Navigation Links
Researchers Turn Stem Cells Into Intestinal Tissue in Lab
Date:12/13/2010

MONDAY, Dec. 13 (HealthDay News) --Researchers say they've turned human stem cells into functioning human intestinal tissue in a laboratory setting.

The study team described its accomplishment as a "significant step" forward in efforts to better understand the function and development of the human intestine. They also expressed hope that the innovation will spur the development of new strategies to combat intestinal diseases, while opening up new avenues for the generation of transplantation tissue.

"The hope is that our ability to turn stem cells into intestinal tissue will eventually be therapeutically beneficial for people with diseases such as necrotizing enterocolitis, inflammatory bowel disease and short bowel syndromes," explained study senior author James Wells, a researcher in the division of developmental biology at Cincinnati Children's Hospital Medical Center, in a hospital news release.

Wells and his colleagues report their findings in the Dec. 12 online issue of Nature.

The authors used two types of so-called "pluripotent" stem cells -- cells that have the chameleon-like ability to differentiate into any one of about 200 distinct cell types.

Human embryonic stem cells, which are known to have such transformative abilities, were one type. For the other, the researchers looked to "induced" stem cells -- cells harvested from patients and reprogrammed in the lab to function as pluripotent stem cells.

Though less well-tested than embryonic stem cells, induced cells theoretically have the advantage of minimizing the risk for cell rejection when replanted back into the host patient.

In a petri dish, both types of stem cells were subject to a series of chemical- and protein-triggered processes that caused them to develop into the building blocks of various organ components, such as the lining of the esophagus, stomach and intestines.

Over four weeks, Wells and his associates used this approach to form three-dimensional fetal-like intestinal tissue involving all the major players in intestinal cellular development.

This incipient tissue continued to develop, ultimately performing the functions of normal intestinal tissue, the researchers said.

The research was funded by the U.S. National Institutes of Health and the Juvenile Diabetes Research Foundation.

More information

For more on stem cells, visit the U.S. National Institutes of Health.

--Alan Mozes

SOURCE: Cincinnati Childrens Hospital Medical Center, news release, Dec. 12, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers Turn Stem Cells Into Intestinal Tissue in Lab
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and ... that call for a minimum wage raise to $12 an hour by 2020 and then ... will restore the lost value of the minimum wage, assure the wage floor does not ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine ... Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor ... Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With this ...
(Date:6/24/2016)... Nevada (PRWEB) , ... June 24, 2016 , ... ... Vegas client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations ... in Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a ...
(Date:6/24/2016)... ... 2016 , ... National recruitment firm Slone Partners is pleased to ... genomics experience, as Vice President of North American Capital Sales at HTG Molecular ... the sales team in the commercialization of the HTG EdgeSeq system and associated reagents ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... pluripotent stem (iPS) cells and other difficult to transfect cells, announces its launch ... PluriQ™ G9™ Gene Editing System is a complete system for culturing ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- In a startling report released today, National Safety Council ... comprehensive, proven plan to eliminate prescription opioid overdoses. Prescription ... are tackling the worst drug crisis in recorded U.S. history, assigned ... Kentucky , New Mexico , ... 28 failing states, three – Michigan , ...
(Date:6/23/2016)... June 23, 2016 Capricor ... ), a biotechnology company focused on the discovery, ... that patient enrollment in its ongoing randomized HOPE-Duchenne ... exceeded 50% of its 24-patient target. Capricor expects ... third quarter of 2016, and to report top ...
(Date:6/23/2016)... , June 23, 2016 , ... Thursday, July 7, 2016 , , , , LOCATION: , ... , , , , EXPERT PANELISTS:  , , , Frost ... Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh ... The global pharmaceutical industry is witnessing an exceptional era. Several ...
Breaking Medicine Technology: