Navigation Links
Researchers Use Gene to End High Blood Sugar in Mice
Date:3/18/2009

Whether method might someday help people awaits further study

WEDNESDAY, March 18 (HealthDay News) -- Delivering a gene called neurogenin3 into the livers of diabetic mice activates adult stem cells that promote steady insulin production, say researchers at the Baylor College of Medicine in Houston.

The mice had type 1 diabetes. Within a week after the gene was delivered using a disarmed virus, the researchers said, the rodents' blood sugar levels returned to normal and remained that way for the rest of their lives.

The gene triggers a two-step response. First, neurogenin3 goes into the mature liver cells and causes them to make small quantities of insulin, enough to reduce blood sugar levels to normal.

"This is a transient effect. Liver cells lose the capacity to make insulin after about six weeks," Dr. Vijay Yechoor, assistant professor of medicine-endocrinology at Baylor and the study's first author, said in a news release from the college.

Other cells that make larger amounts of insulin show up later. These cluster around the portal veins, which carry blood from the intestines and abdominal organs to the liver. These new cells, which look similar to pancreatic islet cells that normally make insulin, come from a small population of adult stem cells usually found near the portal vein, the authors said.

These stem cells normally act as reserves in case of liver injury. When the liver is damaged, the stem cells form mature liver cells or bile duct cells. But neurogenin3 changes their programming so that they become insulin-producing beta cells in the liver, the researchers said.

The study appears in the March issue of Developmental Cell.

Though the finding is important, much more research is needed before similar results might be seen in humans, Yechoor and his colleagues said.

More information

The U.S. National Diabetes Information Clearinghouse has more about diabetes.



-- Robert Preidt



SOURCE: Baylor College of Medicine, news release, March 16, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers Use Gene to End High Blood Sugar in Mice
(Date:3/29/2017)... (PRWEB) , ... March 30, 2017 , ... Sports Brand ... brace, which retails normally at $29.97; for the remaining days of March, the ... also been reduced to a special price of just $10 (regular retail price $19.97). ...
(Date:3/29/2017)... ... March 29, 2017 , ... AngioGenesis ... Walgreens store in Mississippi. AngioGenesis Labs, makers of HeartBoost, BrainBest and BeautyBest, achieved ... states. Ingredients in HeartBoost, an over the counter heart healthy drink, can reduce ...
(Date:3/29/2017)... ... March 29, 2017 , ... ... provides insight into the challenges employers face in trying to balance both short-term ... employee benefits programs? Adding to the growing complexity, companies are finding that ...
(Date:3/29/2017)... ... March 29, 2017 , ... Dr. Angela Cotey, a noted general dentist in ... pediatric patients, with or without a referral. Dr. Cotey knows that interceptive orthodontics ... and experience. When patients receive early treatment, they may achieve straight teeth with less ...
(Date:3/29/2017)... ... March 29, 2017 , ... How big ... outpatient facilities, and who are the most active developers? , In the ... Healthcare Real Estate Insights (HREI) found that outpatient medical real estate development projects ...
Breaking Medicine News(10 mins):
(Date:3/30/2017)... March 30, 2017 Revenue Prospects by Product ... and COPD) and Geography Respiratory Inhalers - our new ... the Respiratory Inhalers market heading? If you are involved in this ... report shows you the potential revenues streams to 2027, assessing data, ... ...
(Date:3/29/2017)... , Mar. 29, 2017 Research ... Neuromonitoring (IONM) Market Size & Forecast By Type (Insource IONM, ... 2025" report to their offering. ... The global Intraoperative Neuromonitoring ... 2025. The intraoperative neuromonitoring market is anticipated to witness significant ...
(Date:3/29/2017)... 2017 Research and Markets has announced the ... report to their offering. ... The global energy-based aesthetic devices market to grow at ... The report, Global Energy-Based Aesthetic Devices Market 2017-2021, has been prepared ... The report covers the market landscape and its growth prospects over ...
Breaking Medicine Technology: