 orders of magnitude dynamic ...
(Date:5/6/2015)... Locally owned, Greek olive oil producer and importer, Our ... having one the best Extra Virgin Olive Oils in the ... of Greece and known as Laconiko , received the ... Olive Oil, which is defined by the competition as “the ... producer applicants from 25 different countries applying, Laconiko stood out ...
Breaking Medicine News(10 mins):Health News:Patient Experience Journal Releases Spring 2015 Issue 2Health News:As Colorado Faces Regional Shortages, Cannabis CEO Says Marijuana Will Eventually Be Traded like Any Other Commodity 2Health News:As Colorado Faces Regional Shortages, Cannabis CEO Says Marijuana Will Eventually Be Traded like Any Other Commodity 3Health News:vcfo Adds Two Senior Executives to Growing Team 2Health News:Anitoa Systems Demonstrates Compact qPCR using Ultra Low-Light CMOS Bio-Optical Sensor 2Health News:Anitoa Systems Demonstrates Compact qPCR using Ultra Low-Light CMOS Bio-Optical Sensor 3Health News:Greek Extra Virgin Olive Oil, Laconiko Wins Gold at the NYIOOC and Is Featured in Olive Oil Times as One of Greece's Best EVOO's for 2015 2
... BALTIMORE, April 8, 2008 The Johns Hopkins ... agreement with the,University of Patras, the third largest ... student and faculty exchanges., The two schools ... 2008, when representatives from the 43-year-old Greek public,institution ...
... - Sentara Heart Hospital and Sentara Virginia ... Beach General Hospital will use SPY routinely, ... a developer of real-time medical imaging and image guidance,systems ... in Norfolk, Virginia and Sentara Virginia Beach General,Hospital in ...
... PHOENIX, April 8, 2008 NutraCea (OTC Bulletin,Board: NTRZ), ... and technology, announced today that they have accelerated their,plans ... Pelotas,Brazil to meet the demand for rice bran oil ... the plant was operating at less than,one third of ...
... in waking up since coffee, SPARTA, N.J., April 8, ... feeling refreshed and ready to go, you,re not alone. Morning,grogginess ... even driving ability. Fortunately, a unique and ingenious,solution has come ... before,bedtime that will help you to wake up in the ...
... Company acts to ,ensure the integrity of this critical step ... ... April 8, 2008 Navigenics, a,personalized genetic health services company, ... for consumer genomic testing services,and that it will seek broad, ...
... ... Month, PRINCETON, N.J., April 8, 2008 ... regarding the poor state of sexual health in America and urging,Americans to petition ... Evolve tour is designed to address this head on by,inspiring a positive sexual ...
Cached Medicine News:Health News:Johns Hopkins Medical School Sets Research and Teaching Collaboration with University of Patras in Greece 2Health News:Virginia's largest Cardiac Surgery program adopts SPY as standard of care 2Health News:Virginia's largest Cardiac Surgery program adopts SPY as standard of care 3Health News:Virginia's largest Cardiac Surgery program adopts SPY as standard of care 4Health News:Demand for NutraCea Rice Bran Oil Prompts Major Expansion of Irgovel Plant Ahead of Schedule 2Health News:Demand for NutraCea Rice Bran Oil Prompts Major Expansion of Irgovel Plant Ahead of Schedule 3Health News:Tired Mother Invents Pill to Wake You Up On Time 2Health News:Navigenics Proposes Standards for Personal Genomics Services, Coupled With Prospective Outcomes Studies, to Safeguard Consumers 2Health News:Navigenics Proposes Standards for Personal Genomics Services, Coupled With Prospective Outcomes Studies, to Safeguard Consumers 3Health News:Navigenics Proposes Standards for Personal Genomics Services, Coupled With Prospective Outcomes Studies, to Safeguard Consumers 4Health News:Navigenics Proposes Standards for Personal Genomics Services, Coupled With Prospective Outcomes Studies, to Safeguard Consumers 5Health News:Video: Rubber Hits the Road as Trojan(R) Campaigns for Sexual Health in America to Evolve 2Health News:Video: Rubber Hits the Road as Trojan(R) Campaigns for Sexual Health in America to Evolve 3
(Date:5/6/2015)... 2015 CVS Health (NYSE: CVS ) officially announced ... locations that sustained heavy fire damage during protests last week.  ... Baltimore over the past week or so, our hearts ... CVS Health President and CEO Larry Merlo . "Our purpose ... health. There is no better way that we can fulfill that ...
(Date:5/6/2015)... 2015  Rigrodsky & Long, P.A.: , Do you, ... AERI )? , Did you purchase your shares between ... you lose money in your investment in Aerie Pharmaceuticals, Inc.? ... Rigrodsky & Long, P.A. , including former Special Assistant ... complaint has been filed in the United States District Court for ...
(Date:5/6/2015)... Inc., a medical device company focused on the development ... disease, today announced Retired Congressman Norman Dicks ... in the company,s mission to treat vision impairment. ... Representative for Washington,s 6th congressional ... member of the Democratic Party. His district was located ...
Breaking Medicine Technology:CVS Health Announces it Will Rebuild Baltimore CVS/pharmacy Locations 2SHAREHOLDER ALERT: Rigrodsky & Long, P.A. Announces A Securities Fraud Class Action Lawsuit Has Been Filed Against Aerie Pharmaceuticals, Inc. 2SHAREHOLDER ALERT: Rigrodsky & Long, P.A. Announces A Securities Fraud Class Action Lawsuit Has Been Filed Against Aerie Pharmaceuticals, Inc. 3Retired Congressman Norman Dicks Joins LumiThera's Advisory Team 2
... Truphatek has successfully enticed one of the best known professionals in emergency ... , Dan White , formerly of AllMed ... new US subsidiary of Truphatek http://www.truphatek.com/ ... may be reached after this week at 573-240-0002 or by e-mail at ...
... Oct. 6 AMICAS, Inc. (Nasdaq: AMCS ), ... launch AMICAS RIS(TM) Version 5.5 at RBMA,s 2009 Fall ... 13. AMICAS will be in booth #203. , (Logo: ... RIS Version 5.5 introduces sophisticated workflow tools to help ...
Cached Medicine Technology:New Places and People - Truphatek opens USA subsidiary 2New Places and People - Truphatek opens USA subsidiary 3AMICAS Launches Major New Version of Radiology Information System at RBMA 2009 2AMICAS Launches Major New Version of Radiology Information System at RBMA 2009 3
Cementless hip system...
... knee system continues the "Consensus Concept" ... engineering with the diversified experience of ... is an affordable knee system that ... are designed to provide both joint ...
... System offers a femoral option and tibial ... action that engages at 60 degrees of ... roll-back motion and allow for 130 degrees ... conjunction with the femur is designed to ...
... The P.F.C. SIGMA Total Knee System is ... solutions for a variety of clinical indications. ... Knee System introduced in 1984, P.F.C. SIGMA ... clinical proof.,P.F.C. SIGMA is designed to address ...
Medicine Products: