Navigation Links
Researchers Turn Stem Cells Into Intestinal Tissue in Lab
Date:12/13/2010

MONDAY, Dec. 13 (HealthDay News) --Researchers say they've turned human stem cells into functioning human intestinal tissue in a laboratory setting.

The study team described its accomplishment as a "significant step" forward in efforts to better understand the function and development of the human intestine. They also expressed hope that the innovation will spur the development of new strategies to combat intestinal diseases, while opening up new avenues for the generation of transplantation tissue.

"The hope is that our ability to turn stem cells into intestinal tissue will eventually be therapeutically beneficial for people with diseases such as necrotizing enterocolitis, inflammatory bowel disease and short bowel syndromes," explained study senior author James Wells, a researcher in the division of developmental biology at Cincinnati Children's Hospital Medical Center, in a hospital news release.

Wells and his colleagues report their findings in the Dec. 12 online issue of Nature.

The authors used two types of so-called "pluripotent" stem cells -- cells that have the chameleon-like ability to differentiate into any one of about 200 distinct cell types.

Human embryonic stem cells, which are known to have such transformative abilities, were one type. For the other, the researchers looked to "induced" stem cells -- cells harvested from patients and reprogrammed in the lab to function as pluripotent stem cells.

Though less well-tested than embryonic stem cells, induced cells theoretically have the advantage of minimizing the risk for cell rejection when replanted back into the host patient.

In a petri dish, both types of stem cells were subject to a series of chemical- and protein-triggered processes that caused them to develop into the building blocks of various organ components, such as the lining of the esophagus, stomach and intestines.

Over four weeks, Wells and his associates used this approach to form three-dimensional fetal-like intestinal tissue involving all the major players in intestinal cellular development.

This incipient tissue continued to develop, ultimately performing the functions of normal intestinal tissue, the researchers said.

The research was funded by the U.S. National Institutes of Health and the Juvenile Diabetes Research Foundation.

More information

For more on stem cells, visit the U.S. National Institutes of Health.

--Alan Mozes

SOURCE: Cincinnati Childrens Hospital Medical Center, news release, Dec. 12, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers Turn Stem Cells Into Intestinal Tissue in Lab
(Date:7/20/2017)... ... July 20, 2017 , ... ... further expand its existing adherence automation lines. The ATP® Mini and InspectRx® ... technology of TCG’s standard products, but at a size and price point that ...
(Date:7/20/2017)... ... July 20, 2017 , ... ... since 2014, top travel insurance solution company VisitorsCoverage Inc. has launched TMQuotes, a ... major international travel insurance products online, under their own brand. The online marketplace ...
(Date:7/20/2017)... ... 2017 , ... A local summer theatre camp is celebrating ... support fine arts programs in Chester County’s Elementary Schools. In late June, students ... , More than 850 people attended the two performances, an increase from ...
(Date:7/20/2017)... (PRWEB) , ... July 19, 2017 , ... Med Tech ... the Minnesota based Health IT business unit of Constellation Inc., a move that will ... established base of operations in St. Louis, the acquisition is expected to help ...
(Date:7/20/2017)... ... July 19, 2017 , ... A July 5th ... weight loss surgery patients who had received a body contouring procedure reported experiencing a ... clinic Beverly Hills Physicians (BHP), which provides both types of procedures, notes that this ...
Breaking Medicine News(10 mins):
(Date:7/13/2017)... July 13, 2017  Centurion Medical Products, a leader in medical ... ® fecal impaction removal device for hospice patient care. ... Centurion Medical Products ... Patient pain management and emotional comfort are ... help alleviate patient pain while preventing unneeded emergency department admission due ...
(Date:7/12/2017)... Lilly and Company (NYSE: LLY ) has entered ... patent litigation in the U.S. District Court for the Eastern ... ® (tadalafil) unit dose patent. This patent was previously ... the agreement, Cialis exclusivity is now expected to end at ... dose patent for Cialis is valid and infringed by companies ...
(Date:7/11/2017)... July 11, 2017  Sysmex America, Inc., a ... testing equipment as well as middleware information systems ... to make quality assurance easier and more risk ... well known for the innovation that it delivers ... elevates quality assurance processes to a new level ...
Breaking Medicine Technology: